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Farrokhi, R, Babapour, V, Zendehdel, M, Asghari, A, Gilanpour, H. (1400). Role of Dopaminergic and Cannabinoidergic Receptors on Ghrelin-Induced Hypophagia in 5-Day-Old Broiler Chicken. سامانه مدیریت نشریات علمی, 76(4), 935-948. doi: 10.22092/ari.2020.351261.1514
R Farrokhi; V Babapour; M Zendehdel; A Asghari; H Gilanpour. "Role of Dopaminergic and Cannabinoidergic Receptors on Ghrelin-Induced Hypophagia in 5-Day-Old Broiler Chicken". سامانه مدیریت نشریات علمی, 76, 4, 1400, 935-948. doi: 10.22092/ari.2020.351261.1514
Farrokhi, R, Babapour, V, Zendehdel, M, Asghari, A, Gilanpour, H. (1400). 'Role of Dopaminergic and Cannabinoidergic Receptors on Ghrelin-Induced Hypophagia in 5-Day-Old Broiler Chicken', سامانه مدیریت نشریات علمی, 76(4), pp. 935-948. doi: 10.22092/ari.2020.351261.1514
Farrokhi, R, Babapour, V, Zendehdel, M, Asghari, A, Gilanpour, H. Role of Dopaminergic and Cannabinoidergic Receptors on Ghrelin-Induced Hypophagia in 5-Day-Old Broiler Chicken. سامانه مدیریت نشریات علمی, 1400; 76(4): 935-948. doi: 10.22092/ari.2020.351261.1514

Role of Dopaminergic and Cannabinoidergic Receptors on Ghrelin-Induced Hypophagia in 5-Day-Old Broiler Chicken

Archives of Razi Institute
مقاله 23، دوره 76، شماره 4، آذر و دی 2021، صفحه 935-948    اصل مقاله (1.12 M)
نوع مقاله: Original Articles
شناسه دیجیتال (DOI): 10.22092/ari.2020.351261.1514
نویسندگان
R Farrokhi1؛ V Babapour* 2؛ M Zendehdel2؛ A Asghari3؛ H Gilanpour1
1Department of Basic Sciences, Faculty of Veterinary Medicine, Science and Research Branch, Islamic Azad University, Tehran, Iran
2Department of Basic Sciences, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran
3Department of Clinical Science, Faculty of Veterinary Medicine, Science and Research Branch, Islamic Azad University, Tehran, Iran
چکیده
The present study aimed to identify the role of dopaminergic and cannabinoidergic systems in the ghrelin-induced hypophagia among meat-type chickens. In the first experiment, intracerebroventricular (ICV) injection was applied to birds with control solution, D1 receptor antagonist (5 nmol), ghrelin (6 nmol), and D1 receptor antagonist plus ghrelin. The second to sixth experiments were similar to the first one, with the difference that D2 receptor antagonist (5 nmol), D3 receptor antagonist (6.4 nmol), D4 receptor antagonist (6 nmol), the precursor of dopamine (125 nmol), and 6-hydroxy dopamine (150 nmol) instead of D1 antagonist were injected into the broiler chickens. In experiment 7, control solution and different levels of ghrelin antagonists (5, 10, and 20 nmol) were injected. In experiment 8, the chickens were ICV injected with control solution, ghrelin antagonist (10 nmol), dopamine (40 nmol), and ghrelin antagonist plus dopamine. In experiments 9 and 10, CB1 and CB2 receptors antagonist (6.25µg and 5µg) were co-injected with ghrelin (6 nmol), respectively, measuring the food intake for 120 min after the injection. It was observed that ghrelin ICV injection considerably reduced food intake, whereas ghrelin antagonist increased food intake, depending on the dose (P<0.05). In addition, ghrelin-induced hypophagia was significantly attenuated by D1 receptor antagonist and 6-hydroxy dopamine (P<0.05), while the dopamine precursor considerably elevated the ghrelin-induced food intake (P<0.05). The dopamine-induced feeding behavior was diminished by the co-administration of [D-Lys-3]-GHRP-6 (10 nmol)+dopamine (40 nmol) (P<0.05). In addition, CB1 receptor antagonists enhanced the ghrelin influence on food intake (P<0.05). The results implied that the hypophagic impact of ghrelin was probably mediated by D1 and CB1 receptors within neonatal broilers.
کلیدواژه‌ها
Ghrelin؛ Cannabinoid؛ Dopamine؛ Broiler chicken؛ Food intake
عنوان مقاله [English]
نقش گیرنده های دوپامینرژیک و کانابینوئیدرژیک بر هیپوفاژی ناشی از گرلین در جوجه های گوشتی 5 روزه
چکیده [English]
مطالعه حاضر به منظور بررسی اندوکانابینوئیدرژیک و دوپامینرژیک مرکزی در کنترل اخذ غذای القا شده با گرلین در جوجه‌های گوشتی انجام گرفت. در آزمایش 1، جوجه‌های 3 ساعت محروم از غذا، تزریقات داخل بطن مغزی (ICV) را به فرم زیر دریافت کردند: سالین، SCH23390 (آنتاگونیست گیرنده 1D دوپامینرژیک، دوز 5 نانومول)، گرلین (6 نانومول) و SCH23390 + گرلین را دریافت کردند. آزمایشات مراحل 2-6 مشابه آزمایش یک بود اما جوجه‌ها تزریق AMI-193 (آنتاگونیست گیرنده‌های D2، 5 نانومول)، NGB2904 (آنتاگونیست گیرنده‌هایD3 ، 4/6 نانومول) و L-741,742 (آنتاگونیست گیرنده‌های D4 ، 6 نانومول) و L-DOPA (125 نانومول) و 6-OHDA (150 نانومول) را بجای SCH23390 دریافت کردند. در آزمایش 7، سالین، [D-Lys-3]-GHRP-6 (آنتاگونیست گرلین، 5، 10 و 20 نانومول) را دریافت کردند. در آزمایش 8، جوجه‌ها تزریق سالین، [D-Lys-3]-GHRP-6 (10 نانومول)، دوپامین (40 نانومول) و [D-Lys-3]-GHRP-6 + دوپامین را در یافت کردند. در آزمایش 9، سالین، SR141716A (آنتاگونیست گیرنده‌های CB1 ، 25/6 میکروگرم)، گرلین (6 نانومول) و SR141716A + گرلین را دریافت کردند. در آزمایش 10، سالین، AM630 (آنتاگونیست گیرنده‌هایCB2 ، 5 میکروگرم)، گرلین (6 نانومول) وAM630 + گرلین را دریافت کردند. سپس مصرف تجمعی غذا تا 120 دقیقه بعد از تزریق اندازه‌گیری شد. با توجه به نتایج بدست آمده، تزریق گرلین (6 نانومول) موجب کاهش اخذ غذا شد (P≤0.05). تزریق توام SCH23390 + گرلین موجب مهار کاهش اشتها ناشی از گرلین شد (P≤0.05). تزریق توام L-DOPA + گرلین موجب تقویت اثرات هیپوفاژیک ناشی از گرلین شد (P≤0.05). تزریق توام 6-OHDA + گرلین موجب مهار اثرات هیپوفاژیک ناشی از گرلین شد (P≤0.05). تزریق [D-Lys-3]-GHRP-6 بطور وابسته به دوز موجب افزایش اشتها شد (P≤0.05). درحالی‌که تزریق توام [D-Lys-3]-GHRP-6 + دوپامین موجب مهار اثرات هیپوفاژیک ناشی از دوپامین شد (P≤0.05). تزریق توام گرلین + SR141716A موجب مهار اثرات هیپوفاژیک ناشی از گرلین شد (P≤0.05). نتایج نشان دهنده این بود که تقابل بین سیستم‌های اندوکانابینوئیدرژیک و دوپامینرژیک و گرلین از طریق گیرنده‌های D1و CB1 در جوجه‌های گوشتی میانجی‌گری می‌شود.
کلیدواژه‌ها [English]
کانابینوئید, دوپامینرژیک, اخذ غذا, جوجه گوشتی
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مراجع
  1. Kaneko K, Yoshikawa M, Ohinata K. Novel orexigenic pathway prostaglandin D2-NPY system--involvement in orally active orexigenic delta opioid peptide. Neuropeptides. 2012;46(6):353-7.
  2. Cadet JL, Jayanthi S, McCoy MT, Beauvais G, Cai NS. Dopamine D1 receptors, regulation of gene expression in the brain, and neurodegeneration. CNS Neurol Disord Drug Targets. 2010;9(5):526-38.
  3. Madhavan A, Argilli E, Bonci A, Whistler JL. Loss of D2 dopamine receptor function modulates cocaine-induced glutamatergic synaptic potentiation in the ventral tegmental area. J Neurosci. 2013;33(30):12329-36.
  4. Volkow ND, Wang GJ, Baler RD. Reward, dopamine and the control of food intake: implications for obesity. Trends Cogn Sci. 2011;15(1):37-46.
  5. Zendehdel M, Ghashghayi E, Hassanpour S, Baghbanzadeh A, Jonaidi H. Interaction Between Opioidergic and Dopaminergic Systems on Food Intake in Neonatal Layer Type Chicken. Int J Pept Res Ther. 2016;22(1):83-92.
  6. Irwin N, Hunter K, Frizzell N, Flatt PR. Antidiabetic effects of sub-chronic administration of the cannabinoid receptor (CB1) antagonist, AM251, in obese diabetic (ob/ob) mice. Eur J Pharmacol. 2008;581(1-2):226-33.
  1. Xu P, Siegel PB, Denbow DM. Genetic selection for body weight in chickens has altered responses of the brain's AMPK system to food intake regulation effect of ghrelin, but not obestatin. Behav Brain Res. 2011;221(1):216-26.
  2. Kaiya H, Miyazato M, Kangawa K. Recent advances in the phylogenetic study of ghrelin. Peptides. 2011;32(11):2155-74.
  3. Richards MP. Genetic regulation of feed intake and energy balance in poultry. Poult Sci. 2003;82(6):907-16.
  4. Jonaidi H, Babapour V, Denbow DM. GABAergic control of food intake in the meat-type chickens. Physiol Behav. 2002;76(4-5):465-8.
  5. Kaiya H, Kangawa K, Miyazato M. What is the general action of ghrelin for vertebrates? - comparisons of ghrelin's effects across vertebrates. Gen Comp Endocrinol. 2013;181:187-91.
  6. Furuse M, Tachibana T, Ohgushi A, Ando R, Yoshimatsu T, Denbow DM. Intracerebroventricular injection of ghrelin and growth hormone releasing factor inhibits food intake in neonatal chicks. Neurosci Lett. 2001;301(2):123-6.
  7. Saito ES, Kaiya H, Tachibana T, Tomonaga S, Denbow DM, Kangawa K, et al. Inhibitory effect of ghrelin on food intake is mediated by the corticotropin-releasing factor system in neonatal chicks. Regul Pept. 2005;125(1-3):201-8.
  8. Zendehdel M, Hassanpour S. Ghrelin-induced hypophagia is mediated by the beta2 adrenergic receptor in chicken. J Physiol Sci. 2014;64(5):383-91.
  9. Shousha S, Nakahara K, Kojima M, Miyazato M, Hosoda H, Kangawa K, et al. Different effects of peripheral and central ghrelin on regulation of food intake in the Japanese quail. Gen Comp Endocrinol. 2005;141(2):178-83.
  10. Hassanpour S, Zendehdel M, Babapour V, Charkhkar S. Endocannabinoid and nitric oxide interaction mediates food intake in neonatal chicken. Br Poult Sci. 2015;56(4):443-51.
  11. Chen RZ, Frassetto A, Fong TM. Effects of the CB1 cannabinoid receptor inverse agonist AM251 on food intake and body weight in mice lacking mu-opioid receptors. Brain Res. 2006;1108(1):176-8.
  12. Alizadeh A, Zendehdel M, Babapour V, Charkhkar S, Hassanpour S. Role of cannabinoidergic system on food intake in neonatal layer-type chicken. Vet Res Commun. 2015;39(2):151-7.
  1. Emadi L, Jonaidi H, Hosseini Amir Abad E. The role of central CB2 cannabinoid receptors on food intake in neonatal chicks. J Comp Physiol A Neuroethol Sens Neural Behav Physiol. 2011;197(12):1143-7.
  2. Novoseletsky N, Nussinovitch A, Friedman-Einat M. Attenuation of food intake in chicks by an inverse agonist of cannabinoid receptor 1 administered by either injection or ingestion in hydrocolloid carriers. Gen Comp Endocrinol. 2011;170(3):522-7.
  3. Kern A, Mavrikaki M, Ullrich C, Albarran-Zeckler R, Brantley AF, Smith RG. Hippocampal Dopamine/DRD1 Signaling Dependent on the Ghrelin Receptor. Cell. 2015;163(5):1176-90.
  4. Kern A, Albarran-Zeckler R, Walsh HE, Smith RG. Apo-ghrelin receptor forms heteromers with DRD2 in hypothalamic neurons and is essential for anorexigenic effects of DRD2 agonism. Neuron. 2012;73(2):317-32.
  5. Salahpour A, Caron MG. Food for thought: the physiological relevance of ghrelin and dopamine D2 receptor heterodimerization in the regulation of appetite. Neuron. 2012;73(2):210-1.
  6. Skibicka KP, Shirazi RH, Hansson C, Dickson SL. Ghrelin interacts with neuropeptide Y Y1 and opioid receptors to increase food reward. Endocrinology. 2012;153(3):1194-205.
  7. Kalafateli AL, Vallof D, Jornulf JW, Heilig M, Jerlhag E. A cannabinoid receptor antagonist attenuates ghrelin-induced activation of the mesolimbic dopamine system in mice. Physiol Behav. 2018;184:211-9.
  8. Lim CT, Kola B, Feltrin D, Perez-Tilve D, Tschop MH, Grossman AB, et al. Ghrelin and cannabinoids require the ghrelin receptor to affect cellular energy metabolism. Mol Cell Endocrinol. 2013;365(2):303-8.
  9. Olanrewaju H, J.P T, Dozier W, Purswell J, W.B R, S.L B. A Review of Lighting Programs for Broiler Production. Int J Poult Sci. 2006;5.
  10. Blevins JE, Stanley BG, Reidelberger RD. DMSO as a vehicle for central injections: tests with feeding elicited by norepinephrine injected into the paraventricular nucleus. Pharmacol Biochem Behav. 2002;71(1):277-82.
  11. Qi W, Ding D, Salvi RJ. Cytotoxic effects of dimethyl sulphoxide (DMSO) on cochlear organotypic cultures. Hear Res. 2008;236(1-2):52-60.
  12. Davis JL, Masuoka DT, Gerbrandt LK, Cherkin A. Autoradiographic distribution of L-proline in chicks after
    intracerebral injection. Physiol Behav. 1979;22(4):693-5.
  13. Furuse M, Matsumoto M, Saito N, Sugahara K, Hasegawa S. The central corticotropin-releasing factor and glucagon-like peptide-1 in food intake of the neonatal chick. Eur J Pharmacol. 1997;339(2):211-3.
  14. Van Tienhoven A, Juhasz LP. The chicken telencephalon, diencephalon and mesencephalon in sterotaxic coordinates. J Comp Neurol. 1962;118:185-97.
  15. Furuse M, Ando R, Bungo T, Ao R, Shimojo M, Masuda Y. Intracerebroventricular injection of orexins does not stimulate food intake in neonatal chicks. Br Poult Sci. 1999;40(5):698-700.
  16. Asakawa A, Inui A, Kaga T, Katsuura G, Fujimiya M, Fujino MA, et al. Antagonism of ghrelin receptor reduces food intake and body weight gain in mice. Gut. 2003;52(7):947-52.
  17. Jonaidi H, Noori Z. Neuropeptide Y-induced feeding is dependent on GABAA receptors in neonatal chicks. J Comp Physiol A Neuroethol Sens Neural Behav Physiol. 2012;198(11):827-32.
  18. Chatfield C. The analysis of time series: an introduction. CRC: Chapman and Hall; 2003.
  19. Kojima M, Kangawa K. Ghrelin: structure and function. Physiol Rev. 2005;85(2):495-522.
  20. Date Y, Shimbara T, Koda S, Toshinai K, Ida T, Murakami N, et al. Peripheral ghrelin transmits orexigenic signals through the noradrenergic pathway from the hindbrain to the hypothalamus. Cell Metab. 2006;4(4):323-31.
  21. Cone JJ, McCutcheon JE, Roitman MF. Ghrelin acts as an interface between physiological state and phasic dopamine signaling. J Neurosci. 2014;34(14):4905-13.
  22. Dickson SL, Egecioglu E, Landgren S, Skibicka KP, Engel JA, Jerlhag E. The role of the central ghrelin system in reward from food and chemical drugs. Mol Cell Endocrinol. 2011;340(1):80-7.
  23. Quarta D, Di Francesco C, Melotto S, Mangiarini L, Heidbreder C, Hedou G. Systemic administration of ghrelin increases extracellular dopamine in the shell but not the core subdivision of the nucleus accumbens. Neurochem Int. 2009;54(2):89-94.
  24. Jerlhag E, Egecioglu E, Dickson SL, Engel JA. Glutamatergic regulation of ghrelin-induced activation of the mesolimbic dopamine system. Addict Biol. 2011;16(1):82-91.
  25. Maedeh G, Mehranfard N, Eliassi A, Alaei H. Modulation of the Plasma Ghrelin Level by Intraventromedial Hypothalamic Microinjection of D2 Receptors Agonist and Antagonist. Neuropsychiatry. 2018;08.
  1. Fuenzalida J, Galaz P, Araya KA, Slater PG, Blanco EH, Campusano JM, et al. Dopamine D1 and corticotrophin-releasing hormone type-2alpha receptors assemble into functionally interacting complexes in living cells. Br J Pharmacol. 2014;171(24):5650-64.
  2. Bernardi RE, Broccoli L, Hirth N, Justice NJ, Deussing JM, Hansson AC, et al. Dissociable Role of Corticotropin Releasing Hormone Receptor Subtype 1 on Dopaminergic and D1 Dopaminoceptive Neurons in Cocaine Seeking Behavior. Front Behav Neurosci. 2017;11:221.
  3. Diz-Chaves Y. Ghrelin, appetite regulation, and food reward: interaction with chronic stress. Int J Pept. 2011;2011:898450.
  4. Jiang H, Betancourt L, Smith RG. Ghrelin amplifies dopamine signaling by cross talk involving formation of growth hormone secretagogue receptor/dopamine receptor subtype 1 heterodimers. Mol Endocrinol. 2006;20(8):1772-85.
  5. Abizaid A. Ghrelin and dopamine: new insights on the peripheral regulation of appetite. J Neuroendocrinol. 2009;21(9):787-93.
  6. Senin LL, Al-Massadi O, Folgueira C, Castelao C, Pardo M, Barja-Fernandez S, et al. The gastric CB1 receptor modulates ghrelin production through the mTOR pathway to regulate food intake. PLoS One. 2013;8(11):e80339.
  7. Kola B, Farkas I, Christ-Crain M, Wittmann G, Lolli F, Amin F, et al. The orexigenic effect of ghrelin is mediated through central activation of the endogenous cannabinoid system. PLoS One. 2008;3(3):e1797.
  8. Turu G, Simon A, Gyombolai P, Szidonya L, Bagdy G, Lenkei Z, et al. The role of diacylglycerol lipase in constitutive and angiotensin AT1 receptor-stimulated cannabinoid CB1 receptor activity. J Biol Chem. 2007;282(11):7753-7.
  9. Perello M, Dickson SL. Ghrelin signalling on food reward: a salient link between the gut and the mesolimbic system. J Neuroendocrinol. 2015;27(6):424-34.
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