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ارزیابی بالینی مصرف آب انار بر بهبود فشار خون، عملکرد عروق و فاکتورهای لیپیدی در افراد با فشار خون بالا | ||
| تحقیقات گیاهان دارویی و معطر ایران | ||
| مقاله 5، دوره 31، شماره 3 - شماره پیاپی 71، مرداد 1394، صفحه 418-427 اصل مقاله (237.67 K) | ||
| نوع مقاله: مقاله پژوهشی | ||
| شناسه دیجیتال (DOI): 10.22092/ijmapr.2015.101874 | ||
| نویسندگان | ||
| صدیقه عسگری1؛ محمدرضا افشانی2؛ محمود رفعییان کوپائی3؛ مهتاب کشوری* 4 | ||
| 1استاد، مرکز تحقیقات قلب و عروق اصفهان، پژوهشکده قلب و عروق، دانشگاه علوم پزشکی اصفهان | ||
| 2متخصص قلب، گروه قلب و عروق، دانشکده پزشکی، دانشگاه علوم پزشکی و خدمات بهداشتی درمانی اصفهان | ||
| 3دانشیار، مرکز تحقیقات گیاهان دارویی، دانشگاه علوم پزشکی شهرکرد | ||
| 4کارشناس ارشد، مرکز تحقیقات قلب و عروق اصفهان، پژوهشکده قلب و عروق، دانشگاه علوم پزشکی اصفهان | ||
| چکیده | ||
| هیپرتانسیون یا فشار خون بالا از ریسک فاکتورهای مهم بیماری‌های قلبی عروقی می‌باشد، که سبب ایجاد حالت عدم کارآیی در آندوتلیال و افزایش سختی شریان می‌شود. آب انار سرشار از پلی‌فنل‌های فعال زیستی است که با عملکرد آنتی‌اکسیدانتی موجب محافظت از قلب و عروق می‌شود. این مطالعه به‌صورت یک کارآزمایی بالینی، یک سو کور، کنترل با دارونما به مدت دو هفته اجرا شد. 21 بیمار مبتلا به فشار خون بالا با محدوده سنی67-30 در مطالعه شرکت کردند. بیماران به‌طور تصادفی ساده به دو گروه کنترل، مصرف‌کننده آب (دارونما) (10 نفر) و گروه مورد مصرف‌کننده آب انار (11 نفر) نقسیم شدند. میزان فشار خون سیستولیک (SBP)، فشار خون دیاستولیک (DBP) و اختلال عملکرد جریان عروق (FMD)، همراه با سطح سرمی لیپید پروفایل و آپولیپوپروتئین A و B قبل و بعد از بررسی برای دو گروه تعیین گردید. داده‌ها توسط نرم‌افزار SPSS و با استفاده از آزمون‌های آماری تی‌زوج و تی‌مستقل بررسی شدند. میانگین SBP (002/0=p) و DBP (038/0=p) در گروه مصرف‌کننده PJ نسبت به گروه کنترل به‌طور قابل‌توجهی کاهش داشت، با این حال هیچ تفاوت معنی‌داری در میزان تغییرات FMD، لیپید پروفایل و آپولیپوپروتئین A و B بین دو گروه مشاهده نشد. مصرف آب انار موجب کاهش فشار خون می‌شود. البته مصرف آب انار می‌تواند در هر دو زمینه مداخلات رژیم غذایی و دارویی برای فشار خون بالا در نظر گرفته شود. | ||
| کلیدواژه‌ها | ||
| آب انار؛ بیماری‌های قلبی عروقی؛ فشار خون بالا؛ لیپید پروفایل | ||
| عنوان مقاله [English] | ||
| Clinical investigation of blood pressure lowering, endothelial function improving and hypolipidemic of pomegranate juice in hypertensive subjects | ||
| نویسندگان [English] | ||
| S. Asgary1؛ M.R. Afshani2؛ M. Rafieian-Kopaei3؛ M. Keshvari4 | ||
| 1Isfahan Cardiovascular Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, and Physiology Research Center, Isfahan University of Medical Sciences, Isfahan, Iran | ||
| 2Department of Cardiology, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran | ||
| 3Medical Plants Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran | ||
| 4Isfahan Cardiovascular Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran | ||
| چکیده [English] | ||
| Hypertension is a major risk factor for cardiovascular disease which is failure in endothelial function and increased arterial stiffness. Pomegranate juice is rich in bioactive polyphenols with antioxidant and cardioprotective functions. Twenty-one hypertensive patients (aged 30-67 years) were recruited into the trial and assigned to receive either PJ (150 ml/day in a single occasion between lunch and dinner; n=11) or the same amount of water (n=10) for a period of two weeks. Systolic blood pressure (SBP), diastolic blood pressure (DBP) and flow-mediated dilation (FMD), along with serum concentrations of lipid profile parameters and apolipoproteins A and B were measured at baseline and two weeks after PJ consumption. Statistical analysis was conducted using paired t-test for continuous variables. PJ consumption was associated with significant reductions in SBP (p=0.002) and DBP (p=0.038) but not FMD (p>0.05). However, no significant effect was observed from PJ on serum levels of lipid profile parameters and apolipoproteins. PJ has promising acute hypotensive properties. Consumption of PJ could be considered in the context of both dietary and pharmacological interventions for hypertension. | ||
| کلیدواژه‌ها [English] | ||
| Pomegranate juice, cardiovascular disease, hypertension, lipid profile | ||
| مراجع | ||
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