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بررسی فیتوشیمیایی عصاره کلروفرمی ساقه Ferula ovina Boiss. | ||
| تحقیقات گیاهان دارویی و معطر ایران | ||
| مقاله 3، دوره 36، شماره 4 - شماره پیاپی 102، مهر و آبان 1399، صفحه 542-551 اصل مقاله (424.34 K) | ||
| نوع مقاله: مقاله پژوهشی | ||
| شناسه دیجیتال (DOI): 10.22092/ijmapr.2020.128427.2671 | ||
| نویسندگان | ||
| صبا قاسمی* 1؛ زهره حبیبی2؛ فاطمه رضا علیزاده روشن3 | ||
| 1استادیار، گروه شیمی، واحد ایلام، دانشگاه آزاد اسلامی، ایلام، ایران | ||
| 2دانشیار، گروه شیمی، دانشکده علوم، دانشگاه شهید بهشتی، تهران، ایران | ||
| 3دانشجوی کارشناسی ارشد رشته شیمی، دانشکده علوم، دانشگاه شهید بهشتی، تهران، ایران | ||
| چکیده | ||
| شناسه دیجیتال (DOR): 98.1000/1735-0905.1399.36.542.102.4.1576.46 در این تحقیق، بررسی عصاره کلروفرمی ساقه گیاه Ferula ovina Boiss.از خانواده چتریان بررسی شد. این گونه گیاهی در فصل گلدهی از استان تهران- دماوندجمعآوری شد.پس از خالصسازی عصاره با استفاده از کروماتوگرافی ستونی بر روی سیلیکاژل با گرادیان حلال n- هگزان - اتیلاستات 12 جزء بدست آمد. در نتیجه خالصسازی بیشتر این فرکشنها، چهار مشتق استری مونوترپنوئیدی به نامهای شیمگین (1)، (S1،R2،S4)-1،7،7-تریمتیل بیسیکلو [2.2.1] هپتان-2-ایل 4-متوکسی بنزوآت (2)، (S1،R2،S4)-1،7،7-تریمتیل بیسیکلو [2.2.1] هپتان-2-ایل 4-هیدروکسی-3-متوکسی بنزوآت (3) و استیلوزین (4) جداسازی و شناسایی شد. البته تاکنون هیچگونه گزارشی مبنی بر جداسازی ساختار ترکیب شماره 2 یافت نشده است. ساختار ترکیبها توسط روشهای طیفسنجی تعیین شد. در نهایت از طریق مقایسه ویژگیهای فیزیکیشامل نقطهذوب و چرخش نوریو دادههای طیفی آنها با آنچه که در منابع علمی معتبر گزارش شده است تأیید گردید. | ||
| کلیدواژهها | ||
| فیتوشیمی؛ Ferula ovina Boiss؛ عصاره؛ مونوترپنوئید؛ شیمگین؛ استیلوزین | ||
| عنوان مقاله [English] | ||
| Phytochemical study on the chloroform extract of Ferula ovina Boiss. stems | ||
| نویسندگان [English] | ||
| S. Ghasemi1؛ Z. Habibi2؛ F. Rezaalizadeh Rooshan3 | ||
| 1Department of Chemistry, Ilam Branch, Islamic Azad University, Ilam, Iran | ||
| 2Department of Chemistry, Faculty of Chemistry, Shahid Beheshti University, Tehran, Iran | ||
| 3M.Sc. student, Department of Chemistry, Faculty of Chemistry, Shahid Beheshti University, Tehran, Iran | ||
| چکیده [English] | ||
| In this study, the chloroform extract of Ferula ovina (fam. Apiaceae) stems was investigated. The plants were collected at the flowering stage from Tehran province (Damavand), Iran. The extract was purified using column chromatography on silica gel with a solvent gradient of n-hexane-ethyl acetate and yielded 12 fractions. Further purification of the fractions resulted in the isolation and identification of four monoterpenoid ester derivatives named tschimgine (1), (1S,2R,4S)-1,7,7-trimethylbicyclo[2.2.1]heptan-2-yl 4-methoxy benzoate (2), (1S,2R,4S)-1,7,7-trimethylbicyclo[2.2.1]heptan-2-yl 4-hydroxy-3-methoxy benzoate (3) and stylosin (4). So far, no report has been found on the isolation and structure identification of the compound No.2. The structure of the compounds was determined by spectroscopic analysis andfinally confirmed by comparison of their spectral data, melting points, and optical rotations with those described in the literature. | ||
| کلیدواژهها [English] | ||
| Phytochemistry, Ferula ovina Boiss, extraction, monoterpenoid, tschimgine, stylosin | ||
| مراجع | ||
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