Seyedabadi,, H., Asgari Jafarabadi, G., Mahmoodi, A., Javaheri Barforosh, H. (2021). Effect of using flaxseed as omega-3 source on mammary gland growth and development gene expression in Saanen goat at their first pregnancy and lactation. , 34(4), 32-44. doi: 10.22092/vj.2020.351530.1755
H. R. Seyedabadi,; Gh. Asgari Jafarabadi; A. R Mahmoodi; H. Javaheri Barforosh. "Effect of using flaxseed as omega-3 source on mammary gland growth and development gene expression in Saanen goat at their first pregnancy and lactation". , 34, 4, 2021, 32-44. doi: 10.22092/vj.2020.351530.1755
Seyedabadi,, H., Asgari Jafarabadi, G., Mahmoodi, A., Javaheri Barforosh, H. (2021). 'Effect of using flaxseed as omega-3 source on mammary gland growth and development gene expression in Saanen goat at their first pregnancy and lactation', , 34(4), pp. 32-44. doi: 10.22092/vj.2020.351530.1755
Seyedabadi,, H., Asgari Jafarabadi, G., Mahmoodi, A., Javaheri Barforosh, H. Effect of using flaxseed as omega-3 source on mammary gland growth and development gene expression in Saanen goat at their first pregnancy and lactation. , 2021; 34(4): 32-44. doi: 10.22092/vj.2020.351530.1755

Effect of using flaxseed as omega-3 source on mammary gland growth and development gene expression in Saanen goat at their first pregnancy and lactation

تحقیقات دامپزشکی و فرآورده‌های بیولوژیک
Article 5, Volume 34, Issue 4, January 2022, Pages 32-44    PDF (1.5 M)
Document Type: Full Research Paper
DOI: 10.22092/vj.2020.351530.1755
Authors
H. R. Seyedabadi,* 1; Gh. Asgari Jafarabadi2; A. R Mahmoodi2; H. Javaheri Barforosh1
1Animal Science Research Institute of IRAN (ASRI), Agricultural Research Education and Extension Organization (AREEO), Karaj, Iran
2Department of Animal Science, Faculty of Agriculture, Varamin-Pishva Branch, Islamic Azad University, Tehran, Iran
Abstract
In order to investigate the effect of flaxseed consumption as a source of omega-3 fatty acids on the expression of genes effective in mammary gland tissue development in primiparous Sanan goats, 30 does (young female goats) in the second half of their first pregnancy were selected and divided into three groups of 10 based on their average initial live weight . One group received a diet without any fat source (negative control), the second group received a diet containing palm saturated fat (positive control) and the third group received extruded flaxseed (flax) as a source of omega-3. The diets of all three groups were adjusted according to the requirements of NRC 2007 dairy goats. Experimental groups received nutritional treatments from the last 2 months of pregnancy up to  4 months after parturition. During the experimental period, milk production was recorded weekly for each animal and mammary gland tissue sampling was performed three times, 24 to 36 hours after parturition, two and four months after parturition were performed to investigation the expression of IGF- 1, IGFBP3 and IGFBP5 genes. The results of this study showed that there was no significant difference among the treatments in terms of expression of the studied genes. Also, the interaction between treatment and time was not significant for any of the above genes and only the effect of time was significant for IGFBP-3 gene (P <0.05).
Keywords
Dairy goat; omega-3; milk production; breast tissue; gene expression
References

1-Javaheri Barforoush, H. 2016.The effect of omega3 nutrition the growth and development of breast tissue  to improve  lactation in pregnant dairy goats in the first abdomen.Final Report of the Research Project.ASRI.I
2-Abu-Ghazaleh, A. A., D. J. Schingoethe, A. R. Hippen, K. F. Kalscheur and L. A. Whitlock. 2002. Fatty acid profiles of milk and rumen digesta from cows fed fish oil, extruded soybeans or their blend. Journal of Dairy Science85: 2266-2276.
3-Akers, R. M., A. V. Capuco and J. E. Keys. 2006. Mammary histology and alveolar cell differentiation during late gestation and early lactation in mammary tissue of beef and dairy heifers. Livestock Science 105:44-49.
4-Akers, R.M., S.E. Ellis, S.D. Berry. 2005. Ovarian and IGF-I axis control of mammary development in prepubertal heifers. Domestic animal endocrinology. 29:259-267.
5-Allen, M. S. 2000. Effects of diet on short-term regulation of feed intake by lactating dairy cattle. Journal of Dairy Science 83:1598-1624.
6-Anderson, B.M., M.B. MacLennan., L.M. Hillyer and D.W Ma. 2014. Lifelong exposure to n-3 PUFA affects pubertal mammary gland development. Applied Physiology, Nutrition and Metabolism. 39:699-706.
7-Bao, Z., J, Lin., L, Ye., Q. Zhang., J. Chen., Q. Yang and Q. Yu. 2016. Modulation of mammary gland development and milk production by growth hormone expression in GH transgenic goats. Frontiers in physiology. 7:278-285.
8-Bauman, D.E., L. H. Baumgard, B.A.corl, and J. M. Griinari. 1999. Biosynthesis of conjugated linoleic acid in ruminants. Proceeding of the American society of animal science.
9-Bauman, D.E., I.H. Mather, R.J. Wall, and A.L. Lock. 2006. Major advances associated with the biosynthesis of milk. Journal of Dairy Science 89:1235-1243.
10-Bharathan, M., D. J. Schingoethe, A.R. Hippen, K. F. Kalscheur, M.L. Gibson and K. Karges. 2008. Conjugated linoleic acid increases in milk from cows fed condensed corn distillers solubles and fish oil. Journal of Dairy Science 91: 2796-2807.
11-Davis Rincker, L. E., M.S. Weber Nielsen., L.T. Chapin., J.S. Liesman., K.M. Daniels., R.M. Akers, and M.J. VandeHaar. 2008. Effects of feeding prepubertal heifers a high-energy diet for three, six or twelve weeks on mammary growth and composition. Journal of. Dairy Science. 91:1926-1935.
12-Dessauge, F., L. Fiont, S. Wiart, J. M. Aubry and S. E. Ellis. 2009. Effects of ovariectomy in prepubertal goats. J. Physiol. Pharmac. 60(Suppl.3): 127-133.
13-Didarkhah, M., M. Vatandoost, E. Dirandeh and N. Dadashpour Davachi. 2020. Effects of Flaxseed-rich Diet on Reproductive Performance in Estrous-synchronized Baluchi Ewes. Archives of Razi Institute. 75: 397-404.
14-FAO. 2012. Food and Agriculture organization of the United Nations. http://www.fao.org.
15-Fatahnia, F., A. Nikkhah, M. J. Zamiri and D. Kahrizi. 2008. Effect of dietary fish oil and soybeen oil on milk production and composition of Holstein cows in early lactation. Asian- Australian Journal of Animal Science 21: 386-391.
16-Finucane , K.A., T.B. McFadden., J.P. Bond., J.J. Kennelly and F.Q. Zhao. 2008. Onset of lactation in the bovine mammary gland: Gene expression profiling indicates a strong inhibition of gene expression in cell proliferation. Function Integration Genomics 8 : 251-264
17-Flint, D. J., M. Boutinaud, E. Tonner, C. J. Wilde, W. Hurley, P.A. Accorsi, A.F. Kolb, C. B. A. Whitelaw, J. Beattie, and G. J. Allan. 2005. Insulin-Like growth factor binding proteins initiate cell death and extracellular matrix remodeling in the mammary gland. Domestic Animal Endocology. 29: 274-282.
18-Heravi Mousavi, A. R., R.O. Gilbert, T.R. Overton, D. E.Bauman and W.R. Butler. 2007. Effects of feeding fish meal and n-3 fatty acids on milk yield and metabolic responses in early lactating dairy cows. Journal of Dairy Science 90: 136-144.
19-Hurley, W.L. 2009. Mammary gland anatomy of cattle. Lactation biology website.
20-Husvéth F. 2011. Physiological and reproductional aspects of animal production Master thesis, Debrecen University University of West Hungary, Pannon University. 
21-Leibowitz, B.J and Cohick, W.S. 2009. Endogenous IGFBP-3 is required for both growth factor-stimulated cell proliferation and cytokine-induced apoptosis in mammary epithelial cells. Journal of Cell Physiology. 220:182–8.
22-Livak, K. J., and T. D. Schmittgen. 2001. Analysis of relative gene expression data using real-time quantitative PCR and the 2− ΔΔCT method. Methods 25: 402-408.
23- Marshman,E., K.A. Green, D.J. Flint, A. White, C.H. Streuli, M. Westwood.2003.Insulin-like growth factor binding protein 5 and apoptosis in mammary epithelial cells. Journal of Cell Science 116: 675-682.
24-Mattos, R., C. R. Staples, J. Williams, A. Amorocho, M. A. McGuire and W.W. Tatcher. 2002. Uterine, ovarian, and production responses of lactating dairy cows to increasing dietary concentrations of menhaden fish meal. Journal of Dairy Science 85: 755-764.
25-Moallem, U. 2009. The effects of extruded flaxseed supplementation to high-yielding dairy cows on milk production and milk fatty acid composition. Animal Feed Science and Technology 152:232-242.
26-Nakagawa T., Sakamoto T., Hiraumi H., Kikkawa Y. S., Yamamoto N., Hamaguchi K., et al. 2010. Topical insulin-like growth factor 1 treatment using gelatin hydrogels for glucocorticoid-resistant sudden sensorineural hearing loss: a prospective clinical trial. BMC Med. 8:76 10.1186/1741-7015-8-76
27-Plath-Gabler, A., C. Gabler, F. Sinowatz, B. Berisha and D. Schams. 2001. The expression of the IGF family and GH receptor in the bovine mammary gland. Journal of Endocrinol. 168: 39-48.
28-Purup, S., M. Vestergaard., M.S. Weber., K. Plaut., R.M. Akers, and K. Sejrsen. 2000. Local regulation of pubertal mammary growth in heifers. Journal of Animal Science. 78(Suppl.3):36-47.
29-Sejrsen, K., S. Purup., M. Vestergaard and J. Foldager. 2000. High body weight gain and reduced bovine mammary growth: physiological basis and implications for milk yeild potential. Domestic animal endocrinology. 19:93-104.
30-Thibault, C., D. Petitclerc, R, Spratt, M. Leonard, K. Sejrsen, and P.Lacasse.2003.Effect of feeding prepubertal heifers with high oil diet on mammary development and milk production. Journal of Dairy Science 86:2320-2326.
31-Thomas, M. G., B. Bao and G. L. Williams. 1997. Dietary fats varying in their fatty acid composition differentially influence follicular growth in cows fed isoenergetic diets.Journal of Dairy Science75: 2512-2519.
32-Weber, M.S., S. Purup., M. Vestergaard., R.M. Akers and K. Sejersen. 2000. Nutritional and somatotropin regulation of mitogenic response of mammary cells to mammary tissue extracts. Domestic Animal Endocrinology. 18:159-164.

 

Statistics
Article View: 409
PDF Download: 559


counter
Journal management system. designed by sinaweb