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Novel Applications of Immuno-bioinformatics in Vaccine and Bio-product Developments at Research Institutes | ||
| Archives of Razi Institute | ||
| مقاله 2، دوره 74، شماره 3، آذر 2019، صفحه 219-233 اصل مقاله (715.91 K) | ||
| نوع مقاله: Review Article | ||
| شناسه دیجیتال (DOI): 10.22092/ari.2018.122523.1224 | ||
| نویسندگان | ||
| M. M. Ranjbar* 1؛ M. M. Ebrahimi2؛ S. Shahsavandi2؛ T. Farhadi3؛ A. Mirjalili4؛ M. Tebianian5؛ M. H. Motedayen5 | ||
| 1Department of FMD, Razi Vaccine and Serum Research Institute, Agricultural Research, Education and Extension Organization (AREEO), Karaj, Iran | ||
| 2Department of Avian Vaccine,Razi Vaccine and Serum Research Institute, Agricultural Research, Education and Extension Organization (AREEO), Karaj, Iran | ||
| 3Chronic Respiratory Diseases Research Center (CRDRC), National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran | ||
| 4Department of Genetics, Razi Vaccine and Serum Research Institute, Agricultural Research, Education and Extension Organization (AREEO), Karaj, Iran | ||
| 5Department of Serotherapy, Razi Vaccine and Serum Research Institute, Agricultural Research, Education and Extension Organization (AREEO), Karaj, Iran | ||
| چکیده | ||
| There are many challenges in the field of public health sciences. Rational decisions are required in order to treat different diseases, gain knowledge and wealth regarding research, and produce biological or synthetic products. Various advances in the basic laboratory science, computer science, and the engineering of biological production processes can help solve the occurring problems. Bioinformatics is defined as a field of science combined of biology, mathematics, physics, chemistry, and computer sciences. Recently, bioinformatics has been extensively used in the designing of the epitope, vaccines, antibodies, adjuvants, diagnostic kits, and therapeutic purposes (e.g., proteins, peptides, or small molecules). Moreover, bioinformatics includes chemoinformatics that has been employed to produce various biological or chemical products to target and combat pathogens. Bioinformatics is involved in other areas of data analysis and prediction, such as structural biology, system biology, phylogeny, population genetics, and next-generation data sequencing. To the best of our knowledge, no published study coherently described the benefits of bioinformatics fields applied for medication development or diagnostic aims in bio-productive and pharmaceutical/vaccine companies. Therefore, in the current review, we attempted to present the available bioinformatics resources, practical experiences, and other findings in the mentioned field along with providing a harmonized and applied model(s). The key points presented in the current review may help to elevate production and reduce the costs for the development of novel vaccines, medicines, and antibodies. In addition, these methods can facilitate the identification of organisms and may guarantee the quality of biological products. | ||
| کلیدواژه‌ها | ||
| Bioinformatics؛ Biological products؛ Immunoinformatics؛ Vaccine | ||
| عنوان مقاله [English] | ||
| کاربردهای نوین ایمونو-بیوانفورماتیک در توسعه واکسن و تولیدات زیستی در پژوهشگاه‌های تحقیقاتی | ||
| چکیده [English] | ||
| چالشهای بسیاری در زمینه سلامت عمومی مطرح میباشد. برای مثال جهت پیشگیری و درمان بیماریها، کسب دانش و ثروت به ویژه در حوزه تحقیق و تولید فرآوردههای بیولوژیک و سنتتیک تصمیمات منطقیتری میبایست اتخاذ شود. این چالشها سبب چاره اندیشی های خردمندانه‌ای بر اساس پیشرفت‌های برق آسای علوم پایه آزمایشگاهی، علم رایانه و مهندسی تولید میشود. علم بیوانفورماتیک ترکیبی از علوم بیولوژی، فیزیک-شیمی و کامیپوتر است و توانسته کاربرد گسترده در زمینه طراحی واکسنها، داروها، آنتیبادیها، ادجوانتها و غیره ارائه دهد. ایمونوانفورماتیک و کموانفورماتیک از زیر شاخه های علم بیوانفورماتیک بوده و به طور مستقیم در پروسههای مختلف تولید فرآوردههای بیولوژیک و شناخت و مبارزه با بیماریها دخیل میباشند. البته این دو حوزه علاوه بر تواناییهای ایجاد شده برای آنها، همچنین از حوزههای دیگر بیوانفورماتیک نظیر بیوانفورماتیک ساختاری، سیستم بیولوژی، فیلوژنی و ژنتیک جمعیت، و آنالیز دادههای نسل بعدی توالی یابی و غیره جهت نیل به اهداف خود بهره میبرند. منبع منسجم و مشخصی که بتواند علاوه بر معرفی، نحوه عملکرد این حوزههای بیوانفورماتیک را در تولید، تشخیص، پژوهش و تضمین کیفیت در موسسات بیولوژیکی تولید و شرکتهای داروئی/ واکسن مشخص کند موجود نمیباشد. در مقاله فعلی ما تلاش داریم براساس منابع موجود، تجربیات عملی در بخشهای مختلف و مقالات در این زمینه مدلی هماهنگ و کاربردی را در این زمینه فراهم آوریم. به طور ایده آل، نکات کلیدی که در این مقاله مروری به آنها اشاره می شود ممکن است به افزایش هر چه بیشتر میزان تولید واکسن، دارو، آنتی بادی، غیره و کاهش هرچه ممکن هزینههای این فرآیند کمک کند. به علاوه این روشهای نوین تسهیل تشخیص اورگانیسمها و شاید کیفیت فرآوردههای بیولوژیک را ضمانت میکنند. | ||
| کلیدواژه‌ها [English] | ||
| بیوانفورماتیک, ایمونوانفورماتیک, واکسن, فرآوردههای بیولوژیک | ||
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