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Zhernakova, N. I, Bunova, S. S, Agarkov, N. M, Lebedev, D. T, Aksenov, V. V. (1400). Vitamin D Deficiency as an Independent Predictor of Myocardial Infarction in the Elderly. سامانه مدیریت نشریات علمی, 76(4), 1069-1076. doi: 10.22092/ari.2021.356047.1766
N. I Zhernakova; S. S Bunova; N. M Agarkov; D. T Lebedev; V. V Aksenov. "Vitamin D Deficiency as an Independent Predictor of Myocardial Infarction in the Elderly". سامانه مدیریت نشریات علمی, 76, 4, 1400, 1069-1076. doi: 10.22092/ari.2021.356047.1766
Zhernakova, N. I, Bunova, S. S, Agarkov, N. M, Lebedev, D. T, Aksenov, V. V. (1400). 'Vitamin D Deficiency as an Independent Predictor of Myocardial Infarction in the Elderly', سامانه مدیریت نشریات علمی, 76(4), pp. 1069-1076. doi: 10.22092/ari.2021.356047.1766
Zhernakova, N. I, Bunova, S. S, Agarkov, N. M, Lebedev, D. T, Aksenov, V. V. Vitamin D Deficiency as an Independent Predictor of Myocardial Infarction in the Elderly. سامانه مدیریت نشریات علمی, 1400; 76(4): 1069-1076. doi: 10.22092/ari.2021.356047.1766

Vitamin D Deficiency as an Independent Predictor of Myocardial Infarction in the Elderly

Archives of Razi Institute
مقاله 37، دوره 76، شماره 4، آذر و دی 2021، صفحه 1069-1076    اصل مقاله (395.82 K)
نوع مقاله: Original Articles
شناسه دیجیتال (DOI): 10.22092/ari.2021.356047.1766
نویسندگان
N. I Zhernakova* 1؛ S. S Bunova1؛ N. M Agarkov1، 2؛ D. T Lebedev1؛ V. V Aksenov2
1FGAOU VO, Belgorod State National Research University, Belgorod, Russia
2FGBOU VO, South-West State University, Kursk, Russia
چکیده
Cardiovascular diseases are among the most common causes of disability and death in the world, and the number of patients with this category of diseases is increasing every year. This study aimed to investigate the role of vitamin D and the problems caused by its deficiency on the cardiovascular system. Level of D-(25[OH]D) in blood was studied by enzyme immunoassay in 95 elderly patients with myocardial infarction (MI) (the main group) and 92 elderly patients with no history of MI. The level of lipid metabolism as an indicator was determined using a KoneLab 300 auto-analyzer. Based on the results of this study, it was found that the elderly group without MI had the highest amount of D-(25[OH]D)(24.5±1.2), compared to the elderly group with MI (14.8±1.3). The rates of expressed deficiency, deficiency, and insufficiency in the group of elderly with MI were 53.6±5.1, 23.2±4.4, and 12.6±3.4%, respectively. This experiment has shown that D-(25[OH]D) is involved in lipid metabolism and reduces the accumulation of cholesterol by macrophages. The content of vitamin D in blood plasma was a prognostic predictor of MI, which improved MI in the elderly. Regardless of pathological changes, the deficit level of D-(25[OH]D) should be considered a laboratory predictor of MI in the elderly.
کلیدواژه‌ها
Lipid metabolism؛ Myocardial infarction؛ Old age Prognostic value؛ Vitamin D
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مراجع
  1. Hastings KG, Boothroyd DB, Kapphahn K, Hu J, Rehkopf DH, Cullen MR, et al. Socioeconomic differences in the epidemiologic transition from heart disease to cancer as the leading cause of death in the United States, 2003 to 2015: an observational study. Ann Intern Med. 2018;169(12):836-44.
  2. Huang J, Wang Z, Hu Z, Jiang W, Li B. Association between blood vitamin D and myocardial infarction: A meta-analysis including observational studies. Clinica Chimica Acta. 2017;471:270-5.
  3. Agarkov N, Markelov M, Markelova E, Lutai Y, Volkov P. The information content and predictive value of cardiac markers in myocardial infarction in the elderly. Adv. Gerontol. 2020;33(1):82-6.
  4. Hadaegh F, Harati H, Ghanbarian A, Azizi F. Prevalence of coronary heart disease among Tehran adults: Tehran Lipid and Glucose Study. East Mediterr Health J. 2009;15(1):157-66
  5. Kinosian B, Glick H, Garland G. Cholesterol and coronary heart disease: predicting risks by levels and ratios. Ann Intern Med. 1994;121(9):641-7.
  6. Goldbourt U, Yaari S, Medalie JH. Isolated low HDL cholesterol as a risk factor for coronary heart disease mortality: a 21-year follow-up of 8000 men. Arterioscler Thromb Vasc Biol. 1997;17(1):107-13.
  7. Stamler J, Neaton JD, Wentworth DN. Blood pressure (systolic and diastolic) and risk of fatal coronary heart disease. Hypertension. 1989;13(5):I2.
  8. Fuller J, Shipley M, Rose G, Jarrett RJ, Keen H. Coronary-heart-disease risk and impaired glucose tolerance The Whitehall Study. The Lancet. 1980;315(8183):1373-6.
  9. Welles CC, Whooley MA, Karumanchi SA, Hod T, Thadhani R, Berg AH, et al. Vitamin D deficiency and cardiovascular events in patients with coronary heart disease: data from the Heart and Soul Study. Am J Epidemiol. 2014;179(11):1279-87.
  10. Hayes A, Cashman KD. Food-based solutions for vitamin D deficiency: putting policy into practice and the key role for research. Proc Nutr Soc. 2017;76(1):54-63.
  11. Grimes D, Hindle E, Dyer T. Sunlight, cholesterol and coronary heart disease. QJM: Int J Med. 1996;89(8):579-90.
  12. Achinger SG, Ayus JC. The role of vitamin D in left ventricular hypertrophy and cardiac function. Kidney Int. 2005;67:S37-S42.
  13. Adela R, Borkar RM, Bhandi MM, Vishwakarma G, Reddy PNC, Srinivas R, et al. Lower vitamin D metabolites levels were associated with increased coronary artery diseases in type 2 diabetes patients in India. Sci Rep. 2016;6(1):1-13.
  14. Gotsman I, Shauer A, Zwas DR, Hellman Y, Keren A, Lotan C, et al. Vitamin D deficiency is a predictor of reduced survival in patients with heart failure; vitamin D supplementation improves outcome. Eur J Heart Fail. 2012;14(4):357-66.
  15. Diez ER, Altamirano LB, García IM, Mazzei L, Prado NJ, Fornes MW, et al. Heart remodeling and ischemia–reperfusion arrhythmias linked to myocardial vitamin D receptors deficiency in obstructive nephropathy are reversed by Paricalcitol. J. Cardiovasc Pharmacol Ther. 2015;20(2):211-20.
  16. Nikonenko O, Nikonenko A, Chmul K, Osaulenko V. Algorithm of Differentiated Approach to the Treatment of CHD Patients with Impaired Homocysteine and Vitamin D Metabolism before and after Coronary Artery Bypass Grafting. Ukr J Card Surg. 2020;2 (39):22-8.
  17. Drapkina O, Shepel R, Fomin V, Svistunov A. Place of vitamin D in the prevention of premature aging and the development of age-associated diseases. Ter Arkhiv. 2018;90(1):69-75.
  18. Fiani B, Barthelmass M, Siddiqi I, Kortz M, Pennington E, Pasko K. Vitamin D as a modifiable risk

   factor, predictor, and theoretical therapeutic agent for vasospasm in spontaneous subarachnoid hemorrhage. Acta Neurol Belg. 2021:1-5.

  1. Jorde R, Schirmer H, Wilsgaard T, Joakimsen RM, Mathiesen EB, Njølstad I, et al. Polymorphisms related to the serum 25-hydroxyvitamin D level and risk of myocardial infarction, diabetes, cancer and mortality. The Tromsø Study. PloS one. 2012;7(5):e37295.
  2. Ku Y-C, Liu M-E, Ku C-S, Liu T-Y, Lin S-L. Relationship between vitamin D deficiency and cardiovascular disease. World J Cardiol. 2013;5(9):337.
  3. Milazzo V, De Metrio M, Cosentino N, Marenzi G, Tremoli E. Vitamin D and acute myocardial infarction. World J Cardiol. 2017;9(1):14.
  4. Pittas AG, Chung M, Trikalinos T, Mitri J, Brendel M, Patel K, et al. Systematic review: vitamin D and cardiometabolic outcomes. Ann Intern Med. 2010;152(5):307-14.
  5. Wang TJ, Pencina MJ, Booth SL, Jacques PF, Ingelsson E, Lanier K, et al. Vitamin D deficiency and risk of cardiovascular disease. Circulation. 2008;117(4):503-11.
  6. Meyer HE, Smedshaug GB, Kvaavik E, Falch JA, Tverdal A, Pedersen JI. Can vitamin D supplementation reduce the risk of fracture in the elderly? A randomized controlled trial. J Bone Miner Res. 2002;17(4):709-15.
  7. John WG, Noonan K, Mannan N, Boucher BJ. Hypovitaminosis D is associated with reductions in serum apolipoprotein AI but not with fasting lipids in British Bangladeshis. Am J Clin Nutr. 2005;82(3):517-22.
  8. Płudowski P, Karczmarewicz E, Bayer M, Carter G, Chlebna-Sokół D, Czech-Kowalska J, et al. Practical guidelines for the supplementation of vitamin D and the treatment of deficits in Central Europe—recommended vitamin D intakes in the general population and groups at risk of vitamin D deficiency. Endokrynol Pol. 2013;64(4):319-27.
  9. Hopkins W, Marshall S, Batterham A, Hanin J. Progressive statistics for studies in sports medicine and exercise science. Med Sci Sports Exerc. 2009;41(1):3.
  10. Anderson JL, May HT, Horne BD, Bair TL, Hall NL, Carlquist JF, et al. Relation of vitamin D deficiency to cardiovascular risk factors, disease status, and incident events in a general healthcare population. Am J Cardiol. 2010;106(7):963-8.
  11. Karur S, Veerappa V, Nanjappa MC. Study of vitamin D deficiency prevalence in acute myocardial infarction. IJC Heart Vessel. 2014;3:57-9.
  12. Lee JH, Gadi R, Spertus JA, Tang F, O'Keefe JH. Prevalence of vitamin D deficiency in patients with acute myocardial infarction. Am J Cardiol. 2011;107(11):1636-8.
  13. Artaza JN, Mehrotra R, Norris KC. Vitamin D and the cardiovascular system. Clin J Am Soc Nephrol. 2009;4(9):1515-22.
  14. Kharlamov A, Perrish A, IaL G, Kh R, EIu I. Vitamin D in the treatment of cardiorenal syndrome in patients with chronic nephropathy. Kardiologiia. 2012;52(3):33-44.
  15. Norman P, Powell J. Vitamin D and cardiovascular disease. Circ Res. 2014;114(2):379-93.
  16. Murr C, Pilz S, Grammer TB, Kleber ME, Meinitzer A, Boehm BO, et al. Vitamin D deficiency parallels inflammation and immune activation, the Ludwigshafen Risk and Cardiovascular Health (LURIC) study. Clin Chem Lab Med. 2012;50(12):2205-12.
  17. Ng LL, Sandhu JK, Squire IB, Davies JE, Jones DJ. Vitamin D and prognosis in acute myocardial infarction. Int J Cardiol. 2013;168(3):2341-6.
  1. Giovannucci E, Liu Y, Hollis BW, Rimm EB. 25-hydroxyvitamin D and risk of myocardial infarction in men: a prospective study. Arch Intern Med. 2008;168(11):1174-80.
  2. el Maaty MAA, Gad MZ. Vitamin D deficiency and cardiovascular disease: potential mechanisms and novel perspectives. J Nutr Sci Vitaminol. 2013;59(6):479-88.
  3. Oh J, Weng S, Felton SK, Bhandare S, Riek A, Butler B, et al. 1, 25 (OH) 2 vitamin D inhibits foam cell formation and suppresses macrophage cholesterol uptake in patients with type 2 diabetes mellitus. Circulation. 2009;120(8):687-98.
  4. Papandreou D, Hamid Z-T-N. The role of vitamin D in diabetes and cardiovascular disease: an updated review of the literature. Dis Markers. 2015;2015.
40.          Gannagé-Yared M-H, Chedid R, Khalife S, Azzi E, Zoghbi F, Halaby G. Vitamin D in relation to metabolic risk factors, insulin sensitivity and adiponectin in a young Middle-Eastern population. Eur J Endocrinol. 2009;160(6):965-71.

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