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تأثیر همزمان شیره خشک گیاه استبرق (Calotropis procera (Willd.) R. Br.) و ویتامین C بر فاکتورهای سرمی موش‌های دیابتی نوع 1 | ||
| تحقیقات گیاهان دارویی و معطر ایران | ||
| مقاله 10، دوره 34، شماره 6 - شماره پیاپی 92، بهمن و اسفند 1397، صفحه 986-996 اصل مقاله (264.25 K) | ||
| نوع مقاله: مقاله پژوهشی | ||
| شناسه دیجیتال (DOI): 10.22092/ijmapr.2019.116279.2189 | ||
| نویسندگان | ||
| فریده ملائی نژاد1؛ فرشته عزتی قادی* 2؛ عبدالله رمضانی قرا2؛ سعید رضایی زارچی3 | ||
| 1دانشجوی کارشناسی ارشد بیوشیمی، دانشگاه پیام نور واحد تفت، یزد، ایران | ||
| 2استادیار، گروه زیست‌شناسی گیاهی، دانشکده علوم پایه، دانشگاه جیرفت، کرمان، ایران | ||
| 3استادیار، گروه زیست، دانشکده علوم پایه، دانشگاه پیام نور واحد تفت، یزد، ایران | ||
| چکیده | ||
| در این مطالعه سعی شد تا به خواص ضد دیابتی شیره خشک گیاه استبرق (Calotropis procera (Willd.) R. Br.) به همراه ویتامین C در موش‌های دیابتی شده توسط STZ پرداخته شود. دیابت در موش‌های بزرگ آزمایشگاهی توسط تک دوز STZ (50 میلی‌گرم/کیلوگرم وزن بدن) به‌صورت تزریق درون صفاقی ایجاد گردید. 30 سر موش نر بالغ نژاد ویستار به‌طور تصادفی به شش گروه به‌شرح زیر تقسیم شدند. گروه اول) کنترل، گروه دوم) دیابتی، گروه سوم) موش‌های دیابتی که با شیره استبرق200 میلی‌گرم به ازای کیلوگرم وزن بدن تیمار شدند، گروه چهارم) گروهی که توسط شیره استبرق (mg/kg200) و ویتامین C (mg/kg100) تیمار شدند، گروه پنجم) تیمار روزانه توسط شیره استبرق (mg/kg200)، گروه ششم) حیوانات این گروه روزانه با ویتامین C (mg/kg200) تیمار شدند. در پایان دوره 15 روزه فاکتورهای بیوشیمیایی قند خون، کلسترول تام، تری‌گلیسیرید و هموگلوبین گلیکه (HbA1c) بررسی شد. نتایج نشان داد که میزان قند خون، کلسترول تام، تری‌گلیسیرید و همگلوبین گلیکه (HbA1c) در گروه دیابتی به‌طور معنی‌داری افزایش داشته است. تیمار گروه‌های دیابتی توسط شیره خشک استبرق و همچنین ترکیب شیره استبرق و ویتامین C باعث کاهش معنی‌دار میزان فاکتورهای بیوشیمیایی بالا گردید. نتایج نشان داد که شیره استبرق به تنهایی نسبت به گروه چهارم تأثیر بهتری بر فاکتورهای بیوشیمیایی سرم داشته است. بنابراین می‌توان نتیجه گرفت که شیره خشک گیاه استبرق به تنهایی قادر به کاهش قند خون و همچنین عوارض ناشی از دیابت در افراد دیابتی نوع 1 می‌باشد. | ||
| کلیدواژه‌ها | ||
| هیپرگلیسمی؛ هیپرلیپیدمی؛ گیاه استبرق (Calotropis procera (Willd.) R. Br.)؛ ویتامین C | ||
| عنوان مقاله [English] | ||
| Simultaneous effects of Calotropis procera (Willd.) R. Br. dried latex and vitamin C on the serum factors of type 1 diabetic rats | ||
| نویسندگان [English] | ||
| F. Molahinejad1؛ F. Ezzati Ghadi2؛ A. Ramezani Ghara2؛ S, Rezaei Zarchi3 | ||
| 1M.Sc. student of Biochemistry, Payam-e-Noor University of Taft, Yazd, Iran | ||
| 2Department of Plant Biology, Faculty of Sciences, University of Jiroft, Jiroft, Iran | ||
| 3Department of Biology, Faculty of Sciences, Payam-e-Noor University of Taft, Yazd, Iran | ||
| چکیده [English] | ||
| The present study investigates the anti-diabetic properties of dried latex of Calotropis procera (Willd.) R. Br.with vitamin C in diabetic rats. Thirty adult male Wistar rats were randomly and equally divided into six groups as follow: first group) control, second group) diabetes was induced by a single dose of streptozotocin (50 mg/kg b.w by IP) , third group) diabetic rats were treated by 200 mg dried latex per kilogram of body weight, fourth group) the diabetic rats were treated by combined treatments of dried latex (200mg/kg) and vitamin C (100mg/kg) by gavage, fifth group) animals in this group were treated by (200mg/kg) dried latex daily and the sixth group) rats were treated by vitamin C (100mg/kg). After 15 days, the biochemical factors of blood sugar, triglyceride, total cholesterol, and glycated hemoglobin (HbAlc) were evaluated. Results showed that the amount of biochemical factors was increased significantly in the diabetic group.Dried latex and also the combined treatment of dried latex and vitamin C reduced the elevated levels of abovementioned biochemical factors. Moreover, the aqueous extract of dried latex compared to the group four, was more effective. In conclusion, the dried latex of Calotropis procera has anti-diabetic activity. | ||
| کلیدواژه‌ها [English] | ||
| Hyperglycemy, hyperlipidemy, Calotropis procera (Willd.) R. Br, vitamin C | ||
| مراجع | ||
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