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Yan, Xiuying, Yan, Weihua, Chen, Meng, Dai, Liping, Jian, Jichang. (1399). Expression differences of interferon regulatory factor 3 and non-specific cytotoxic cell receptor protein-1 in grass carp (Ctenopharyngodon idella) after challenges with two genotypes of grass carp reovirus, and analysis of antiviral signaling pathways. سامانه مدیریت نشریات علمی, (), -. doi: 10.22092/ijfs.2020.122658
Xiuying Yan; Weihua Yan; Meng Chen; Liping Dai; Jichang Jian. "Expression differences of interferon regulatory factor 3 and non-specific cytotoxic cell receptor protein-1 in grass carp (Ctenopharyngodon idella) after challenges with two genotypes of grass carp reovirus, and analysis of antiviral signaling pathways". سامانه مدیریت نشریات علمی, , , 1399, -. doi: 10.22092/ijfs.2020.122658
Yan, Xiuying, Yan, Weihua, Chen, Meng, Dai, Liping, Jian, Jichang. (1399). 'Expression differences of interferon regulatory factor 3 and non-specific cytotoxic cell receptor protein-1 in grass carp (Ctenopharyngodon idella) after challenges with two genotypes of grass carp reovirus, and analysis of antiviral signaling pathways', سامانه مدیریت نشریات علمی, (), pp. -. doi: 10.22092/ijfs.2020.122658
Yan, Xiuying, Yan, Weihua, Chen, Meng, Dai, Liping, Jian, Jichang. Expression differences of interferon regulatory factor 3 and non-specific cytotoxic cell receptor protein-1 in grass carp (Ctenopharyngodon idella) after challenges with two genotypes of grass carp reovirus, and analysis of antiviral signaling pathways. سامانه مدیریت نشریات علمی, 1399; (): -. doi: 10.22092/ijfs.2020.122658

Expression differences of interferon regulatory factor 3 and non-specific cytotoxic cell receptor protein-1 in grass carp (Ctenopharyngodon idella) after challenges with two genotypes of grass carp reovirus, and analysis of antiviral signaling pathways

Iranian Journal of Fisheries Sciences
مقالات آماده انتشار، اصلاح شده برای چاپ، انتشار آنلاین از تاریخ 27 مهر 1399  XML اصل مقاله (1.02 MB)
نوع مقاله: Research Paper
شناسه دیجیتال (DOI): 10.22092/ijfs.2020.122658
نویسندگان
Xiuying Yan1؛ Weihua Yan1؛ Meng Chen2؛ Liping Dai1؛ Jichang Jian email 1
1Guangdong Ocean University
2The University of Texas MD Anderson Cancer Center
چکیده
Grass carp reovirus (GCRV), with high genetic diversity, seriously affects grass carp farming. Meanwhile, interferon regulatory factor 3 (IRF3) and non-specific cytotoxic cell receptor protein-1 (NCCRP-1) play crucial roles in immunity system of fish. In this paper, we took IRF3 and NCCRP-1 as molecular markers in order to explore the differences in immune responses of grass carp infected with different GCRV strains, which is helpful in better understanding of the GCRV pathogenesity. Accordingly, we analyzed the expression differences of IRF3 and NCCRP-1 in grass carp after challenges with GCRV GD108 (genotype III) and GCRV 096 (genotype I) by qRT-PCR. We found IRF3 and NCCRP-1 was up-regulated in all tested tissues after challenges of GCRV GD108 and GCRV 096. However, the expression levels of IRF3 and NCCRP-1 depended on the GCRV strain, and the up-regulation changes were qualitatively similar but quantitatively different after challenges of GCRV GD108 and GCRV 096, that is, NCCRP-1 was up-regulated more, earlier, and more broadly than IRF3 after GCRV challenge. Besides, the NCCRP-1 was more rapidly up-regulated to a greater extent after challenges with GCRV 096 than GCRV GD108. In order to clarify whether the antiviral immune response and development of grass carp hemorrhage in grass carp differed depending on GCRV genotypes needs more investigation. Moreover, we speculated that the GCRV-induced signaling pathways in grass carp were enriched with measles- and influenza A-induced signaling pathways, and found 13 types of new genes in the GCRV-induced signaling pathway.
کلیدواژه‌ها
Interferon regulatory factor 3 (IRF3)؛ Non-specific cytotoxic cell receptor protein-1 (NCCRP-1)؛ Grass carp (Ctenopharyngodon idella)؛ Grass carp reovirus (GCRV)
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تعداد مشاهده مقاله: 1
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