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آمار
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Existence of other Cellular Receptors for Edema Factor of Bacillus anthracis is evidenced by Protective Antigen Independent Inhibition of Embryo Growth and Angiogenesis | ||
| Archives of Razi Institute | ||
| مقالات آماده انتشار، پذیرفته شده، انتشار آنلاین از تاریخ 31 شهریور 1400 اصل مقاله (484.32 K) | ||
| نوع مقاله: Original Articles | ||
| شناسه دیجیتال (DOI): 10.22092/ari.2021.355959.1756 | ||
| نویسندگان | ||
R Khandia   1، 2؛ B Pattnaik3؛ K Rajukumar1؛ A. K Pateriya1؛ N Puranik2؛ S Bhatia1؛ H Murugkar1
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| 1ICAR-National Institute for High Security Animal Diseases, Anand Nagar, Bhopal, MP | ||
| 2Department of Biochemistry and Genetics, Barkatullah University, Bhopal, MP | ||
| 3Project Directorate on Foot and Mouth Disease, Indian Council of Agricultural Research, Mukteswar - Kumaon, Nainital, UK | ||
| چکیده | ||
| Edema factor (EF) is one of major secretary protein of anthrax bacterium along with protective antigen (PA) and lethal factor (LF). Edema factor is a calcium and calmodulin dependent adenylyl cyclase, increasing intracellular levels of cAMP. Intracellular trafficking of EF is mediated through PA upon binding with ATR/CMG2 receptors, which are involved in other physiological functions of cells also. cAMP is secondary messenger, known to activate multiple signaling cascades involved in cytokinetics of actin molecules and cell junction formation. In the present study, the effect of EF on growth and angiogenesis pattern was evaluated in chicken embryo in in-ovo model. Reduction in angiogenesis in chorio allantoic membrane (CAM) of chicken embryonated egg and retardation in embryo growth by EF was observed despite the absence of trafficking moiety PA, which is required to transfer the EF molecule inside the cell. Angiogenesis inhibition and embryo growth retardation is suggestive of usage of an alternative receptor by EF to modulate these cellular functions. To support the assumption in-silico, docking was carried out between EF as ligand and Hepatocyte growth factor receptor (cMET) and vascular endothelial growth factor (VEGF) receptors, which are majorly involved in growth and angiogenesis. The analysis revealed a very strong binding of EF with cMET receptor (in terms of number of hydrogen bonds and energy) in comparison to its own ligand hepatocyte growth factor (HGF), indicating use of cMET receptor by EF and causing angiogenesis and embryo growth retardation possibly by competitive inhibition of HGF ligand or receptor mediated endocytosis. | ||
| کلیدواژه‌ها | ||
| angiogenesis inhibition؛ Edema factor؛ CAM؛ embryo growth retardation؛ cAMP؛ signaling molecule | ||
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آمار تعداد مشاهده مقاله: 9 تعداد دریافت فایل اصل مقاله: 14 |
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