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Amin, Mansour, Moghimipour, Eskandar, Pipelzadeh, Mohammad-Hassan, Handali, Somayeh, Yaghoobi, Mohammad-Reza, Farshadzadeh, Zahra. (1401). Physicochemical Characterization and Clinical Evaluation of Final Formulation of Shallomin Liposomal Gel on Cold Sore. سامانه مدیریت نشریات علمی, 11(Special), 43-49. doi: 10.22092/jmpb.2020.352432.1283
Mansour Amin; Eskandar Moghimipour; Mohammad-Hassan Pipelzadeh; Somayeh Handali; Mohammad-Reza Yaghoobi; Zahra Farshadzadeh. "Physicochemical Characterization and Clinical Evaluation of Final Formulation of Shallomin Liposomal Gel on Cold Sore". سامانه مدیریت نشریات علمی, 11, Special, 1401, 43-49. doi: 10.22092/jmpb.2020.352432.1283
Amin, Mansour, Moghimipour, Eskandar, Pipelzadeh, Mohammad-Hassan, Handali, Somayeh, Yaghoobi, Mohammad-Reza, Farshadzadeh, Zahra. (1401). 'Physicochemical Characterization and Clinical Evaluation of Final Formulation of Shallomin Liposomal Gel on Cold Sore', سامانه مدیریت نشریات علمی, 11(Special), pp. 43-49. doi: 10.22092/jmpb.2020.352432.1283
Amin, Mansour, Moghimipour, Eskandar, Pipelzadeh, Mohammad-Hassan, Handali, Somayeh, Yaghoobi, Mohammad-Reza, Farshadzadeh, Zahra. Physicochemical Characterization and Clinical Evaluation of Final Formulation of Shallomin Liposomal Gel on Cold Sore. سامانه مدیریت نشریات علمی, 1401; 11(Special): 43-49. doi: 10.22092/jmpb.2020.352432.1283

Physicochemical Characterization and Clinical Evaluation of Final Formulation of Shallomin Liposomal Gel on Cold Sore

Journal of Medicinal plants and By-product
دوره 11، Special، تیر 2022، صفحه 43-49    اصل مقاله (507.61 K)
نوع مقاله: Research Paper
شناسه دیجیتال (DOI): 10.22092/jmpb.2020.352432.1283
نویسندگان
Mansour Amin1، 2؛ Eskandar Moghimipour3، 4؛ Mohammad-Hassan Pipelzadeh5؛ Somayeh Handali5؛ Mohammad-Reza Yaghoobi6؛ Zahra Farshadzadeh* 1، 2
1Infectious and Tropical Diseases Research Center, Health Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
2Department of Microbiology, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
3Nanotechnology Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
4School of Pharmacy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
5Department of Pharmacology and Toxicology Research Centre, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
6Department of Dermatology, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
چکیده
Acyclovir is used locally or systemically to treat cold sore and totally have no side effect. However, this antiviral drug is not suitable for some people. The main aim of this study was to prepare and characterize shallomin liposomal hydrogel formulation and evaluation and comparison of dermal efficacy of this new formulation with acyclovir ointment on cold sores. Thin-Film Hydration was used to prepare liposome consisting of lecithin and cholesterol (molar ratio: 1:1). Morphology, size analysis and liposome encapsulation efficiency were determined. For preparation of hydrogel, Hydroxyethyl cellulose (HEC) was used. In vitro Skin permeation assay through abdominal region skin of male wistar rat was also determined. After preparing liposomal shallomin 1% in hydrogel a randomized controlled trial was performed on three groups (15 students in each groups) who showed cold sore within 24 hours. Liposomal shallomin gel, acyclovir and placebo was used every 6 hours for the first, second and third groups, respectively. The size of liposomal shallomin particles were 139±31.8 nm whereas polydispersity index values were 0.219 ± 0.01. The TEM images showed that the shape of particles was spherical and any aggregation or fusion were not seen. Furthermore, the particle size diameter was < 150 nm. The encapsulation capacity with the liposomes was approximately calculated 82.7%. The cold sore and tingling was disappeared in liposomal shallomin gel treated group within 0-12 hours in 12 cases (80%) and within 12-24 hours in 2 cases. In the acyclovir treated group, skin was cleared from cold sore in 8 cases (53%) within 24-48 hours after using drug. Regarding the obtained results, the liposomal shallomin gel caused a significant improvement in the removing cold sores within 12 hours related to acyclovir (P=0.001). Because mucoidal properties of hydrogel can facilitate adhesion between the shallomin and skin membrane, which extend keeping of shallomin at the site of administration and enhancing drug permeation so, liposomal shallomin gel is more effective treatment than shallomin extract and acyclovir with fewer side effects for cold sores treatment.
کلیدواژه‌ها
Cold sore؛ Acyclovir؛ Shallomin؛ Moosir؛ Liposome؛ Hydrogel
مراجع
  1. Jenssen H. Therapeutic Approaches Using Host Defence Peptides to Tackle Herpes Virus Infections.
  2. Haddad J, Messer J, Willard D, Ritter J. Aciclovir et grossesse: aspects actuels [Acyclovir and pregnancy: current aspects]. J Gynecol Obstet Biol Reprod (Paris). 1989;18:679-683.
  3. Yildiz C, Ozsurekci Y, Gucer S, Cengiz AB, Topaloglu R. Acute kidney injury due to acyclovir. CEN Case Rep. 2013;2:38-40
  4. Herpes. Use of complementary and alternative medicine for the treatment of genital herpes. Perfect MM, Bourne N, Ebel C, Rosenthal SL. 2005;12:38-41.
  5. Mozaffarian V. A Dictionary of Iranian Plant Names Tehran, Farhange Moaser Publications, Tehran, Iran. 1996.
  6. Amin M, Kapadnis BP. Heat stable antimicrobial activity of Allium ascalonicum against bacteria and fungi. Indian J Exp Biol. 2005;43:751-4.
  7. Amin M, Kapadnis BP. An investigation of antimicrobial properties of shallot. India: Ponan University. 2006.
  8. Ankri S, Mirelman D. Antimicrobial properties of allicin from garlic. Microbes Infection. 1999;1:2;125-129.
  9. Ariga T, Seki T. Antithrombotic and anticancer effects of garlic-derived sulfur compounds: a review. BioFactors. 2006;26:2;93-103.
  10. Harris JC, Cottrell S.L., Plummer S, Lloyd D. Antimicrobial properties of Allium sativum (garlic). Applied Microbiology Biotechnology. 2001;57:3;282-286.
  11. Taran M, Rezaeian M, Izaddoost M. Invitro antitrichomonas activity of Allium hirtifolium (persian shallot) in comparison with metronidazole. Iranian J Public Health. 2006;35:1;92-94.
  12. Abdou I.A., Abou-Zeid A.A., El-Sherbeeny M.R., Abou-El-Gheat Z.H. Antimicrobial activities of Allium sativum, Allium cepa, Raphanus sativus, Capsicum frutescens, Eruca sativa, Allium kurrat on bacteria. Qualitas Plantarum et Materiae Vegetabiles. 1972;22:1;29-35.
  13. Bordia A, Verma S.K., Khabia B.L., et al. The effective of active principle of garlic and onion on blood lipids and experimental atherosclerosis in rabbits and their comparison with clofibrate. J Association of Physicians of India.1977;25:8; 509-516.
  14. Eidi A, Eidi M, Esmaeili E. Antidiabetic effect of garlic (Allium sativum L.) in normal and streptozotocin-induced diabetic rats. Phytomedicine. 2006;13:9-10:624-629.
  15. Hirsch K, Danilenko M, Giat J, et al. Effect of purified allicin, the major ingredient of freshly crushed garlic, on cancer cell proliferation. Nutr and Cancer. 2000;38:2: 245-254.
  1. Kojuri J, Vosoughi A.R., Akrami M. Effects of anethum graveolens and garlic on lipid profile in hyperlipidemic patients. Lipids in Health Disease. 2007;6:5
  2. Lawson D.L. The composition and chemistry of garlic cloves and processed garlic, in Garlic. The Science and Therapeutic Applications of Allium Sativum L. and Related Species, H. P. Koch and D. L. Lawson, Eds. William & Wilkins, Baltimore, Md, USA. 1996; 37-107.
  3. Pipelzadeh M.H, Amin M, Shiravi Khozani A, Radmanesh M. Shallominthe Active Antimicrobial Constituent of Persian Shallot in Treatment of Oral Herpes. A Double-Blind Randomized Clinical Trial. Jundishapur J Nat Pharm Prod. 2014;9:e17372.
  4. Law SL, Shih CL. Characterization of calcitonin-containing liposomes formulations for intranasal delivery. J Microencapsul. 2001;18:211-221.
  5. Gulati M, Grover M, Singh M, Singh S. Study of azathioprine encapsulation into liposomes. J Microencapsul. 1998;15:485-494.
  6. Zupanc J, Drašler B, Boljte S, Kralj-Iglič V, Iglič A, et al. Lipid Vesicle Shape Analysis from Populations Using Light Video Microscopy and Computer Vision. PLOS ONE. 2014;9:e113405.
  7. Nguyen TL, Nguyen TH, Nguyen DH. Development and In Vitro Evaluation of Liposomes Using Soy Lecithin to Encapsulate Paclitaxel. International J Biomaterials. 2017; 8234712;7.
  8. Looker KJ, Magaret AS, Turner KME, Vickerman P, Gottlieb SL, et al. Correction: Global Estimates of Prevalent and Incident Herpes Simplex Virus Type 2 Infections in 2012. PLOS ONE. 2015;10:e0128615.
  9. Haddad J, Messer J, Willard D, Ritter J. Aciclovir et grossesse: aspects actuels [Acyclovir and pregnancy: current aspects]. J Gynecol Obstet Biol Reprod (Paris). 1989;18:679-683.
  10. Ismail S, Jalilian FA, Talebpour AH, Zargar M, Shameli K, Sekawi Z, et al. Chemical composition and antibacterial and cytotoxic activities of Allium hirtifolium Boiss. Biomed Res Int. 2013;2013:696835.
  11. Shahali S, Amin M, Khajeh Hassani M, Yaghoobi R, Saki M. Effects of shallomin and podophyllin solution 25% for genital HPV warts in women: a randomized controlled trial. J.Acute. Dis. 2019;8:118-122.
  12. Fateh R, Nasiri Kashani MJ, Motevallian M, Falahati M, Yazdanparast A. In vitro antifungal activity of Allium hirtifolium in comparison with miconazole. Med J Islam Repub Iran. 2010;24:17-22.
  13. Kaur A, Sharma G, Gupta V, Ratho RK, Katare OP. Enhanced acyclovir delivery using w/o type microemulsion: preclinical assessment of antiviral activity using murine model of zosteriform cutaneous HSV-1 infection. Artif Cells Nanomed Biotechnol. 2018;46:346-354.
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