Asghari, A., Hashemzadeh Homaioni, B., Mortazavi, P., Jahandideh, A. (2016). Experimental study of the effect of metformin on corneal burn ulcer healing in rabbit. , 29(3), 110-117. doi: 10.22034/vj.2016.106438
A. Asghari; B. Hashemzadeh Homaioni; P. Mortazavi; A. Jahandideh. "Experimental study of the effect of metformin on corneal burn ulcer healing in rabbit". , 29, 3, 2016, 110-117. doi: 10.22034/vj.2016.106438
Asghari, A., Hashemzadeh Homaioni, B., Mortazavi, P., Jahandideh, A. (2016). 'Experimental study of the effect of metformin on corneal burn ulcer healing in rabbit', , 29(3), pp. 110-117. doi: 10.22034/vj.2016.106438
Asghari, A., Hashemzadeh Homaioni, B., Mortazavi, P., Jahandideh, A. Experimental study of the effect of metformin on corneal burn ulcer healing in rabbit. , 2016; 29(3): 110-117. doi: 10.22034/vj.2016.106438

Experimental study of the effect of metformin on corneal burn ulcer healing in rabbit

تحقیقات دامپزشکی و فرآورده‌های بیولوژیک
Article 7, Volume 29, Issue 3 - Serial Number 112, September 2016, Pages 110-117    PDF (1.45 M)
Document Type: Full Research Paper
DOI: 10.22034/vj.2016.106438
Authors
A. Asghari* 1; B. Hashemzadeh Homaioni2; P. Mortazavi3; A. Jahandideh1
1Department of Veterinary Surgery, Science and Research Branch, Islamic Azad University, Tehran, Iran
2Veterinary Graduate Student, Science and Research Branch, Islamic Azad University, Tehran, Iran
3Department of Veterinary Pathobiology, Science and Research Branch, Islamic Azad University, Tehran, Iran;
Abstract
This study was conducted to examine the effect of metformin on corneal burn wound healing in rabbit. In this study, 20 adult healthy male New Zealand rabbits were used with an average weight of 2.5-3 kg. After general anesthesia, corneal ulcer in the left eye of the all animals was induced. After returning from anesthesia, the rabbits were randomly divided into 4 groups of 5 numbers. Then the first group was gavaged with 50 mg/kg of metformin, the second group with 100 mg/kg and the third group with 200 mg/kg while the fourth group was gavaged with water for 21 days. In the day 21 after making a corneal ulcer, tissue samples were taken and evaluated histopathologically. According to the pathological results, the vascularization, inflammation and edema of matrix of cornea significantly diminished while the epithelium of cornea increased in metformin-treated rabbits compared to control group (P<0.05). Also, administration of metformin significantly improved the natural structure of cornea collagen fibers (P<0.05). Based on the results, it seems metformin has favorable effect on the healing process in rabbit’s corneal ulcer.
Keywords
Corneal ulcer; Metformin; NaOH; Rabbit
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