| تعداد نشریات | 284 |
| تعداد نشریات سازمان | 82 |
| تعداد شماره‌ها | 3,081 |
| تعداد مقالات | 34,377 |
| تعداد مشاهده مقاله | 48,022,740 |
| تعداد دریافت فایل اصل مقاله | 78,931,748 |
Impact of Phytobacterial Agent on the Toxic Damage to the Liver and Ileum of White Rats | ||
| Archives of Razi Institute | ||
| مقاله 9، دوره 74، شماره 3، آذر 2019، صفحه 287-294 اصل مقاله (602.24 K) | ||
| نوع مقاله: Original Articles | ||
| شناسه دیجیتال (DOI): 10.22092/ari.2019.125886.1324 | ||
| نویسندگان | ||
| S. S. Tarmakova1؛ S. Y. Sanzhieva* 2؛ E. S. Nikolaeva3 | ||
| 1Testing Laboratory Center, Buryat State Agricultural Academy named after V. R. Filippov, Ulan-Ude, Russia | ||
| 2Department of Ecology, Subsoil Use and Life Safety, East Siberia State University of Technologiy and Management, Ulan-Ude, Russia | ||
| 3LLC Small Innovative Enterprise "Bifimed", Ulan-Ude, Russia | ||
| چکیده | ||
| Numerous pharmaceutical agents can induce adverse reactions in the human body, including toxicity to the liver and the inflammation of intestines. Therefore, nowadays one of the most urgent problems in modern medical science is the prevention and restoration of morphological and dysbiosis disorders caused by numerous medications. With this background in mind, we aimed to evaluate the efficacy of phytobacteria on toxic damage to the structure and function of the liver and ileum, as well as the composition of the large intestine microflora in white rats with intestinal dysbacteriosis due to carbon tetrachloride (CCl4) and ampicillin trihydrate. In order to prevent toxic damage to the liver and ileum of experimental animals, a phytobacterial agent was used. This test agent was composed of a mixture of commercial lactobacteria Lactobacillus helveticus with a water-soluble extract of thyme (Thymus Serpyllum L.) on a sterile milk basis. Our results showed that the introduction of phytobacterial agent led to reduced inflammation, accelerated regeneration of the ileum mucous membrane, and a positive effect on the damaged intestine. The phytobacterial agent increased the resistance of the body to potentially pathogenic microorganisms and toxic compounds by restoring the microflora of the large intestine. It was established that the phytobacterial remedy resulted in the normalization of the intestinal microflora of white rats, which had toxic damage to the liver and ileum caused by CCl4 and ampicillin trihydrate administration. Moreover, the usage of phytobacteria was correlated with improvement in the structure and function of the liver and ileum. | ||
| کلیدواژه‌ها | ||
| Dysbiosis؛ Ileum؛ Liver؛ Phytobacterium؛ Probiotics | ||
| عنوان مقاله [English] | ||
| ... | ||
| چکیده [English] | ||
| ... | ||
| کلیدواژه‌ها [English] | ||
| . | ||
| مراجع | ||
|
Aleshkin, V.A., Afanasyev, S.S., Pospelova, V.V., Vorobyev, A.A., Feklisova, L.V., Nesvizhsky, S.E., et al., 2005. The formation of probiotic therapy in Russia. Bull Russ Acad Med Sci 12, 3-13.
Aruin, L.I., Kapuller, L.L., Isakov, V.A., 1998. Morphological diagnosis of diseases of the stomach and intestines. Triada-X, Moscow.
Bondarenko, V.M., Gracheva, N.M., 2005. Disbiotic states and therapeutic measures with them. Bull Russ Acad Med Sci 12, 24-29.
Collins, M.D., Gibson, G.R., 1999. Probiotics, prebiotics, and synbiotics: approaches for modulating the microbial ecology of the gut. Am J Clin Nutr 69, 1052S-1057S.
Fedos'ina, E.A., Zharkova, M.S., Mayevskaya, M.V., 2009. Bacterial intestinal microflora and liver diseases. Russ J Gastroenterol, Hepatol and Coloproctol, 73-81.
Folwaczny, C., 2000. Probiotics for prevention of uncreative colitis recurrence: alternative medicine added to standard treatment. J Gastroenterol 38, 547-550.
Holt, J., 1997. Bergey's determinant of bacteria, in two volumes. Izdatel'stvo Mir. Moscow.
Ivashkin, V.T., Ivashkin, K.V., 2017. Intestinal microbiome as a factor in the regulation of the activity of the enteric and central nervous system. Russ J Gastroenterol, Hepatol and Coloproctol 5, 11-19.
Merkulov, G.A., 1969. Pathological and histological techniques. Meditsina, Leningrad.
Riordan, S.M., Williams, R., 2006. The intestinal flora and bacterial infection in cirrhosis. J Hepatol 45, 744-757.
Saulnier, D.M., Kolida, S., Gibson, G.R., 2009. Microbiology of the human intestinal tract and approaches for its dietary modulation. Curr Pharm Des 15, 1403-1414.
Steinbach, W.J., Shetty, A.K., 2001. Use of the diagnostic bacteriology laboratory: a practical review for the clinician. Postgrad Med J 77, 148-156.
Tarmakova, S.S., 1999. Structural and functional damages to the liver, intestine and their correction with phytobacterial and bifido-containing agents. Ulan-Ude.
Tarmakova, S.S., Tsybikova, L.A., Maksarova, D.D., 2010. Pharmacotherapeutic activity of phytobacterial agent possessing gastroprotective activity. Bull Buryat State Uni 14a, 293-301.
Vandenplas, Y., Benninga, M., 2009. Probiotics and functional gastrointestinal disorders in children. J Pediatr Gastroenterol Nutr 48, S107-109.
Vorobyev, A.A., 2004. Microecological disorders in clinical pathology and their correction with bifidobacteria-containing probiotics. Bull Russ Acad Med Sci 2, 3-17.
Zhou, W., Lv, H., Li, M.X., Su, H., Huang, L.G., Li, J., et al., 2015. Protective effects of bifidobacteria on intestines in newborn rats with necrotizing enterocolitis and its regulation on TLR2 and TLR4. Genet Mol Res 14, 11505-11514.
Zlatkina, A.R., 1999. Modern approaches to the correction of intestinal dysbiosis. Russ J Gastroenterol, Hepatol and Coloproctol 3, 64-67. | ||
|
آمار تعداد مشاهده مقاله: 2,083 تعداد دریافت فایل اصل مقاله: 2,820 |
||