
مروری بر ایزوله های اشرشیاکلی مقاوم به کولیستین در خاورمیانه: مکانیسم ها، اپیدمیولوژی و انتشار از منشأهای مختلف در انسان، حیوان، غذا و خاک | ||
Archives of Razi Institute | ||
Article 3, Volume 79, Issue 1, January and February 0, Pages 13-27 PDF (649.22 K) | ||
Document Type: مقاله مروری | ||
DOI: 10.32592/ARI.2024.79.1.13 | ||
Abstract | ||
اشرشیاکلی فلور نرمال روده است که می تواند باعث بیماری های مختلفی مانندبیماری های روده، مجاری ادراری، سیستیت و عفونت های سیستمیک در انسان و حیوان شود. افزایش نگران کننده در شیوع پروفیل های تولید کننده بتالاکتاماز با طیف گسترده و ایزوله های اشریشیاکلی تولید کننده کارباپنماز یک مشکل جدی در سراسر جهان است. کولیستین به عنوان یک آنتی بیوتیک آخرین راه حل برای درمان عفونت های باکتریایی گرم منفی شناخته شده است. استفاده نامناسب از کولیستین و سایر کلاس های آنتی بیوتیک در ترکیب با کنترل ضعیف عفونت به ویژه در کشورهای در حال توسعه می تواند منجر به عوارض جدی در محیط های بهداشت عمومی شود. افزایش جهانی مقاومت به کولیستین در بسیاری از نقاط جهان و همچنین در منطقه خاورمیانه گزارش شده است. کولیستین برای درمان عفونت های ناشی از باکتری های گرم منفی بسیار مقاوم به دارو استفاده می شود. دادههای اپیدمیولوژیک قابل اعتماد از ایزولههای اشرشیاکلی مقاوم به کولیستین بسیار کمیاب است، با این حال، اطلاعات مربوط به اشرشیاکلی مقاوم به کولیستین از آسیا، بزرگترین، پرجمعیتترین و متنوعترین قاره جهان، به طور کلی در مقایسه با اروپا و ایالات متحده آمریکا محدود است. دادههای این مقاله مروری از مقالات مربوطه در ارتباط با جدایه های اشریشیا کلی مقاوم به کولیستین از نمونه های انسان، حیوانات و حیوانات مولد غذا جمعآوری شد. در خاورمیانه، ایزولههای اشریشیا کلی مقاوم به کولیستین از ترکیه، مصر، عربستان سعودی، الجزایر، ایران، عراق، بحرین، قطر، عمان، کویت، اسرائیل و لبنان بین سالهای 2010 تا 2022 گزارش شده است. دادهها نشان داد که ژنهای mcr در مقایسه با جهشهای ژنهای pmrAsB، phoQ و mgrB، شایعترین ژنهای مرتبط با مقاومت به کولیستین در ایزولههای اشریشیا کلی هستند | ||
Keywords | ||
مقاومت به کولیستین; اشریشیا کلی; مکانیسم مولکولی; کشورهای خاورمیانه | ||
Supplementary Files
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References | ||
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