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Investigation of Antioxidant Markers in Diabetic Patients | ||
| Archives of Razi Institute | ||
| مقالات آماده انتشار، پذیرفته شده، انتشار آنلاین از تاریخ 11 شهریور 1400 اصل مقاله (435.36 K) | ||
| نوع مقاله: Original Articles | ||
| شناسه دیجیتال (DOI): 10.22092/ari.2021.355755.1717 | ||
| نویسندگان | ||
M Adnan khalaf  ؛ I Ghassan Zainal
| ||
| Chemistry Department, College of Science, University of Kirkuk, Iraq | ||
| چکیده | ||
| Hyperglycemia is a characteristic of diabetes mellitus, one of the most common metabolic illnesses in the world, and is caused by either reduced insulin secretion or insulin resistance. Diabetes mellitus in adults has been on the rise in recent decades, and it is now the world's fifth biggest cause of mortality. Diabetes mellitus will affect 592 million people worldwide by 2035, according to the International Diabetes Mellitus Federation. Acute and chronic diabetic complications are the two types of complications. Diabetic ketoacidosis, nonketotic hyperosmolar coma, and hypoglycemia are examples of acute problems, whereas chronic complications include injuries to the tiny (microvascular issues) and big blood arteries (macrovascular complications). Diabetic neuropathy, retinopathy, and nephropathy all have microvascular consequences. Macrovascular problems, on the other hand, have a role in the etiology of cardiovascular disorders such as coronary, cerebrovascular, and peripheral artery disease. This study aimed to estimate some antioxidant markers including (total protein, albumin, globulin, albumin/globulin ratio, free amino, free amino / total protein, thiol, thiol/ total protein, carbonyl and carbonyl/ total protein) level in plasma of diabetic complications compared to healthy subjects and investigating the correlation between them. This study included 120 plasma samples divided into 80 samples as patients with diabetic complications including 26 sample diabetic kidney disease , 26 sample diabetic retinopathy , 28 sample diabetic neuropathy with age ranges between 20-60 year-olds and 40 healthy subjects as control group with the same age ranges. The results showed that there was not any significant difference in carbonyl. While significant differences were recorded in the total protein, albumin, globulin, albumin/globulin ratio, free amino, free amino / total protein, thiol and thiol/ total protein, carbonyl /total protein levels in all studied groups. The outcomes of correlation stated that there was recorded significant positive relationship between total protein - globulin, albumin\globulin ratio –albumin, and free amine –albumin. While the significant negative correlation was recorded between total protein - albumin\globulin ratio and albumin\globulin ratio -globulin in diabetic complications. The study concluded that oxidation markers may play role in monitoring the diabetic complications. | ||
| کلیدواژه‌ها | ||
| Diabetic complications؛ Total protein؛ Antioxidant markers | ||
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آمار تعداد مشاهده مقاله: 7 تعداد دریافت فایل اصل مقاله: 9 |
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