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Saeed, B., Al-Jadaan, S., Abbas, B. A. (1400). Study on Anticancer Activity of 4, 4'-[1,4-phenylenebis(1,3,4-thiadiazole-5,2-diyl)] bis(azaneylylidene) bis(methaneylylidene) diphenolon Breast Cancer Cells. سامانه مدیریت نشریات علمی, 76(4), 821-827. doi: 10.22092/ari.2021.355941.1742
B. M. S Saeed; S. A. N Al-Jadaan; B. A Abbas. "Study on Anticancer Activity of 4, 4'-[1,4-phenylenebis(1,3,4-thiadiazole-5,2-diyl)] bis(azaneylylidene) bis(methaneylylidene) diphenolon Breast Cancer Cells". سامانه مدیریت نشریات علمی, 76, 4, 1400, 821-827. doi: 10.22092/ari.2021.355941.1742
Saeed, B., Al-Jadaan, S., Abbas, B. A. (1400). 'Study on Anticancer Activity of 4, 4'-[1,4-phenylenebis(1,3,4-thiadiazole-5,2-diyl)] bis(azaneylylidene) bis(methaneylylidene) diphenolon Breast Cancer Cells', سامانه مدیریت نشریات علمی, 76(4), pp. 821-827. doi: 10.22092/ari.2021.355941.1742
Saeed, B., Al-Jadaan, S., Abbas, B. A. Study on Anticancer Activity of 4, 4'-[1,4-phenylenebis(1,3,4-thiadiazole-5,2-diyl)] bis(azaneylylidene) bis(methaneylylidene) diphenolon Breast Cancer Cells. سامانه مدیریت نشریات علمی, 1400; 76(4): 821-827. doi: 10.22092/ari.2021.355941.1742

Study on Anticancer Activity of 4, 4'-[1,4-phenylenebis(1,3,4-thiadiazole-5,2-diyl)] bis(azaneylylidene) bis(methaneylylidene) diphenolon Breast Cancer Cells

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مقاله 12، دوره 76، شماره 4، آذر و دی 2021، صفحه 821-827    اصل مقاله (440.51 K)
نوع مقاله: Original Articles
شناسه دیجیتال (DOI): 10.22092/ari.2021.355941.1742
نویسندگان
B. M. S Saeed* 1؛ S. A. N Al-Jadaan2؛ B. A Abbas3
1University of Basrah, Al-Zahraa College of Medicine, Microbiology Department, Basrah, Iraq
2University of Basrah, College of Pharmacy, Pharmaceutical Chemistry Department, Basrah, Iraq
3Department of Microbiology, College of Veterinary Medicine, University of Basrah, Basrah, Iraq
چکیده
New medicinal compounds are being evaluated due to the increasing prevalence of cancer in human societies and the necessity to produce new medications for treatment. The new Schiff base compound 4,4'-[1,4-phenylenebis(1,3,4-thiadiazole-5,2-diyl)] bis (azaneylylidene) bis (methaneylylidene) diphenol, which was previously produced from the reaction of 5,5' [(1,4-Phenelene) bis (1,3,4-thiadiazol-2-amine)] and the para-hydroxy ben aldehyde was synthesized and different concentrations (250 and 300 mg/mL) of this new compound were exposed to breast cancer (MCF-7) cells to examine its cytotoxicity effect. Cell line viability, acridine orange/propidium iodide staining, and DNA fragmentation were assessed in evaluating the antitumor effect of the new composition. Obtained data from cell viability assays demonstrated cytotoxic activity against MCF-7 breast cancer cell lines. No fragmentation was observed in DNA fragmentation of the novel compound base with MCF-7 and Vero cell line. The new Schiff base compound indicated well-defined anti-cancer activity when treated with breast cancer cells (MCF-7). The compound blocked the proliferation of cancer cells without apoptosis. As a consequence of the findings, it was recommended to use this compound in treating breast cancer.
کلیدواژه‌ها
Breast Cancer؛ DNA Laddering Assay؛ Thiadiazole Compound
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مراجع
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