| تعداد نشریات | 285 |
| تعداد نشریات سازمان | 83 |
| تعداد شمارهها | 3,110 |
| تعداد مقالات | 34,666 |
| تعداد مشاهده مقاله | 49,822,530 |
| تعداد دریافت فایل اصل مقاله | 80,169,420 |
Autecology, Phytochemical and Antioxidant Activity of Peganum harmala L. Seed Extract in North of Iran (Tash Mountains) | ||
| Journal of Medicinal plants and By-products | ||
| مقاله 10، دوره 1، شماره 2، آذر 2012، صفحه 151-156 اصل مقاله (181.14 K) | ||
| شناسه دیجیتال (DOI): 10.22092/jmpb.2012.108479 | ||
| نویسندگان | ||
| Masoumeh Mazandarani* 1؛ Koushan Sineh Sepehr2؛ Behzad Baradaran2؛ Vahid Khuri3 | ||
| 1Department of Botany, Gorgan branch, Islamic Azad University, Gorgan, Iran | ||
| 2Immunology Research Center (IRC), University of Medical Sciences Tabriz, Iran | ||
| 3Golestan Medical Science University, Gorgan, Iran | ||
| چکیده | ||
| Peganum harmala L. (Zygophyllaceae) is one of the most important medicinal plants had been used in traditional medicine in North of Iran as anti parasite, anti inflammatiom, anti tumor and anti infection. The aim of this study was to evaluate of ecological factors , ethno pharmacology and record of the relationship between secondary metabolites content and their antioxidant activity in seeds extract of plant. Ecological factors and ethnopharmacological data were obtained in many field observation. The seeds were collected in Tash Mountainous region (2750m) in August 2011, dried and were extracted by ethanol solvent. Total phenolic (TP) and total flavonoids (TF) content were determined by spectrophotometry method. Total antioxidant capacity (TAC), 1, 1-diphenyl-2-picrylhydrazyl (DPPH) free radical scavenging assay and reducing power assay (RP) methods were applied to measure antioxidant activity. Field observation showed that Peganum harmala is a perennial plant which can grow 30 to 70 cm tall, somewhere with annual average rainfall about 197mm , in sandy clay loam soil . Flowers appeared in mid to late of May and fruit maturation occurred in June to July. The results demonstrated that the TP was 61.55±0.84 mg GAE g -1 and TF content 42.21±0.66 mg QUE g-1. IC50 was measured 53.64±0.5 mg/ml in DPPH 17.34±0.71 in TAC and 84.75±0.89 in RP method. Analyses of results showed a positive correlation between antioxidant activity and the most important secondary metabolites, which explains and confirmed the application of plant in traditional medicine as an antiseptic, anti-tumor and disinfectant agent. | ||
| کلیدواژهها | ||
| Peganum harmala L؛ Aut ecology؛ Secondary metabolites؛ Antioxidant activity؛ Ethnopharmacology؛ Iran | ||
| مراجع | ||
|
1. Mahmodian M, Jalilpour H, Salehian P. Toxicity of Peganum harmala,Review and a Case Report. Iranian J Pharmacol Therapeut. 2002;1:1-4.
2. Souri E, Amin G, Dehmobed-Sharifabad A, Nazifi A, Farsam H. Antioxidative Activity of Sixty Plants from Iran. Iranian J Pharmaceut Res. 2004;3:55-59.
3. Halliwell B. The antioxidant paradox. Lancet 2000; 355:1179-1180.
4. Cesquini M, Torsoni M A, Stoppa GR, Ogo SH. t-BOOH-induced oxidative damage in sickle red blood cells and the role of flavonoids. Biomed. Pharmacother. 2003;57:124-129.
5.Lai LS, Chou ST, Chao WW. Studies on the antioxidative activities of Hsian-tsao (Mesona procumbens Hemsl) leaf gum. J Agric Food Chem. 2001;49:963-968.
6. Hayet E, Maha M, Mata M, Mighri Z, Laurent G, Mahjoub A. Biological activities of Peganum harmala leaves. Afr J Biotechnol. 2010;9:8199-8205.
7. Jayaprakasha GK, Jaganmohan LR. Phenolic constituent from lichen Parmotrema stuppeum (Nyl.) Hale and their antioxidant activity. Zeitschrift fur Naturforschung. 2000;56:1018-1022.
8. Miliauskas G, Venskutonis PR, Beek TAV. Screening of radical scavenging activity of some medicinal and aromatic plant extracts. Food Chem. 2004;85:231-237.
9. Darabpor E, Bavi AP, Motamedi H, Nejad SMS. Antibacterial activity of different parts of Peganum harmala L. growin in Iran against multi-drug bacteri. EXCLI J. 2011;10:252-263.
10. Fathiazada FYA, Khodaie L. Pharmacological effects of Peganum harmala seeds extract on isolated rat uterus. Iranian J Pharmaceut Sci. 2006;2:81-86.
11. Arshad N, Neubauer C, Hasnain S, Hess M. Peganum harmala can minimize Escherichia coli infection in poultry, but long-term feeding may induce side effects. Poult Sci.2008;87: 240-249.
12. Bahmani M, Rafieian-Kopaei M, Parsaei P, Mohsenzadegan A. The anti-leech effect of Peganum harmala L. extract and some anti-parasite drugs on Limnatis nilotica. Afr J Microbiol Res. 2012;6: 2586-2590.
13. Fazal H, Ahmad N, Khan MA. Physicochemical, Phytochemical evaluation and DPPH scavenging antioxidant potential in medicinal plants used for herbal formulation in Pakistan. Pak. J. Bot.2011; 43: 63-67.
14. Bukhari N, Choi JH, Jeon CW, Park HW, Kim WH, Khan MA, Lee SH. Phytochemical Studies of the Alkaloids from Peganum Harmala. Appl Chem. 2008;12:101-104.
15. Astulla A, Zaima K, Matsuno Y, Hirasawa Y, Ekasar W, Widyawaruyanti A, Cholies-Zaini N, Morit H. Alkaloids from the seeds of Peganum harmala showing antiplasmodial and vasorelaxant activities. J. Nat. Med.2008;62:470-472.
16. Lala S, Pramanick S, Mukhopadhyay S, Bandyopadhyay S, Basu MK. Harmine: evaluation of its antileishmanial properties in various vesicular delivery systems. J Drug Target. 2004;12:165-175.
17. Akhtar MS, Iqbal Z, Khan MN, Lateef M. Anthelmintic activity of medicinal plants with particular reference to their use in animals in the Indo-Pakistan subcontinent. Small Ruminant Res. 2000;38:99-107.
18. Muhi-Eldeen Z, Al-Shamma K, Al-Hussainy T, Al-Kaissi E, Al-Daraji AM, Ibrahim H. Acute toxicological studies on the extract of Iraqi Peganum harmala in rats. Eur J Sci Res. 2008;22:494-500.
19. Goel N, SinghI N, Saini R. Efficient in vitro multiplication of Syrian Rue (Peganum harmala L.) using 6-benzylaminopurine pre-conditioned seedling explants. Nat Sci. 2009;7:129-34.
20. Asghari G, Lockwood GB. Stereospecific biotransformation of (±) phenylethyl propionate by cell cultures of Peganum harmala L. Iranian Biomed J.2002;6:43-46.
21. Shonoudam M, Osman S, Salama O, Ayoub A. Toxical effect of Peganum harmala L. leaves on the cotton leaf worm, Spodotera littoralis Boised and its parasitoids Microlitis refiventris Kok. Pak J Biol Sci.2008;11:546-552.
22. Arabshahi-Delou, Urooj A. Antioxidant properties of various solvent extracts of mulberry (Morus indica L.) leaves. Food Chem. 2007;102:1233-1240.
23. Pourmorad F, Hosseinimehr SJ, Shahabimajd N. Antioxidant activity, phenol and flavonoid contents of some selected Iranian medicinal plants. Afr J Biotechnol. 2006;5:1142-1145.
24. Tawaha KH, Alali FQ, Gharaibeh M, Mohammad M, Elimat TE. Antioxidant activity and total phenolic content of selected Jordanian plant species. Food Chem. 2007;104:1372-1378.
25. Mazandarani M , Zarghamin Moghadam P, Zolfaghari MR, Ghemi E. Effect of solvent type on TP and TF content and antioxidant activity in Onosma dichroanthum Boiss. in Golestan province, North of Iran. J Med Plant Res. 2012;28:4481-4488.
26. Mazandarani M, Majidi Z, Zarghamin Moghadam P, Abroudi M, Hemmati H, Fathi Azad F. Essential oil composition , TP, TF, Anthocyanin and antioxidant activity in different parts of Artemisia annua L. in two localities, North of Iran. J Med Plants By-prod. 2012;1:13-21.
27. Cai Y, Luo Q, Sun M, Corke H. Antioxidant activity and phenolic compounds of 112 traditional Chinese medicinal plants associated with anticancer. Life Sci. 2004;74:2157-2184.
28. Hadaruga DI, Hadauga NG. Antioxidant Activity of Hepatoprotective Silymarin and Silybum marianum L. Extract. Politehnica Univ. (Timisoara), 2009;54:2.
29. Mukarramshah SM, FA, Khan SM, Hassan Shah, KA, Chishti SM, Saifur Shah Pirzada M, Asif Khan AF. Evaluation of Phytochemicals and Antimicrobial Activity of White and Blue Capitulum and Whole Plant of Silybum marianum. World Appl Sci J. 2011;12:1139-1144.
30. Mazandarani M, Makari S, Baijan GR, Zarghami Moghadam P, Abroudi M. Evaluation of phytochemical and antioxidant activity in different parts of Heracleum gorganicum Rech.F. in Golestan province, North of Iran. Iranian J Plant Physiol. 2011;2:381-388.
31. Zarghami Moghadam P, Mazandarani M, Zolfaghari MR, Ghaemi. Anti bacterial and antioxidant activity in root extract of Onosma dichloroanthum Boiss. in North of Iran. Afr J Microbiol Res. 2012;6:1776-1781. | ||
|
آمار تعداد مشاهده مقاله: 1,096 تعداد دریافت فایل اصل مقاله: 1,087 |
||