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Investigation on the Cytotoxic Activity of Alcoholic Extract of Eucalyptus camaldulensis on Breast Cancer Cell Line | ||
| Archives of Razi Institute | ||
| مقالات آماده انتشار، پذیرفته شده، انتشار آنلاین از تاریخ 12 مهر 1400 اصل مقاله (581.57 K) | ||
| نوع مقاله: Original Articles | ||
| شناسه دیجیتال (DOI): 10.22092/ari.2021.356104.1778 | ||
| نویسندگان | ||
W. H Mohammed  ؛ S. A Soud؛ A. H Hameed؛ N. N Hussein
| ||
| Division of Biotechnology, Department of Applied Sciences, University of Technology, Baghdad, Iraq | ||
| چکیده | ||
| The spread of different types of cancer has been increasing in the recent centry. The use of chemical drugs, in addition to the development of drug resistance, also cause serious side effects. Eucalyptus camaldulensis (E. camaldulensis) is one of the most famous herbal remedies considered owing to its anti-inflammatory and boosting the intimate immune system, and has some anti-proliferative effects on cancerous cell lines. In the current study the cytotoxic activity of alcoholic extract of Eucalyptus camaldulensis (E. camaldulensis) at different concentrations 6.125, 12.5, 25, 50 and 100 µg/mL was investigated on breast cancer cell line MCF-7. To study the antioxidant efficieny of ethanolic extract of Eucalyptus camaldulensis, 2,2-diphenyl-1-picryl-hydrazyl-hydrate (DPPH) and 2,2'-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid (ABTS)) analysis were used. By FTIR analysis and Phytochemical screening, the results showed many active compounds found in this extract like Tannins, Saponins, Phenolic compounds, Reducing sugar, Terpenoids, Steroids, Glucosides, Alkaloids and Flavonoids. Also the results were demonstrated that this extract significantly inhibited the growth of MCF-7 cell line in a concentration dependent manner in comparions to the control, and the cytotoxic activity of this extract increase with the increase of the concentration. The results indicate that E. camaldulensis can be considered as a particularly valuable source of effective anti-proliferative and cytotoxic agents. The experimental findings demonstrated that E. camaldulensis extract possessed significant antioxidant efficiency and anti-proliferative effects on cancerous cell lines. | ||
| کلیدواژه‌ها | ||
| Antioxidant؛ Anti-proliferative؛ Breast cancer؛ Crud extract؛ Ethanol | ||
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آمار تعداد مشاهده مقاله: 8 تعداد دریافت فایل اصل مقاله: 2 |
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