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Jawad, M. A, Kadhim, A. J, Hasan, S. Y. (1400). Histological Study of the Effect of Aqueous Extract of the Beetle Cocoon on Liver Tissue of Male Mice. سامانه مدیریت نشریات علمی, (), -. doi: 10.22092/ari.2021.356080.1773
M. A Jawad; A. J Kadhim; S. Y Hasan. "Histological Study of the Effect of Aqueous Extract of the Beetle Cocoon on Liver Tissue of Male Mice". سامانه مدیریت نشریات علمی, , , 1400, -. doi: 10.22092/ari.2021.356080.1773
Jawad, M. A, Kadhim, A. J, Hasan, S. Y. (1400). 'Histological Study of the Effect of Aqueous Extract of the Beetle Cocoon on Liver Tissue of Male Mice', سامانه مدیریت نشریات علمی, (), pp. -. doi: 10.22092/ari.2021.356080.1773
Jawad, M. A, Kadhim, A. J, Hasan, S. Y. Histological Study of the Effect of Aqueous Extract of the Beetle Cocoon on Liver Tissue of Male Mice. سامانه مدیریت نشریات علمی, 1400; (): -. doi: 10.22092/ari.2021.356080.1773

Histological Study of the Effect of Aqueous Extract of the Beetle Cocoon on Liver Tissue of Male Mice

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مقالات آماده انتشار، پذیرفته شده، انتشار آنلاین از تاریخ 10 مهر 1400  XML اصل مقاله (478.86 K)
نوع مقاله: Short Communication
شناسه دیجیتال (DOI): 10.22092/ari.2021.356080.1773
نویسندگان
M. A Jawad email 1؛ A. J Kadhim1؛ S. Y Hasan2
1Al-Nisour University College, Iraq
2National University For Science And Technology, Iraq
چکیده
The long history of traditionalmedicine in different cultures based on inheritance of experiences, principles, ability and observes, still used nowadays to prevent and/or treatment of diseases worldwide. Among which the extracts used in traditional medicine is aqueous beetle cocoon extract of Larinus maculates popularly known as Tihan in Iraq.To determine the histological effect of this extract on mice liver tissue, the animals were divided into four groups (n = 5) were treated with (150, 200, 400) mg/kg respectively of Cocoon aqueous extract of  Larinus maculatesfor 14 days. Histology and immunohistochemistry test was performed to evaluate changes in liver tissue and TNF-α levels.The results showed dose depended changes, various pathological changes in the liver tissue observed including infiltrations, congestion andvaculation along with some dead cells, necrotichepatocyte were observed in the liver of highly concentrated treatment group. (400 mg kg-1). Also, TNF-α level in the liver tissue increased by increasing the concentration of the extract.Immunohistochemistry result of positive reaction to TNF-α revealed high reaction in the liver tissue of mice treated with 200 mg kg-1 and 400 mg kg-1 compared with control group.The present study showed that changes in hepatocytes and the severity of pathological changes in the liver depends on the concentration of extract of Larinus maculates
کلیدواژه‌ها
Larinus maculates؛ Histological Changes؛ Liver؛ Male Mice
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