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Optimal Timing of Specimen Collection after Rash Onset for Diagnosis of Measles IgM Antibody | ||
| Archives of Razi Institute | ||
| مقاله 1، دوره 60، شماره 1، اردیبهشت 2005، صفحه 1-10 اصل مقاله (117.8 K) | ||
| شناسه دیجیتال (DOI): 10.22092/ari.2005.103729 | ||
| نویسندگان | ||
| T. Mokhtari Azad* ؛ M. Naseri؛ P. Yavari؛ M.M. Gooya؛ A. Esteghamati؛ R. Hamkar | ||
| چکیده | ||
| Antibody detection is the most versatile and commonly used method for measles diagnosis. Detection of specific IgM antibodies in a single serum specimen collected within the appropriate time after rash onset can provide a good presumptive diagnosis of current or recent measles infection and is the test of choice for rapid diagnosis of measles cases. So, optimal timing for collection of a single serum specimen to diagnose measles by IgM capture Enzyme Immunoassay (EIA) was evaluated. 399-paired sera were tested for measles IgM antibody. 149-paired sera were measles IgM negative. Two hundred fifty paired sera had at least one IgM positive. 223-paired sera were positive in both first and second samples. 19-paired sample were negative in first and positive in second sample and 8-paired sera were positive in the first and negative in the second samples. 85% and 100% of first specimens within 7 and 7-21 and 94% of all second samples were IgM positive at 28th days after rash onset, respectively. Analysis of data indicates that a single serum specimen collected between 7 to 27 days after rash onset can be used to diagnose most cases of measles with an IgM capture EIA. | ||
| کلیدواژهها | ||
| Measles؛ IgM Capture EIA؛ Optimal time | ||
| عنوان مقاله [English] | ||
| مناسبترین زمان جمع آوری نمونه بعد از شروع یکباره بیماری جهت تشخیص پادتن IgM سرخک | ||
| نویسندگان [English] | ||
| طلعت مختاری آزاد؛ م. ناصری؛ پ. یاوری؛ محمدمهدی گویا؛ ا. استقامتی؛ ر. همکار | ||
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