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Gattea Al-Rikabi, Z, H. Abbas, A, Kadhum Oudah, H, Sajer Nassir, H, A. Ali, S. (1400). Histopathological Study of Liver and Kidney Tissues in C57 Mouse via Chronic Exposure to Cadmium and Zinc. سامانه مدیریت نشریات علمی, (), -. doi: 10.22092/ari.2021.355622.1705
Z Gattea Al-Rikabi; A H. Abbas; H Kadhum Oudah; H Sajer Nassir; S A. Ali. "Histopathological Study of Liver and Kidney Tissues in C57 Mouse via Chronic Exposure to Cadmium and Zinc". سامانه مدیریت نشریات علمی, , , 1400, -. doi: 10.22092/ari.2021.355622.1705
Gattea Al-Rikabi, Z, H. Abbas, A, Kadhum Oudah, H, Sajer Nassir, H, A. Ali, S. (1400). 'Histopathological Study of Liver and Kidney Tissues in C57 Mouse via Chronic Exposure to Cadmium and Zinc', سامانه مدیریت نشریات علمی, (), pp. -. doi: 10.22092/ari.2021.355622.1705
Gattea Al-Rikabi, Z, H. Abbas, A, Kadhum Oudah, H, Sajer Nassir, H, A. Ali, S. Histopathological Study of Liver and Kidney Tissues in C57 Mouse via Chronic Exposure to Cadmium and Zinc. سامانه مدیریت نشریات علمی, 1400; (): -. doi: 10.22092/ari.2021.355622.1705

Histopathological Study of Liver and Kidney Tissues in C57 Mouse via Chronic Exposure to Cadmium and Zinc

Archives of Razi Institute
مقالات آماده انتشار، پذیرفته شده، انتشار آنلاین از تاریخ 09 شهریور 1400  XML اصل مقاله (832.85 K)
نوع مقاله: Original Articles
شناسه دیجیتال (DOI): 10.22092/ari.2021.355622.1705
نویسندگان
Z Gattea Al-Rikabi؛ A H. Abbas email ؛ H Kadhum Oudah؛ H Sajer Nassir؛ S A. Ali
Ministry of Sciences and Technology, Environment and Water Directorate, Baghdad, Iraq
چکیده
In the industrial world, heavy metals are commonly used. These elements have some effects on health and longevity of living organisms. In the current study the possible effects of Cadmium (Cd) and Zinc (Zn) on liver and kidney were investigated. Therefore, 150 male and female white mice C57BL were treated in three different groups with 0.685 mg/L CdCl2. 2.5H2O (group 1) and 0.567 mg/L ZnSO4.7H2O (group 2) in drinking water and the Control group only received water for 90 days to investigate how these elements accumulated in the liver/kidney, and evaluate the possible histological changes in the liver and kidney. During a period of 90 days in this experiment, the histopathological consequences of Cd and Zn on the liver and kidneys were recorded. The results showed that exposure to heavy metals, Cd and Zn, led to organ accumulation of these elements. The histological evaluations showed significant detrimental effects on the liver and kidney. Under Cd's influence, light microscopic examination revealed significant histological alterations in both organs. In the animals exposed to Cd and Zn, histopathological alterations in the liver include extensive degeneration, necrosis, depletion, and necrosis of hepatocytes with significant nuclear hypertrophy. When animals are exposed to Cd and Zn, histological alterations in the kidneys include severe vascular degeneration and renal tubule necrosis. In conclusion, heavy metal intoxication has been shown to cause histopathological changes in the liver and kidneys of experimental animal models.
کلیدواژه‌ها
Heavy metal؛ accumulation؛ Liver؛ Kidney؛ histopathology
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تعداد مشاهده مقاله: 14
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