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| تعداد نشریات | 278 |
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The Physiological Effect of Visfatin on Immune Response and Inflammatory Impacts on Nephropathy | ||
| Archives of Razi Institute | ||
| مقالات آماده انتشار، پذیرفته شده، انتشار آنلاین از تاریخ 18 مرداد 1400 اصل مقاله (557.6 K) | ||
| نوع مقاله: Original Articles | ||
| شناسه دیجیتال (DOI): 10.22092/ari.2021.355463.1688 | ||
| نویسنده | ||
R Muayad Shukur Al Obaidi 
| ||
| College of Medical and Health Technologies, Ahlulbyt University, Karbala, Iraq | ||
| چکیده | ||
| Obesity triggers the development of adipokines including leptin, resistin, and visfatin, which have been related to the development of diabetic nephropathy and other vascular disorders. The main purpose of the current investigation was to identify the physiological impact of visfatin on immunological response as well as the inflammatory effects of visfatin on nephropathy. We looked at fifty Iraqi patients with chronic kidney disease (CKD) at various stages, as described by the National Kidney Foundation (NKF), ranging in age from 48.367.56 to 53.68 8.46 years old on average. Prior to the start of this investigation, an informed consent form was completed, and the ethics committee gave their permission. All of the patients were classified into two groups, which were as follows: Patients in Group (A) had a GFR higher than 60 mL/minute. Patients in Group (B) had a GFR of less than 60 mL/min. There was no considerable variance between both groups as regard Visfatin in both groups, there was Highly Significant Correlation between serum visfatin and CRP. The current investigation reflects that, serum visfatin levels are significantly correlated with CRP in CKD patients and it is also correlated with deterioration of kidney function. On the other side higher visfatin levels were accompanied with increased serum triglyceride and cholesterol levels. These findings would suggest that visfatin may perform an essential function in uremia-related inflammation and may serve as a potential target for treatment and prevention of renal associated complications. Future studies may delineate whether visfatin is also a marker of disease activity and severity as well as a predictor of outcome in CKD. | ||
| کلیدواژه‌ها | ||
| Nephropathy؛ Obesity؛ Visfatin؛ Adipokines؛ Immune response | ||
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آمار تعداد مشاهده مقاله: 33 تعداد دریافت فایل اصل مقاله: 18 |
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