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Role of magnetic Field in the Healing of Cutaneous Leishmaniasis Lesions in Mice | ||
| Archives of Razi Institute | ||
| مقاله 11، دوره 75، شماره 2، شهریور 2020، صفحه 227-232 اصل مقاله (207.88 K) | ||
| نوع مقاله: Original Articles | ||
| شناسه دیجیتال (DOI): 10.22092/ari.2019.123403.1246 | ||
| نویسندگان | ||
| M. Dastgheib1؛ M. Shaddel* 2؛ V. Saba3؛ M. M. Homayouni2؛ A. Fereydoni2 | ||
| 1Department of Dermatology, Razi Hospital, Faculty of Medicine, Tehran University of Medical Sciences and Health Services, Tehran, Iran | ||
| 2Department of Parasitology and Mycology, Faculty of Medicine, Aja University of Medical Sciences, Tehran, Iran | ||
| 3Department of Medical Radiology, Faculty of Paramedicine, Aja University of Medical Sciences, Tehran, Iran | ||
| چکیده | ||
| Leishmaniasisis an important tropical cutaneous disease that is endemic in the Middle East, including Iran. There is no consensus on the appropriate therapeutic method, dose, and duration for this disease. The pentavalent antimonial compounds are the first-line treatments of leishmaniasis. With regard to the resistance of this disease against drugs and its treatment failure in some patients, the present study was conducted to investigate the role of alternating magnetic field (AMF) in the treatment of cutaneous leishmaniasis lesionsin mice. To this end, 45 male Balb/c mice with the age of 3-4 weeks and weight of 18-20 g were purchased from the Pasteur Institute, Tehran, Iran, to be investigated. The mice were infected with Leishmania promastigote (2×106) injected in the upper end of the tail.After 3 weeks, the animals were screened for developing lesions. Finally, 15 mice were selected and randomly divided into three equal groups of positive control (treated with the standard drug), negative control (without treatment), and experimental (subjected to AMF at a frequency of 50 kHz for 30 min on a daily basis for 4 weeks). The subjects were followed up for 4 weeks, and the size of their lesions was measured weekly. The data were analyzed by repeated measures test in SPSS software (version 20) at a p-value of < 0.05. There was no significant difference between the experimental and positive control groups (P>0.05). However, the negative control group showed a significant difference with the positive control and experimental groups (P=0.0001). As the findings indicated, AMF was seemingly able to decrease the size of lesions to the same extent as the standard drug. Consequently, AMF could be suggested as a noninvasive and complementary tool against cutaneous leishmaniasis. However, it is required to perform more studies to address different aspects of this domain. | ||
| کلیدواژهها | ||
| Cutaneous leishmaniasis؛ Alternating magnetic field؛ Treatment | ||
| عنوان مقاله [English] | ||
| بررسی اثربخشی میدان مغناطیسی در بهبودی لیشمانیوز جلدی | ||
| چکیده [English] | ||
| لیشمانیازیس جلدی از مهمترین بیماریهای پوستی انگلی محسوب میگردد که مقاومت دارویی و عدم موفقیت در درمان زخمهای ناشی از آن ایجاد مشکلات عدیدهای را نموده است. در این راستا، طراحی مطالعه حاضر انجام گرفت که تاثیر میدان الکترو مغناطیس بر سیر بیماری لیشمانیازیس جلدی در موش حساس آزمایشگاهی را مورد ارزیابی قرار داد. این مطالعه به صورت تجربی روی موشهای Balb/C (نر، وزن 20 -18 گرم) انجام گرفت. ابتدا سعی در ایجاد آلودگی در آنها شد (با تزریق 106×2 مرحله پروماستیگوت انگل در انتهای ناحیه دم موش) و با گذشت مدت زمان 3 هفته بروز زخم در ناحیه تزریق پیگیری شده و در نهایت تعداد 15 موش زخم دار انتخاب شدند و به 3 گروه 5 تایی: شاهد منفی (بدون درمان)، شاهد مثبت (درمان با داروی استاندارد) و تجربی (درمان با تاثیر میدان مغناطیسی) تقسیم شدند و سیر بیماری لیشمانیازیس جلدی در آنها بر اساس ارزیابی اندازه زخمها به طور هفتگی و به مدت 4 هفته مورد بررسی قرار گرفت. میانگین اندازه زخمها بین 2 گروه تجربی و شاهد مثبت، تفاوت معناداری نداشت (P > 0.05)؛ اما بین گروه شاهد منفی با دو گروه تجربی و شاهد مثبت تفاوت معناداری وجود داشت(P=0.0001) .میدان مغناطیسی بر سیر بیماری لیشمانیازیس جلدی در موش حساس آزمایشگاهی balbC موثر بود و سبب بهبودی نسبی زخمهای لیشمانیازیس شد. با توجه به نتایج به دست آمده، مطالعات بیشتر روی جنبههای مختلف تاثیر میدان مغناطیسی توصیه میشود. | ||
| کلیدواژهها [English] | ||
| درمان, لیشمانیازیس جلدی, میدان مغناطیسی | ||
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