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Falah Alshimerry, A, Ghalib Farhood, R, Hasan Shakir, H. (1400). Role of Toll-Like Receptor 5 in the Development of Ulcerative Colitis. سامانه مدیریت نشریات علمی, 76(6), 1639-1643. doi: 10.22092/ari.2021.356358.1825
A Falah Alshimerry; R Ghalib Farhood; H Hasan Shakir. "Role of Toll-Like Receptor 5 in the Development of Ulcerative Colitis". سامانه مدیریت نشریات علمی, 76, 6, 1400, 1639-1643. doi: 10.22092/ari.2021.356358.1825
Falah Alshimerry, A, Ghalib Farhood, R, Hasan Shakir, H. (1400). 'Role of Toll-Like Receptor 5 in the Development of Ulcerative Colitis', سامانه مدیریت نشریات علمی, 76(6), pp. 1639-1643. doi: 10.22092/ari.2021.356358.1825
Falah Alshimerry, A, Ghalib Farhood, R, Hasan Shakir, H. Role of Toll-Like Receptor 5 in the Development of Ulcerative Colitis. سامانه مدیریت نشریات علمی, 1400; 76(6): 1639-1643. doi: 10.22092/ari.2021.356358.1825

Role of Toll-Like Receptor 5 in the Development of Ulcerative Colitis

Archives of Razi Institute
مقاله 8، دوره 76، شماره 6، بهمن و اسفند 2021، صفحه 1639-1643    اصل مقاله (519.36 K)
نوع مقاله: Original Articles
شناسه دیجیتال (DOI): 10.22092/ari.2021.356358.1825
نویسندگان
A Falah Alshimerry* 1؛ R Ghalib Farhood1؛ H Hasan Shakir2
1Department of Pathology, College of Medicine, University of Babylon, Babylon, Iraq
2Al-Noor Pediatric Hospital, Babil Health Directorate, Republic of Iraqi Ministry of Health, Babylon, Iraq
چکیده
Inflammatory bowel disease (ulcerative colitis and Crohn’s disease) is a remitting and relapsing disease that affects millions of people worldwide. In the intestine, homeostasis between repair and signaling of the proinflammatory of the immune system is needful for the upkeep of intestinal balance. The recent evidence has highlighted the dysfunction of the immune system, particularly toll-like receptors (TLRs)-mediated immune system dysfunction, in the ulcerative colitis pathogenesis. The main objective of the current study was to analyze the expression level of TLR5 at the mRNA in ulcerative colitis patients and investigate the impacts of the TLR5 gene as genetic factors that contribute to the development of ulcerative colitis. The paraffin-embedded blocks were retrospectively collected from 25 patients diagnosed with ulcerative colitis and 25 cases with normal colonic tissue. The quantitative real-time polymerase chain reaction method was employed for the estimation of TLR5at the mRNA level. The analysis of the data of TLR5 gene expression revealed that the expression of this gene is downregulated in ulcerative colitis cases, as compared to that in normal colonic tissue. As evidenced by the results of this study, TLR5 may play a role in the development of ulcerative colitis; therefore, it should be introduced in the management of ulcerative colitis.
کلیدواژه‌ها
TLR5؛ Ulcerative Colitis؛ Bowel disease
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مراجع
  1. Molodecky NA, Soon S, Rabi DM, Ghali WA, Ferris M, Chernoff G, et al. Increasing incidence and prevalence of the inflammatory bowel diseases with time, based on systematic review. Gastroenterology. 2012;142(1):46-54.42.
  2. Mamoori A, Wahab R, Islam F, Lee K, Vider J, Lu C-T, et al. Clinical and biological significance of miR-193a-3p targeted KRAS in colorectal cancer pathogenesis. Human pathology. 2018;71:145-56.
  3. Baumgart DC, Carding SR. Inflammatory bowel disease: cause and immunobiology. Lancet. 2007;369(9573):1627-40.
  4. Geremia A, Biancheri P, Allan P, Corazza GR, Di Sabatino A. Innate and adaptive immunity in inflammatory bowel disease. Autoimmun Rev. 2014;13(1):3-10.
  5. Roggenbuck D, Reinhold D, Baumgart DC, Schierack P, Conrad K, Laass MW. Autoimmunity in Crohn's disease—a putative stratification factor of the clinical phenotype. Adv Clin Chem. 2016;77:77-101.
  6. Halmos EP, Gibson PR. Dietary management of IBD—insights and advice. Nat Rev Gastroenterol. Hepatol. 2015;12(3):133-46.
  7. Connelly TM, Berg AS, Harris III L, Brinton D, Deiling S, Koltun WA. Genetic determinants associated with early age of diagnosis of IBD. Dis Colon Rectum. 2015;58(3):321-7.
  8. O’Toole A, Korzenik J. Environmental triggers for IBD. Curr Gastroenterol Rep. 2014;16(7):396.
  9. Zhang Y-Z, Li Y-Y. Inflammatory bowel disease: pathogenesis. World J Gastroenterol. 2014;20(1):91.
  10. Zhang D, Zhang G, Hayden MS, Greenblatt MB, Bussey C, Flavell RA, et al. A toll-like receptor that prevents infection by uropathogenic bacteria. Science. 2004;303(5663):1522-6.
  11. Takeda K, Akira S. Toll-like receptors in innate immunity. Int Immunol. 2005;17(1):1-14.
  12. Himmel ME, Hardenberg G, Piccirillo CA, Steiner TS, Levings MK. The role of T‐regulatory cells and Toll‐like receptors in the pathogenesis of human inflammatory bowel disease. Immunology. 2008;125(2):145-53.
  13. Reid G, Howard J, Gan BS. Can bacterial interference prevent infection? Trends Microbiol. 2001;9(9):424-8.
  1. Rhee SH, Hwang D. Murine TOLL-like receptor 4 confers lipopolysaccharide responsiveness as determined by activation of NFκB and expression of the inducible cyclooxygenase. J Biol Chem. 2000;275(44):34035-40.
  2. Rhee SH, Jones BW, Toshchakov V, Vogel SN, Fenton MJ. Toll-like receptors 2 and 4 activate STAT1 serine phosphorylation by distinct mechanisms in macrophages. J Biol Chem. 2003;278(25):22506-12.
  3. Takeda K, Kaisho T, Akira S. Toll-like receptors. Annu Rev Immunol. 2003;21(1):335-76.
  4. Cario E, Podolsky DK. Differential alteration in intestinal epithelial cell expression of toll-like receptor 3 (TLR3) and TLR4 in inflammatory bowel disease. Infect Immun. 2000;68(12):7010-7.
  1. Lodes MJ, Cong Y, Elson CO, Mohamath R, Landers CJ, Targan SR, et al. Bacterial flagellin is a dominant antigen in Crohn disease. J Clin Investig. 2004;113(9):1296-306.
  2. Rhee SH, Im E, Riegler M, Kokkotou E, O'brien M, Pothoulakis C. Pathophysiological role of Toll-like receptor 5 engagement by bacterial flagellin in colonic inflammation. PNAS. 2005;102(38):13610-5.
  3. Stanislawowski M, Wierzbicki P, Golab A, Adrych K, Kartanowicz D, Wypych J, et al. Decreased Toll-like receptor-5 (TLR-5) expression in the mucosa of ulcerative colitis patients. J Physiol Pharmacol. 2009;60(Suppl 4):71-5.
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