| تعداد نشریات | 284 |
| تعداد نشریات سازمان | 82 |
| تعداد شماره‌ها | 3,074 |
| تعداد مقالات | 34,301 |
| تعداد مشاهده مقاله | 47,134,944 |
| تعداد دریافت فایل اصل مقاله | 78,042,010 |
Interconnection between Adrenergic and Dopaminergic Systems in Feeding Behavior in Neonatal Chicks | ||
| Archives of Razi Institute | ||
| مقاله 18، دوره 76، شماره 2، شهریور 2021، صفحه 345-358 اصل مقاله (724.6 K) | ||
| نوع مقاله: Original Articles | ||
| شناسه دیجیتال (DOI): 10.22092/ari.2020.341240.1425 | ||
| نویسندگان | ||
| F Zanganeh1؛ N Panahi* 1؛ M Zendehdel2؛ A Asghari3 | ||
| 1Department of Basic Sciences, Faculty of Veterinary Medicine, Science and Research Branch, Islamic Azad University, Tehran, Iran | ||
| 2Department of Basic Sciences, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran | ||
| 3Department of Clinical Sciences, Faculty of Veterinary Medicine, Science and Research Branch, Islamic Azad University, Tehran, Iran | ||
| چکیده | ||
| Central dopaminergic (DAergic) and adrenergic systems have a prominent role in appetite regulation; however, their interaction(s) have not been studied in neonatal layer chickens.Therefore, the current study aimed to determine the interaction of central DAergic and noradrenergic systems in food intake regulation in neonatal layer chickens. In the first experiment, chickens received the intracerebroventricular (ICV) injection of a control solution, prazosin (i.e., α1 adrenergic receptor antagonist; 10 nmol), dopamine (DA; 40 nmol), and prazosin plus DA. The second to fifth experiments were similar to the first experiment except that the birds were injected with yohimbine (i.e., α2 receptor antagonist; 13 nmol), metoprolol (i.e., β1 adrenergic receptor antagonist; 24 nmol), ICI 118,551 (i.e., β2 adrenergic receptor antagonist; 5 nmol), and SR59230R (i.e., β3 adrenergic receptor antagonist; 20 nmol) instead of prazosin. In the sixth experiment, the chickens received ICV injection with the control solution and noradrenaline (NA; 75, 150, and 300 nmol). In the seventh experiment, the birds were injected with the control solution, SCH23390 (i.e., D1 DAergic receptor antagonist; 5 nmol), NA (300 nmol), and SCH23390 plus NA In the eighth experiment, the control solution, AMI-193 (i.e., D2 DAergic receptor antagonist; 5 nmol), NA (300 nmol), and AMI-193 plus NA were injected. Then, cumulative food intake was recorded at 30, 60, and 120 min after the injection. According to the obtained results, the ICV injection of DA (40 nmol) significantly decreased food intake in comparison to that reported for the control group (p <0.05). The co-injection of yohimbine plus DA significantly amplified DA-induced hypophagia in the neonatal chickens (p <0.05). In addition, the co-administration of ICI 118,551 plus DA significantly inhibited the hypophagic effect of DA in the neonatal chickens (p <0.05). Furthermore, NA (75, 150, and 300 nmol) significantly reduced food intake in a dose-dependent manner (p <0.05). The co-injection of SCH23390 plus NA decreased the hypophagic effect of NA in the neonatal chickens, compared to that reported for the control group (p <0.05). The co-injection of AMI-193 plus NA diminished NA-induced hypophagia, compared to that reported for the control group (p <0.05). The aforementioned results suggested that there is an interconnection between central DAergic and noradrenergic systems through α2/β2 adrenergic and D1/D2 DAergic receptors in food intake regulation in neonatal chicks. | ||
| کلیدواژه‌ها | ||
| Adrenergic؛ Dopamine؛ Food intake؛ Layer chicken | ||
| عنوان مقاله [English] | ||
| بررسی تداخل سیستم‌های دوپامینرژیک و آدرنرژیک مرکزی در تنظیم اخذ غذا در جوجه‌های نژاد تخمگذارD2 | ||
| چکیده [English] | ||
| سیستم‌های دوپامینرژیک و آدرنرژیک مرکزی نقش مهمی در تنظیم اشتها دارد اما تقابل عمل آنها در جوجه‌های تخمگذار بررسی نشده است. مطالعه حاضر به منظور بررسی سیستم‌های دوپامینرژیک و آدرنرژیک مرکزی در تنظیم اخذ غذا در جوجه‌های نژاد تخمگذار انجام گرفت. در آزمایش 1، جوجه-های 3 ساعت محروم از غذا، تزریقات داخل بطن مغزی (ICV) را به فرم زیر دریافت کردند: سالین، دوپامین (دوز 40 نانومول)، پرازوسین (آنتاگونیست گیرنده 1α ،10 نانومول) و دوپامین + پرازوسین. آزمایشات مراحل 2-5 مشابه آزمایش یک بود اما جوجه‌ها تزریق یوهمبین (آنتاگونیست گیرنده 2α، 13 نانومول)، متوپرولول (آنتاگونیست گیرنده 1β، دوز 24 میکروگرم)، ICI 118,551 (آنتاگونیست گیرنده 2β، دوز 15 نانومول) و SR 59230R (آنتاگونیست گیرنده 3β ، دوز 23 نانومول) را بجای پرازوسین دریافت کردند. در آزمایش 6، سالین، نور اپی نفرین (75 نانومول)، نور اپی نفرین (150 نانومول) و نور اپی نفرین (300 نانومول) تزریق شد. آزمایش 7، سالین، نور اپی نفرین (300 نانومول)، SCH23390 (آنتاگونیست گیرنده 1D دوپامینرژیک، دوز 5 نانومول) و نور اپی نفرین + SCH23390 تزریق شد. آزمایش 8، سالین، AMI-193 (آگونیست گیرنده‌های D2، 5 نانومول)، نور اپی نفرین (300 نانومول) و نور اپی نفرین + AMI-193 تزریق شد. سپس مصرف تجمعی غذا تا 120 دقیقه بعد از تزریق اندازه‌گیری شد. با توجه به نتایج بدست آمده، تزریق دوپامین (40 نانومول) موجب کاهش اخذ غذا شد (P≤0.05). تزریق توام yohimbin (13 نانومول) + دوپامین موجب تقویت اثرات هیپوفاژیک ناشی از دوپامین شد (P≤0.05). تزریق توام ICI 118,551 (5 نانومول) + دوپامین موجب مهار کاهش هیپوفاژیناشی از دوپامین شد (P≤0.05). مصرف غذا بواسطه تزریق داخل بطنی مغزی نورآدرنالین (75، 150 و 300 نانومول) به صورت وابسته به دوز کاهش یافت (P≤0.05). تزریق توام نورآدرنالین + SCH23390 موجب کاهش هیپوفاژی ناشی از نورآدرنالین شد (P≤0.05). تزریق توام AMI-193 + نورآدرنالین موجب مهار هیپوفاژی ناشی از نورآدرنالین شد (P≤0.05). نتایج نشان دهنده این بود که تقابل بین سیستم‌های آدرنرژیک و دوپامینرژیک از طریق گیرنده‌های 2α، 2β آدرنرژیک و D1و D2 دوپامینی در جوجه‌های تخمگذار میانجی‌گری می‌شود. | ||
| کلیدواژه‌ها [English] | ||
| سیستم دوپامینی, آدرنرژیک, اخذ غذا, جوجه تخمگذار | ||
|
سایر فایل های مرتبط با مقاله
|
||
| مراجع | ||
|
Baghbanzadeh, A., Hajinezhad, M.R., Shohreh, B., Maleklou, R., 2010. Intralateral hypothalamic area injection of isoproterenol and propranolol affects food and water intake in broilers. J Comp Physiol A Neuroethol Sens Neural Behav Physiol 196, 221-226.
Blevins, J.E., Stanley, B.G., Reidelberger, R.D., 2002. DMSO as a vehicle for central injections: tests with feeding elicited by norepinephrine injected into the paraventricular nucleus. Pharmacol Biochem Behav 71, 277-282.
Bungo, T., Shimojo, M., Masuda, Y., Choi, Y.-H., Denbow, D.M., Furuse, M., 1999. Induction of food intake by a noradrenergic system using clonidine and fusaric acid in the neonatal chick. Brain Research 826, 313-316.
Cadet, J.L., Jayanthi, S., McCoy, M.T., Beauvais, G., Cai, N.S., 2010. Dopamine D1 receptors, regulation of gene expression in the brain, and neurodegeneration. CNS Neurol Disord Drug Targets 9, 526-538.
Castelli, M.P., Spiga, S., Perra, A., Madeddu, C., Mulas, G., Ennas, M.G., et al., 2016. Alpha2A adrenergic receptors highly expressed in mesoprefrontal dopamine neurons. Neuroscience 332, 130-139.
Chopin, P., Colpaert, F.C., Marien, M., 1999. Effects of alpha-2 adrenoceptor agonists and antagonists on circling behavior in rats with unilateral 6-hydroxydopamine lesions of the nigrostriatal pathway. J Pharmacol Exp Ther 288, 798-804.
Cornil, C.A., Ball, G.F., 2008. Interplay among catecholamine systems: dopamine binds to α2-adrenergic receptors in birds and mammals. J Comp Neurol 511, 610-627.
Davis, J.L., Masuoka, D.T., Gerbrandt, L.K., Cherkin, A., 1979. Autoradiographic distribution of L-proline in chicks after intracerebral injection. Physiol Behav 22, 693-695.
Denbow, D.M., 1999. Food intake regulation in birds. J Exp Zool 283, 333-338.
Denbow, D.M., Cherry, J.A., Siegel, P.B., Van Krey, H.P., 1981. Eating, drinking and temperature response of chicks to brain catecholamine injections. Physiol Behav 27, 265-269.
Denbow, D.M., Sheppard, B.J., 1993. Food and water intake responses of the domestic fowl to norepinephrine infusion at circumscribed neural sites. Brain Res Bull 31, 121-128.
Drouin, C., Blanc, G., Villegier, A.S., Glowinski, J., Tassin, J.P., 2002. Critical role of alpha1-adrenergic receptors in acute and sensitized locomotor effects of D-amphetamine, cocaine, and GBR 12783: influence of preexposure conditions and pharmacological characteristics. Synapse 43, 51-61.
Ferrari, A.C., de Arruda Camargo, L.A., Saad, W.A.o., Renzi, A., De Luca, L.A., Menani, J., 1991. Role of theα1-andα2-adrenoceptors of the lateral hypothalamus in the dipsogenic response to central angiotensin II in rats. Brain Res 560, 291-296.
Furuse, M., Ando, R., Bungo, T., Shimojo, M., Masuda, Y., 1999. Intracerebroventricular injection of orexins does not stimulate food intake in neonatal chicks. Br Poult Sci 40, 698-700.
Furuse, M., Matsumoto, M., Saito, N., Sugahara, K., Hasegawa, S., 1997. The central corticotropin-releasing factor and glucagon-like peptide-1 in food intake of the neonatal chick. Eur J Pharmacol 339, 211-213.
Fuxe, K., Agnati, L.F., Marcoli, M., Borroto-Escuela, D.O., 2015. Volume Transmission in Central Dopamine and Noradrenaline Neurons and Its Astroglial Targets. Neurochem Res 40, 2600-2614.
GhandForoushan, M., Zendehdel, M., Babpour, V., 2017. Interactions between Histamine H1 and H3 and Dopamine D1 Receptors on feeding behavior in chicken. Iran J Vet Med 11, 63-73.
Guiard, B.P., El Mansari, M., Blier, P., 2008. Cross-talk between dopaminergic and noradrenergic systems in the rat ventral tegmental area, locus ceruleus, and dorsal hippocampus. Mol Pharmacol 74, 1463-1475.
Irwin, N., Hunter, K., Frizzell, N., Flatt, P.R., 2008. Antidiabetic effects of sub-chronic administration of the cannabinoid receptor (CB1) antagonist, AM251, in obese diabetic (ob/ob) mice. Eur J Pharmacol 581, 226-233.
Jonaidi, H., Noori, Z., 2012. Neuropeptide Y-induced feeding is dependent on GABAA receptors in neonatal chicks. J Comp Physiol A Neuroethol Sens Neural Behav Physiol 198, 827-832.
Kanzler, S.A., Januario, A.C., Paschoalini, M.A., 2011. Involvement of beta3-adrenergic receptors in the control of food intake in rats. Braz J Med Biol Res 44, 1141-1147.
Kuo, D.Y., 2002. Co-administration of dopamine D1 and D2 agonists additively decreases daily food intake, body weight and hypothalamic neuropeptide Y level in rats. J Biomed Sci 9, 126-132.
Lei, S., 2014. Cross interaction of dopaminergic and adrenergic systems in neural modulation. Int J Physiol Pathophysiol Pharmacol 6, 137-142.
Lin, Y., Quartermain, D., Dunn, A.J., Weinshenker, D., Stone, E.A., 2008. Possible dopaminergic stimulation of locus coeruleus alpha1-adrenoceptors involved in behavioral activation. Synapse 62, 516-523.
Madhavan, A., Argilli, E., Bonci, A., Whistler, J.L., 2013. Loss of D2 dopamine receptor function modulates cocaine-induced glutamatergic synaptic potentiation in the ventral tegmental area. J Neurosci 33, 12329-12336.
Nalepa, I., Kreiner, G., Bielawski, A., Rafa-Zabłocka, K., Roman, A., 2013. α1-Adrenergic receptor subtypes in the central nervous system: insights from genetically engineered mouse models. Pharmacol Rep 65, 1489-1497.
Olanrewaju, H., J.P, T., Dozier, W., Purswell, J., W.B, R., S.L, B., 2006. A Review of Lighting Programs for Broiler Production. Int J Poult Sci 5, 301-308.
Ozkan, M., Johnson, N.W., Sehirli, U.S., Woodhall, G.L., Stanford, I.M., 2017. Dopamine acting at D1-like, D2-like and alpha1-adrenergic receptors differentially modulates theta and gamma oscillatory activity in primary motor cortex. PLoS One 12, e0181633.
Parker, K.E., Johns, H.W., Floros, T.G., Will, M.J., 2014. Central amygdala opioid transmission is necessary for increased high-fat intake following 24-h food deprivation, but not following intra-accumbens opioid administration. Behav Brain Res 260, 131-138.
Qi, W., Ding, D., Salvi, R.J., 2008. Cytotoxic effects of dimethyl sulphoxide (DMSO) on cochlear organotypic cultures. Hear Res 236, 52-60.
Saito, E.S., Kaiya, H., Tachibana, T., Tomonaga, S., Denbow, D.M., Kangawa, K., et al., 2005. Inhibitory effect of ghrelin on food intake is mediated by the corticotropin-releasing factor system in neonatal chicks. Regul Pept 125, 201-208.
Sharkey, K.A., Darmani, N.A., Parker, L.A., 2014. Regulation of nausea and vomiting by cannabinoids and the endocannabinoid system. Eur J Pharmacol 722, 134-146. Tachibana, T., Sugahara, K., Ueda, H., Cline, M.A., 2009. Role of adrenergic alpha-2-receptors on feeding behavior in layer-type chicks. Gen Comp Endocrinol 161, 407-411.
Terry, P., Katz, J.L., 1992. Differential antagonism of the effects of dopamine D1-receptor agonists on feeding behavior in the rat. Psychopharmacology 109, 403-409.
Tsujii, S., Bray, G.A., 1998. A beta-3 adrenergic agonist (BRL-37,344) decreases food intake. Physiol Behav 63,723-728.
Van Tienhoven, A., Juhasz, L.P., 1962. The chicken telencephalon, diencephalon and mesencephalon in sterotaxic coordinates. J Comp Neurol 118, 185-197.
Volkow, N.D., Wang, G.J., Baler, R.D., 2011. Reward, dopamine and the control of food intake: implications for obesity. Trends Cogn Sci 15, 37-46.
Wellman, P.J., 1992. Overview of adrenergic anorectic agents. Am J Clin Nutr 55, 193S-198S.
Wellman, P.J., Davies, B.T., Morien, A., McMahon, L., 1993. Modulation of feeding by hypothalamic paraventricular nucleus α1- and α2-adrenergic receptors. Life Sci 53, 669-679.
Xing, B., Li, Y.C., Gao, W.J., 2016. Norepinephrine versus dopamine and their interaction in modulating synaptic function in the prefrontal cortex. Brain Res 1641, 217-233.
Yang, N., Zhang, K.Y., Wang, F.F., Hu, Z.A., Zhang, J., 2014. Dopamine inhibits neurons from the rat dorsal subcoeruleus nucleus through the activation of alpha2-adrenergic receptors. Neurosci Lett 559, 61-66.
Zendehdel, M., Hasani, K., Babapour, V., Mortezaei, S.S., Khoshbakht, Y., Hassanpour, S., 2014. Dopamine-induced hypophagia is mediated by D1 and 5HT-2c receptors in chicken. Vet Res Commun 38, 11-19.
Zendehdel, M., Hassanpour, S., 2014. Ghrelin-induced hypophagia is mediated by the beta2 adrenergic receptor in chicken. J Physiol Sci 64, 383-391.
Zendehdel, M., Parvizi, Z., Hassanpour, S., Baghbanzadeh, A., Hamidi, F., 2017. Interaction between Nociceptin/Orphanin FQ and Adrenergic System on Food Intake in Neonatal Chicken. Int J Pept Res Ther 23, 155-161. | ||
|
آمار تعداد مشاهده مقاله: 1,808 تعداد دریافت فایل اصل مقاله: 2,708 |
||
