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آمار
| تعداد نشریات | 278 |
| تعداد نشریات سازمان | 77 |
| تعداد شماره‌ها | 2,193 |
| تعداد مقالات | 25,444 |
| تعداد مشاهده مقاله | 13,749,819 |
| تعداد دریافت فایل اصل مقاله | 11,019,939 |
Clinical Applications of Substance P (Neurokinin-1 Receptor) Antagonist in Canine Medicine | ||
| Archives of Razi Institute | ||
| مقالات آماده انتشار، پذیرفته شده، انتشار آنلاین از تاریخ 17 مهر 1400 اصل مقاله (558.69 K) | ||
| نوع مقاله: Mini Review | ||
| شناسه دیجیتال (DOI): 10.22092/ari.2021.356171.1797 | ||
| نویسندگان | ||
K Sharun   1؛ K Jambagi2؛ M Arya1؛ - Aakanksha1؛ S. N Chaithra1؛ P. K Patel2؛ S. K Dixit2؛ K Dhama3
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| 1Division of Surgery, ICAR-Indian Veterinary Research Institute, Izatnagar, Bareilly, Uttar Pradesh-243122, India | ||
| 2Division of Medicine, ICAR-Indian Veterinary Research Institute, Izatnagar, Bareilly, Uttar Pradesh-243122, India | ||
| 3Division of Pathology, ICAR-Indian Veterinary Research Institute, Izatnagar, Bareilly, Uttar Pradesh-243122, India | ||
| چکیده | ||
| Substance P binds to the Neurokinin-1 (NK-1) receptors found in the emetic center of the CNS to induce emesis. Maropitant is a selective NK-1 receptor antagonist that inhibits the binding of Substance P to NK-1 receptors. It is commonly used for the prevention and treatment of vomiting in dogs. This review aims to discuss and analyze the therapeutic potential of Substance P (Neurokinin-1 receptor) antagonist with a particular focus on the drug maropitant in canine medicine. A systematic literature review was performed to identify literature during the past 20 years (2001-2021) using databases, such as ScienceDirect, PubMed, Scopus, and Google Scholar. The initial search identified 173 articles. Based on the specific inclusion and exclusion criteria, 41 articles were selected for further analysis. Studies have already confirmed the role of Substance P and NK-1 receptors in central pain processing, intestinal smooth muscle contraction, vasodilation, and neurogenic inflammation. Maropitant is considered one of the most effective veterinary antiemetic drugs that are currently in use. It works well against peripheral and central stimuli that trigger the vomiting center. It has already demonstrated therapeutic efficacy in dogs for managing acute vomiting associated with pancreatitis, gastritis, and parvoviral enteritis. It can also prevent and treat chemotherapy-induced emesis and can delay the signs of nausea and adverse gastrointestinal effects. Since maropitant has broad-spectrum antiemetic activity, they can be recommended for managing uremic vomiting in dogs. In addition, it has also exhibited an anesthetic sparing effect since the dogs treated with maropitant require a slightly lower percent of isoflurane as an inhalational anesthetic. NK-1 receptors are also identified in different areas of the pain pathways. Therefore, NK-1 receptor antagonists might be effective for managing visceral pain. However, further studies are required to establish the broad therapeutic potential of NK-1 receptor antagonist drugs such as maropitant in canine medicine. The pain associated with the subcutaneous administration of maropitant is due to metacresol, a preservative used in some formulations. Therefore, the side effects can be eliminated by developing novel maropitant formulations specifically for dogs. | ||
| کلیدواژه‌ها | ||
| Neurokinin-1 receptor antagonist؛ maropitant؛ renal failure؛ antiemetic؛ canine medicine | ||
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آمار تعداد مشاهده مقاله: 14 تعداد دریافت فایل اصل مقاله: 2 |
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