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Effects of Structural Manipulation on the Bioactivity of some Coumarin-Based Products | ||
| Archives of Razi Institute | ||
| مقالات آماده انتشار، پذیرفته شده، انتشار آنلاین از تاریخ 12 مهر 1400 اصل مقاله (644.13 K) | ||
| نوع مقاله: Original Articles | ||
| شناسه دیجیتال (DOI): 10.22092/ari.2021.356100.1776 | ||
| نویسندگان | ||
Y Fakri Mustafa  ؛ R Riyadh Khalil؛ E Tareq Mohammed؛ M. K Bashir؛ M Khudhayer Oglah
| ||
| Department of Pharmaceutical Chemistry, College of Pharmacy, University of Mosul, Mosul, Iraq | ||
| چکیده | ||
| Coumarin (2H-1-benzopyran-2-one) is a plant-derived natural product known for its pharmacological properties such as anti-inflammatory, anticoagulant, antibacterial, antifungal, antiviral, anticancer, antihypertensive, antitubercular, anticonvulsant, antiadipogenic, antihyperglycemic, antioxidant, and neuroprotective. Two coumarin-based products were identified in the seeds of two apple phenotypes commonly known as Granny Smith and Red Delicious. The aim of the current study was to evaluate chemically manipulation of these coumarin based products to more lipophilic semisynthetic compounds and to trace the role of the phenolic hydroxyl group in the bioactivity of the parent natural products. The bioactivity evaluation included studying the potentials of the natural- and semisynthetic-coumarins as antioxidant, antineoplastic, antifungal, and antibacterial agents. At the first step the antiradical potential of these products was evaluated versus the free radicals of hydroxyl and DPPH. The second potential was investigated utilizing an MTT-based photo assay versus several cancer-line cells, included SK-OV-3, MCF-7, KYSE-30, LC540, HeLa, AR42J, AB12, and AMN3. The third and fourth potentials were recognized by conducting a disc-diffusion method against six infective bacterial strains and three fungal strains. The test bacteria wereShigella dysenteriae, Klebsiella pneumonia, Escherichia coli, Haemophilus influenzae, Salmonella typhi, and Pseudomonas aeruginosa. While the test fungi were Aspergillus flavus, Candida albicans, and Aspergillus niger. The results arising from these biopotentials revealed that the investigated functional group exerted a positive impact on the antiradical and antineoplastic potentials of the natural derivatives, but a negative consequence on their antimicrobial potentials. | ||
| کلیدواژه‌ها | ||
| Natural coumarins؛ Semisynthetic derivatives؛ Antiradical؛ Antineoplastic؛ Antibacterial؛ Antifungal؛ Structural manipulation | ||
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آمار تعداد مشاهده مقاله: 17 تعداد دریافت فایل اصل مقاله: 6 |
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