Saghaf ian, M., Esmaeilzadeh, S., Razi Jalali, M. (2009). A pathological and biochemical survey on renal lesion due to Buthotus saulcyi scorpion venom injection in rats. , 22(3), 2-9.
M Saghaf ian; S Esmaeilzadeh; M Razi Jalali. "A pathological and biochemical survey on renal lesion due to Buthotus saulcyi scorpion venom injection in rats". , 22, 3, 2009, 2-9.
Saghaf ian, M., Esmaeilzadeh, S., Razi Jalali, M. (2009). 'A pathological and biochemical survey on renal lesion due to Buthotus saulcyi scorpion venom injection in rats', , 22(3), pp. 2-9.
Saghaf ian, M., Esmaeilzadeh, S., Razi Jalali, M. A pathological and biochemical survey on renal lesion due to Buthotus saulcyi scorpion venom injection in rats. , 2009; 22(3): 2-9.

A pathological and biochemical survey on renal lesion due to Buthotus saulcyi scorpion venom injection in rats

تحقیقات دامپزشکی و فرآورده‌های بیولوژیک
Editorial, Volume 22, Issue 3, September 2009, Pages 2-9    PDF (1.82 M)
Authors
M Saghaf ian* 1; S Esmaeilzadeh2; M Razi Jalali3
1Veterinary Graduated of Veterinary Faculty of Shahid Chamran University
2DVM, DVsc (Pathol) Associated Professor, Department of Pathobiology, School of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, Iran
3DVM, DVsc (Clin. Pathol) Associated Professor, Department of Clinical Sciences, School of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, Iran
Abstract
 Buthotus saulcyi is one of the six most important scorpion species in Khuzestan province, which its venom causes probable general effects on its victims. Due to insufficient knowledge about mechanism of the venom functions and its target organs and highly dependence of health to normal function of kidney, this survey has been accomplished. In present study, 75 male Wistar rats were selected and divided randomly to five groups (A-E). Then 18, 24, 30 and 36 µgr/Rat of the venom and 1ml normal saline was injected subcutaneously to groups A-E, respectively. After 3, 6, 12 and 36 hours of envenomation, blood sampling, euthanasia and necropsy were performed. Histopathological study was performed on renal tissue samples and verification of BUN, uric acid, creatinine, Na and K of blood samples, were also measured. Results showed no significant correlation between injection of examined doses of the venom and renal lesions but significant modification in some blood parameters depended to dose and time were seen(P<0.05). Therefore it can presume that although examined doses of the venom can affect renal index parameters of blood but these amounts of venom have not much ability to induce renal lesions.
References

1- حبیبی، ط، (1371)، جانور شناسی عمومی، جلد سوم، انتشارات دانشگاه تهران، تهران، صفحات 230-280##

2- فرزان پی، ر، (1371)، عقرب شناخت، مرکز انتشارات نشر دانشگاهی، تهران، صفحات 147 و 191-190##

3- کمالی، ک، (1379)، عقرب‌های خوزستان. مجله پژوهش و سازندگی. سال دهم، جلد سوم، صفحات 57-60 ##

4- نیاورانی، ا، ر، (1375)،  فیزیولوژی پزشکی گایتون. تالیف: گایتون، آرتور سی و هال، جان ئی. جلد اول، چاپ اول، نشر طیب، تهران، صفحات 323-326 و 325-353##

5- Arthur, J. E., Lucke, V. M., Newby, T. J. and Bourne, F. J. (1984), An Immunohistological study of feline glomerulonephritis using the peroxidase – antiperoxidase method. Research in Veterinary Science, 37: 12-17.##

6- Bessalem, S., Hammoudi – Triki, D. and Laraba- Djebari, F. (2003), Effect of immunotherapy and metabolic histopathological modification after experimental scorpion envenomation. Bulletin of Exotic Pathology Society, 96 (2): 110-114.##

7- Burtis, C. And Ashwood, E. (2000), Tietz fundamentals of clinical chemistry. 5 th edition, W. B. Saunders Company, Philadelphia, pp: 682-723.##

8-Confer A.W. and Panciera, R.J. (2001), Urinary system. In: McGavin, M.D., Carlton, W.W. and Zachary, J.E. (Eds). Thomson's special veterinary pathology. 3rd edition. Mosby Inc., London, pp: 235-277. ##

9- De Roodth, A. R., Gimeno, E., Ortiansky, E., Varni, L., Dolab, J.A., Segre, L., Litwin, S. and Vidal, J. C. (2001), A study on experimental envenomation in mice with the venom of Tityus trivitattus kraepelin captured in Argentina. Journal of National Medicine Association, 10 (2): 99-109.##

10- De Sousa Alves, R., Do Naseimento, N. R., Barbosa, P. S., Kerntopf, M. R., Lessa, L. M., De Sousa, C. M., Martins, R. D., Sousa, D. F., De Queiroz, M. G., Toyama, M. H., Fonteles, M. C., Martins, A. M., Monteiro, H. S. (2005), Renal effects and vascular reactivity induce by tityus serrulatus venom. International Society of Toxicology, 46 (3): 271-276.##

11- Dibartola, S. P. and Rutgers, H. C. (1994) Disease of kidney. In: Sherding, R. G. (Ed). The Cat Disease and Clinical Management. Vol. 2, 2nd edition, W. B. Saunders Company, London, pp: 1711-1767.##

12- Dosreis, H. A., Costa, R. S., Coimbra, T. M. and Teixeira, V. P. (1998) Acute renal failure in experimental envenomation with Africanized bee venom. Renal Failure, 20 (1) pp: 39-51.##

13- Gajalakshmi, B. S., Ramaswamy, N., Tniagarajan, C. and Yahya, G. M. (1979) Certain observations in electrocardiogram and enzyme variation in dogs following scorpion venom injection. Indian Journal of Physiology and Pharmacology, 22: 397-400##

14- Kumar, V., Contran, R. S. and Robins, S. L. (1992) Basic Pathology. 5th edition, W. B. Saunders Company, London: pp: 21-34, 127-130, 440-445.##

15- Malhotra, K. K., Mirdehghan, C. M. and Tandon, H.D. (1978)Acute renal failure following scorpion sting. American Journal of Tropical Medicine and Hygiene, 27 (3): 623-626.##

16- Maxie, M. G. (1993) The urinary system. In: Jubb, K. V. F., Kennedy, P. C. and Palmer, N. (Eds). Pathology of Domestic Animals. Vol. 2, 4th edition, Academic Press, Inc. California, pp: 185-395.##

17- Meki, A. R., El- Deen, Z. M. El Deen, H. M. (2002)Myocardial injury in scorpion envenomed children: Significance of assessment of serum troponin I and interleukin - 8. Neurology and Endocrinology, 23 (2): 133-140.##

18- Omran, M. A. And Abdel – Rahmans, M. S. (1992) Effects of scorpion Leiurus quinquestriatus venom on clinical chemistry parameters of the rat. Toxicology letters, 61 (1): 90-109.##

19- Rahmy, T. M. (1998) Action of cobra venom on the renal cortical tissue: Electormicroscopic studies. International Society of Toxicology, 36: 657-64.##

20- Slauson, D. O. and Cooper, B. J. (2002) Mechanisms of Disease. A Text Book of Comparative General Pathology. 3rd Ed., Mosby, London, pp: 215-320, 279-281##

21- Slauson, D. O. and Lewis R. M. (1979) Comparative pathology of glomerulonephritis in animals. Veterinary Pathology, 16: 135-164.##

Statistics
Article View: 1,161
PDF Download: 1,271


counter
Journal management system. designed by sinaweb