Nemati, M. (2021). Effect of nitroglycerin slow release drug on performance, blood and hormonal parameters of broiler chicks under ascites induction conditions. , 33(129), 61-74. doi: 10.22092/asj.2019.127201.1958
Mohammad Hossein Nemati. "Effect of nitroglycerin slow release drug on performance, blood and hormonal parameters of broiler chicks under ascites induction conditions". , 33, 129, 2021, 61-74. doi: 10.22092/asj.2019.127201.1958
Nemati, M. (2021). 'Effect of nitroglycerin slow release drug on performance, blood and hormonal parameters of broiler chicks under ascites induction conditions', , 33(129), pp. 61-74. doi: 10.22092/asj.2019.127201.1958
Nemati, M. Effect of nitroglycerin slow release drug on performance, blood and hormonal parameters of broiler chicks under ascites induction conditions. , 2021; 33(129): 61-74. doi: 10.22092/asj.2019.127201.1958

Effect of nitroglycerin slow release drug on performance, blood and hormonal parameters of broiler chicks under ascites induction conditions

علوم دامی
Volume 33, Issue 129, March 2021, Pages 61-74    PDF (1.73 M)
Document Type: Research Paper
DOI: 10.22092/asj.2019.127201.1958
Author
Mohammad Hossein Nemati*
Scientific member of agriculture and natural resourse research center of Zanjan
Abstract
This experiment was conducted to evaluate the effect of addition of a nitroglycerin (NG) slow release drug on performance, blood and hormonal parameters of broiler chicks under ascites induction conditions. A total of 500 broiler chicks at 7 days of age were used in a completely randomized design with 5 treatments, 5 replicates and 20 chicks per each replication. The experimental treatments included: 1) positive control group (without induction of ascites and without addition of NG); 2) negative control group (induction of ascites without adding NG, treatments 3, 4 and 5, including induction of ascites with 5, 10 and 20 mg/kg NG in diet, respectively. In order to induce cold stress, the temperature was fixed at 15oC from 15 until 42 day of age. The results showed that the feed intake and body weight were not affected by experimental treatments in the growth and finisher period, but the use of nitroglycerin (20 mg / kg) resulted in a significant improvement in the feed conversion ratio (FCR) during the finisher and the whole period. Efficiency of energy and protein consumption as well as production index significantly improved with consumption of 20 mg NG compared to negative control group, which was comparable to that of control group. The concentration of blood glucose was significantly increased as a result of stress. The levels of T3 and T3 / T4 ratios increased by stress and decreased by using NG.
Keywords
cold stress; broilers; biochemical parameters; performance; nitroglycerin
References
  1. روشنایی، ی.، امینی، ا. کربلائی محمد میگونی، ع. 1398. داروهای ژنریک ایران. ویرایش چهارم. انتشارات روشن کتاب.
  2. (2014). Ross 308. Broiler Performance Objective. Retrieved from www.aviagen.com. Accessed on May 21.
  3. Blahova, J., Dobsikova, R., Strakova, E. and Sucha, P. (2007). Effect of low environmental temperature on performance and blood system in broiler chickens (Gallus domesticus) Acta veterinaria Brno. 76: S17–S23.
  4. Collin,, Buyse, J., AS P.V., Darras, V.M., Malheiros, R.D., Moraes, V.M.B., Reyns, G.E., Taouis, M. and Decuypere, E. (2003). Cold-induced enhancement of avian uncoupling protein expression, heat production, and triiodothyronine concentrations in broiler chicks. General and Comparative. Endocrinology. 130(1): 70–77.
  5. Daneshyar, M., Kermanshahi, H. and Golian, A. (2009). Changes of biochemical parameters and enzyme activities in broiler chickens with cold-induced ascites. Poultry Science. 88: 106-110.
  6. Eid, Y.Z., Ohtsuka, A. and Hayashi, K. (2003). Tea polyphenols reduce glucocorticoid-induced growth inhibition and oxidative stress in broiler chickens. British Poultry Science, 44: 127–132.
  7. Erf, G.F. (2004). Cell-mediated immunity in poultry. Poultry Science. 83: 580–590.
  8. Forman, M.F., and Wideman, R.F. (2001). Furosemide does not facilitate pulmonary vasodilation in broilers during chronic or acute unilateral pulmonary arterial occlusion. Poultry Science. 80: 937-943.
  9. Hangalapura, B.N. (2006). Cold stress and immunity: Do chickens adapt to cold by trading-off immunity for thermoregulation?. ISBN: 90-8504-358-1.
  10. Hangalapura, B.N., Nieuwland, M.G.B., De Vires Reilingh, G., Heetkamp, M.J.W., Van den Brand, H., Kemp, B. and Parmentier, H.K. (2003). Effect of cold stress on immune responses and body weight of chickens lines divergently selected for antibody responses to sheep red blood cells. Poultry Science. 82: 1692-1700.
  11. Honda, K., Kamisoyama, H., Saito, N., Kurose, Y., Sugahara, K. and Hasegawa, S. (2007). Central administration of glucagon suppresses food intake in chicks. Neuroscience Letters. 416: 198–201.

12.  Huang, P.L., Huang, Z., Mashimo, H., Bloch, K.D., Moskowitz, M.A., Bevan, J.A.and Fishman, M.C. (1995). Hypertension in mice lacking the gene for endothelial nitric oxide synthase. Nature. 377: 239-242.

  1. Ipek, A. and Sahan, U. (2006). Effects of cold stress on broiler performance and ascites susceptibility. Asian Australasian Journal of Animal Science. 19: 734-738.
  2. Khajali, F & Wideman RF. (2010). Dietary arginine: metabolic, environmental, immunological and physiological interrelationships. World's Poultry Science Journal, 66: 751-766.
  3. Khajali F, Moghaddam MH & Hassanpour H. (2014). An L-Arginine supplement improves broiler hypertensive response and gut function in broiler chickens reared at high altitude. International Journal of Biometeorology. 58: 1175-1179.
  4. Mckee, J.C., Harrison, P.C., and Riskowski, G.L. (1997). Effects of supplemental ascorbic acid on the energy conversion of broiler chicks during heat stress and feed withdrawal. Poultry Science. 76: 1278–1286.
  5. Mendes, A.A., Watkins, S.E., England, J.A., Saleh, E.A., Waldroup, A.L. and Waldroupp, W. (1997). Influence of dietary lysine levels and arginine:lysine ratios on performance of broilers exposed to heat or cold stress during the period of three to six weeks of age. Poultry Science. 76: 472–481.
  6. Moreno, S.M. and Hernandez, A. (2003). Nitric oxide synthase expression in the endothelium of pulmonary arterioles in normal and pulmonary hypertensive chickens subjected to chronic hypobaric hypoxia. Avian Diseases. 47: 1291-1297.
  7. Nichelmann, M. and Tzschentke, B. (2002). Ontogeny of thermoregulation in precocial birds. Comparative Biochemistry and Physiology. Part A, Molecular and Integrative Physiology 131: 751–763.
  8. Ocampo, L., Cortez, U., Sumano, H. and Avila, E. (1998). Use of low dose of Clenbuterol to reduce incidence of ascites syndrome in broilers. Poultry Science. 77: 1297-1299.
  9. Ognik K. and Sembratowicz I. 2012. Stress as a factor modifying the metabolism in poultry. A Rewiew. Annales UMCS, Zootechnica 30(2):34-43.
  10. Ozdemir, H.S., Aksulu, H.E., Karatas, F., Ustundag, B. and Bingo, I. (2000). Long-term lisinopril dehydrate application decrease plasma noradrenaline but not adrenaline levels in chickens. Physiological Research. 64: 183-188.
  11. Prasad, K., Chang, J.B., Oksen, E.R. and Sumpio, B.E. (2000). Textbook of Angiology. 1 st Edition. Chapter4: Blood Pressure and Its Control Mechanism. pp: 46-54. Springer, New York.
  12. Puvadolpirod, S. and Thaxton, J.P. (2000). Model of physiological stress in chickens 4. digestion and metabolism. Poultry Science. 79: 383–390.
  13. Ruiz-Feria, C.A. (2009). Concurrent supplementation of arginine, vitamin E, and vitamin C improve cardiopulmonary performance in broilers chickens. Poultry Science. 88: 526-535.
  14. Sahin, N., Onderci, M. and Sahin, K. (2002). Effects of dietary chromium and zinc on egg production, egg quality and some blood metabolites of laying hens reared under low ambient temperature. Biological Trace Element Research. 85: 47–58.
  15. Saki A, Haghighat M & Khajali F. (2013). Supplemental arginine administered in ovo or in the feed reduces the susceptibility of broilers to pulmonary hypertension syndrome. British Poultry Science. 54: 575-580.
  16. SAS (2002-2003). SAS/STAT Software: change and enhancement through release 9.1. SAS Inst. Inc., Cary, NC, USA.
  17. Shahir, M. H., Dilmagani, S. and Tzschentke, B. (2012). Early-age cold conditioning of broilers: effects of timing and temperature. British Poultry Science. 53:538-544.
  18. Sharifi MR., Khajali, F., Hassanpour, H., Pour-Reza, J., and Pirany, N. (2015). Supplemental L-arginine Modulates Developmental Pulmonary Hypertension in Broiler chickens Fed Reduced-Protein Diets and Reared at High Altitude. Poultry Science Journal. 3 (1): 47-58
  19. Tan, X., Hu, S.H. and Wang, X.L. (2007). Possible role of nitric oxide in the pathogenesis of pulmonary hypertension in broilers: a synopsis. Avian Pathology. 36: 261-267.
  20. Virden, W.S. and Kidd, M.T. (2009). Physiological stress in broiler: Ramifications on nutrient digestibility and responses. Journal of Applied Poultry Research. 18: 338-347.
  21. Wideman, R.F., Chapman, M.E., Hamal, K.R., Bowen, O.T., Lorenzoni, A.G., Erf, G.F. and Anthony, N.B. (2007). An inadequate pulmonary vascular capacity and susceptibility to pulmonary arterial hypertension in broilers. Poultry Science. 86: 984-998.
  22. Wideman, R.F., Ismail, M., Kirby, Y.K., Bottje, W.G., Moore, R.W. and Vardeman, R.C. (1995). Furosemide reduces the incidence of pulmonary hypertension syndrome (ascites) in broiler exposed to cool environmental temperatures. Poultry Science. 74: 314-322.
  23. Wideman, R.F., Rhoads, D.D., Erf, G.F. and Anthony, N.B. (2013). Pulmonary arterial hypertension (ascites syndrome) in broilers: A review. Poultry Science. 92: 64-83.
  24. Wu, D.J., Lin, J.A. and Lin, C.S. (2007). Reduction of dilated cardiomyopathy of broiler chickens model by pharmacological treatments- pathological aspects. Taiwan Veterinary Journal. 33: 6-13.
  25. Yahav, S. (1999). The effect of constant and diurnal cyclic temperatures on performance and blood system of young turkeys. Journal of Thermal Biology. 24: 71-78.
  26. Yahav, S. (2002). Limitations in energy intake affect the ability of young turkeys to cope with low ambient temperatures. Journal of Thermal Biology. 27: 103-108.
  27. Yardimci, M., Sengor, E., Sahin, E.H., Bayram, I. and Cetingul, I.S. (2006). The Influence of Cold Conditioning on the Performance of the Broiler Chicken.Turkish Journal of Veterinary and Animal Sciences. 30: 583-588.
  28. Yersin, A.G., Huff, W.E., Kubena, L.F., Elissalde, M.A., Harvey, R.B., Witzel, D.A. and Giroir, L.E. (1992). Changes in hematological, blood gas and serum biochemical variables in broilers during exposure to stimulated high altitude. Avian Disease. 36: 189–197.
Statistics
Article View: 378
PDF Download: 403


counter
Journal management system. designed by sinaweb