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Falah Alshimerry, A, Ghalib Farhood, R, Hasan Shakir, H. (1400). The Role of TLR5 in the Development of Ulcerative Colitis. سامانه مدیریت نشریات علمی, (), -. doi: 10.22092/ari.2021.356358.1825
A Falah Alshimerry; R Ghalib Farhood; H Hasan Shakir. "The Role of TLR5 in the Development of Ulcerative Colitis". سامانه مدیریت نشریات علمی, , , 1400, -. doi: 10.22092/ari.2021.356358.1825
Falah Alshimerry, A, Ghalib Farhood, R, Hasan Shakir, H. (1400). 'The Role of TLR5 in the Development of Ulcerative Colitis', سامانه مدیریت نشریات علمی, (), pp. -. doi: 10.22092/ari.2021.356358.1825
Falah Alshimerry, A, Ghalib Farhood, R, Hasan Shakir, H. The Role of TLR5 in the Development of Ulcerative Colitis. سامانه مدیریت نشریات علمی, 1400; (): -. doi: 10.22092/ari.2021.356358.1825

The Role of TLR5 in the Development of Ulcerative Colitis

Archives of Razi Institute
مقالات آماده انتشار، پذیرفته شده، انتشار آنلاین از تاریخ 29 مهر 1400  XML اصل مقاله (290.9 K)
نوع مقاله: Original Articles
شناسه دیجیتال (DOI): 10.22092/ari.2021.356358.1825
نویسندگان
A Falah Alshimerry email 1؛ R Ghalib Farhood1؛ H Hasan Shakir2
1Department of Pathology, College of Medicine, University of Babylon, Babylon, Iraq
2Al-Noor Hospital for Children, Babil Health Directorate, Republic of Iraqi Ministry of Health, Babylon, Iraq
چکیده
Inflammatory bowel disease (ulcerative colitis and Crohn’s disease) is one remitting and relapsing disease that affects millions of people worldwide. In the intestine, a homostasis between repair and signaling of the proinflammatory of the immune system is needful for the upkeep of intestinal balance. The recent evidence has highlighted the dysfunction of immune system, particularly toll-like receptors (TLRs)-mediated immune system dysfunction, as vital role in the ulcerative colitis pathogenesis. The main objective of the current study was to analyze the expression level of TLR5 at the mRNA in the ulcerative colitis (UC) patients and investigation on the impacts of TLR5 gene as genetic factors that contribute to development of UC. The paraffin-embedded blocks retrospectively collected from 25 patients diagnosed with ulcerative colitis and 25 cases of normal colonic tissue. Quantitative real-time PCR method employed for estimation of TLR5at the mRNA level. Analysis of the data of TLR5 gene expression revealed that the expression of this gene were found to be down regulated in ulcerative colitis cases in relation to normal colonic tissue. The results of this study were showed that TLR5 may have a role in the development of ulcerative colitis and could introduce in plans of ulcerative colitis management.
کلیدواژه‌ها
TLR5؛ Ulcerative Colitis؛ bowel disease
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