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Evaluation the effects of aqueous and alcoholic extracts of Myrtus communis L. on tachyzoites of Toxoplasma gondii in vitro | ||
| تحقیقات گیاهان دارویی و معطر ایران | ||
| Article 10, Volume 35, Issue 2 - Serial Number 94, May and June 2019, Pages 276-290 PDF (288.73 K) | ||
| Document Type: Research Paper | ||
| DOI: 10.22092/ijmapr.2019.114713.2081 | ||
| Authors | ||
| H. Mirzaian1; F. Ghaffarifar* 2; J. Sadraei2; A. Abdoli3 | ||
| 1M.Sc. graduate, Department of Parasitology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran | ||
| 2Department of Parasitology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran | ||
| 3Department of Parasitology and Mycology, School of Medicine, Jahrom University of Medical Sciences, Jahrom, Iran | ||
| Abstract | ||
| Toxoplasmosis is one of the most common zoonotic infections worldwide. The aim of this study was to evaluate anti-Toxoplasma gondii activities of aqueous and alcoholic extracts of Myrtus communis L. in vitro. In this study, effects of aqueous and alcoholic extracts of M. communis on T. gondii-infected mouse macrophages were evaluated by MTT and direct method. The results showed that the aqueous extract of M. communis with concentrations of 12.5 and 25 µg/ml had the highest anti-T. gondii activity (87 and 81%), while their lethal effect on non-infected macrophage was less than other concentrations. The present study showed that the aqueous and alcoholic extracts of M. communis have a considerable inhibitory effect on Toxoplasma gondii tachyzoites and parasite intracellular proliferation in vitro. | ||
| Keywords | ||
| Toxoplasma gondii; toxoplasmosis; alcoholic extract; aqueous extract; Myrtus communis L | ||
| References | ||
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