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Ultrastructural and Echocardiographic Assessment of Chronic Doxorubicin-Induced Cardiotoxicity in Rats | ||
| Archives of Razi Institute | ||
| مقاله 10، دوره 75، شماره 1، خرداد 2020، صفحه 55-62 اصل مقاله (703.6 K) | ||
| نوع مقاله: Original Articles | ||
| شناسه دیجیتال (DOI): 10.22092/ari.2019.116862.1177 | ||
| نویسندگان | ||
| H. Babaei1، 2؛ N. Razmaraii* 1، 3؛ Gh. Assadnassab4؛ A. Mohajjel Nayebi2؛ Y. Azarmi2؛ D. Mohammadnejad1؛ A. Azami1، 5 | ||
| 1Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran | ||
| 2School of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran | ||
| 3Department of Cellular and Molecular Biotechnology, Razi Vaccine and Research Institute, Agricultural Research, Education, and Extension Organization, Karaj, Iran | ||
| 4Department of Veterinary Clinical Sciences, Tabriz Branch, Islamic Azad University, Tabriz, Iran | ||
| 5Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran | ||
| چکیده | ||
| Doxorubicin (DOX) is one of the secondary metabolites of Streptomyces peucetius var. caesius. It is a common and effective chemotherapeutic agent used for the treatment of different diseases, including lymphoma, leukemia, breast cancer, and solid tumors. However, this medicine causes cardiotoxic side effects, which limit its clinical application. The present study examined the cardiomyopathy induced by DOX via echocardiography and transmission electron microscopy (TEM). The main objective was to evaluate the capacity of echocardiography and TEM as diagnostic tools for DOX-induced cardiotoxicity. Moreover, the correlation between intracellular and functional changes due to cardiotoxicity was assessed in a rat model. Cardiomyopathy was induced in rats by two cumulative doses of DOX. Group I received DOX 12 [i.e., 12 mg/kg, intraperitoneal (IP)] and group II received DOX 15 (i.e., 15 mg/kg, IP) in six equal doses over two weeks. Group III as the control (Ctrl) group received normal saline as a vehicle. Mortality during the study was only observed in the DOX 15 group. The echocardiographic assessments revealed significant changes in ejection fraction, fractional shortening, and heart rate in the groups which received DOX. In addition, severe cardiac arrhythmia was evident in DOX-treated groups. Remarkable adverse effects, such as moderately degenerated cells and inflated mitochondria were observed in the TEM analysis of rat hearts in the DOX groups. The present study indicated that rat models are suitable for investigating DOX-induced cardiomyopathy, especially at the dose of 12 mg/kg. Furthermore, echocardiography and TEM examinations were found to be valuable methods for the determination of cardiotoxicity in rats due to DOX. | ||
| کلیدواژهها | ||
| Cardiomyopathy؛ Doxorubicin؛ Echocardiography؛ Electron microscopy؛ Rat heart | ||
| عنوان مقاله [English] | ||
| ارزیابی اکوکاردیوگرافیک و فرا یاخته ای کاردیومیوپاتی مزمن وابسته به دوکسوروبیسین در موش صحرایی | ||
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Bernard, Y., Ribeiro, N., Thuaud, F., Turkeri, G., Dirr, R., Boulberdaa, M., et al., 2011. Flavaglines alleviate doxorubicin cardiotoxicity: implication of Hsp27. PLoS One 6, e25302.
Blum, R.H., Carter, S.K., 1974. Adriamycin. A new anticancer drug with significant clinical activity. Ann Intern Med 80, 249-259.
Bu'Lock, F.A., Gabriel, H.M., Oakhill, A., Mott, M.G., Martin, R.P., 1993. Cardioprotection by ICRF187 against high dose anthracycline toxicity in children with malignant disease. Br Heart J 70, 185-188.
Cardinale, D., Bacchiani, G., Beggiato, M., Colombo, A., Cipolla, C.M., 2013. Strategies to prevent and treat cardiovascular risk in cancer patients. Semin Oncol 40, 186-198.
Childs, A.C., Phaneuf, S.L., Dirks, A.J., Phillips, T., Leeuwenburgh, C., 2002. Doxorubicin treatment in vivo causes cytochrome C release and cardiomyocyte apoptosis, as well as increased mitochondrial efficiency, superoxide dismutase activity, and Bcl-2:Bax ratio. Cancer Res 62, 4592-4598.
Goldberg, S.J., Hutter, J.J., Jr., Feldman, L., Goldberg, S.M., 1983. Two sensitive echocardiographic techniques for detecting doxorubicin toxicity. Med Pediatr Oncol 11, 172-177.
Ichikawa, Y., Ghanefar, M., Bayeva, M., Wu, R., Khechaduri, A., Naga Prasad, S.V., et al., 2014. Cardiotoxicity of doxorubicin is mediated through mitochondrial iron accumulation. J Clin Invest 124, 617-630.
Keizer, H.G., Pinedo, H.M., Schuurhuis, G.J., Joenje, H., 1990. Doxorubicin (adriamycin): a critical review of free radical-dependent mechanisms of cytotoxicity. Pharmacol Ther 47, 219-231.
Koh, E., Nakamura, T., Takahashi, H., 2004. Troponin-T and brain natriuretic peptide as predictors for adriamycin-induced cardiomyopathy in rats. Circ J 68, 163-167.
Krishnamurthy, B., Rani, N., Bharti, S., Golechha, M., Bhatia, J., Nag, T.C., et al., 2015. Febuxostat ameliorates doxorubicin-induced cardiotoxicity in rats. Chem Biol Interact 237, 96-103.
Lebrecht, D., Geist, A., Ketelsen, U.P., Haberstroh, J., Setzer, B., Walker, U.A., 2007. Dexrazoxane prevents doxorubicin-induced long-term cardiotoxicity and protects myocardial mitochondria from genetic and functional lesions in rats. Br J Pharmacol 151, 771-778.
Migrino, R.Q., Zhu, X., Pajewski, N., Brahmbhatt, T., Hoffmann, R., Zhao, M., 2007. Assessment of segmental myocardial viability using regional 2-dimensional strain echocardiography. J Am Soc Echocardiogr 20, 342-351.
Mohammadnejad, D., Abedelahi, A., Soleimani-Rad, J., Mohammadi-Roshandeh, A., Rashtbar, M., Azami, A., 2012. Degenerative effect of Cisplatin on testicular germinal epithelium. Adv Pharm Bull 2, 173-177.
Nagi, M.N., Mansour, M.A., 2000. Protective effect of thymoquinone against doxorubicin-induced cardiotoxicity in rats: a possible mechanism of protection. Pharmacol Res 41, 283-289.
Octavia, Y., Tocchetti, C.G., Gabrielson, K.L., Janssens, S., Crijns, H.J., Moens, A.L., 2012. Doxorubicin-induced cardiomyopathy: from molecular mechanisms to therapeutic strategies. J Mol Cell Cardiol 52, 1213-1225.
Razmaraii, N., Babaei, H., Mohajjel Nayebi, A., Asadnasab, G., Ashrafi Helan, J., Azarmi, Y., 2016a. Cardioprotective Effect of Phenytoin on Doxorubicin-induced Cardiac Toxicity in a Rat Model. J Cardiovasc Pharmacol 67, 237-245.
Razmaraii, N., Babaei, H., Mohajjel Nayebi, A., Assadnassab, G., Ashrafi Helan, J., Azarmi, Y., 2016b. Cardioprotective Effect of Grape Seed Extract on Chronic Doxorubicin-Induced Cardiac Toxicity in Wistar Rats. Adv Pharm Bull 6, 423-433.
Schwarz, E.R., Pollick, C., Dow, J., Patterson, M., Birnbaum, Y., Kloner, R.A., 1998. A small animal model of non-ischemic cardiomyopathy and its evaluation by transthoracic echocardiography. Cardiovasc Res 39, 216-223.
Shan, K., Lincoff, A.M., Young, J.B., 1996. Anthracycline-induced cardiotoxicity. Ann Intern Med 125, 47-58.
Takemura, G., Fujiwara, H., 2007. Doxorubicin-induced cardiomyopathy from the cardiotoxic mechanisms to management. Prog Cardiovasc Dis 49, 330-352.
Talas, Z.S., Ozdemir, I., Gok, Y., Ates, B., Yilmaz, I., 2010. Role of selenium compounds on tyrosine hydroxylase activity, adrenomedullin and total RNA levels in hearts of rats. Regul Pept 159, 137-141.
Tarr, A., Stoebe, S., Tuennemann, J., Baka, Z., Pfeiffer, D., Varga, A., et al., 2015. Early detection of cardiotoxicity by 2D and 3D deformation imaging in patients receiving chemotherapy. Echo Res Pract 2, 81-88.
Teraoka, K., Hirano, M., Yamaguchi, K., Yamashina, A., 2000. Progressive cardiac dysfunction in adriamycin-induced cardiomyopathy rats. Eur J Heart Fail 2, 373-378.
Tokarska-Schlattner, M., Zaugg, M., Zuppinger, C., Wallimann, T., Schlattner, U., 2006. New insights into doxorubicin-induced cardiotoxicity: the critical role of cellular energetics. J Mol Cell Cardiol 41, 389-405.
Wouters, K.A., Kremer, L.C., Miller, T.L., Herman, E.H., Lipshultz, S.E., 2005. Protecting against anthracycline-induced myocardial damage: a review of the most promising strategies. Br J Haematol 131, 561-578. | ||
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