اخبار و اعلانات

 آمار

تعداد نشریات283
تعداد نشریات سازمان81
تعداد شماره‌ها2,726
تعداد مقالات31,041
تعداد مشاهده مقاله27,865,196
تعداد دریافت فایل اصل مقاله16,231,964
Hamza Fares, B, Abdul Hussain Al-tememy, H, Mohammed Baqir Al-Dhalimy, A. (1400). Evaluation of the Toxic Effects of Aluminum Hydroxide Nanoparticles as Adjuvants in Vaccinated Neonatal Mice. سامانه مدیریت نشریات علمی, 77(1), 221-228. doi: 10.22092/ari.2021.356418.1839
B Hamza Fares; H Abdul Hussain Al-tememy; A Mohammed Baqir Al-Dhalimy. "Evaluation of the Toxic Effects of Aluminum Hydroxide Nanoparticles as Adjuvants in Vaccinated Neonatal Mice". سامانه مدیریت نشریات علمی, 77, 1, 1400, 221-228. doi: 10.22092/ari.2021.356418.1839
Hamza Fares, B, Abdul Hussain Al-tememy, H, Mohammed Baqir Al-Dhalimy, A. (1400). 'Evaluation of the Toxic Effects of Aluminum Hydroxide Nanoparticles as Adjuvants in Vaccinated Neonatal Mice', سامانه مدیریت نشریات علمی, 77(1), pp. 221-228. doi: 10.22092/ari.2021.356418.1839
Hamza Fares, B, Abdul Hussain Al-tememy, H, Mohammed Baqir Al-Dhalimy, A. Evaluation of the Toxic Effects of Aluminum Hydroxide Nanoparticles as Adjuvants in Vaccinated Neonatal Mice. سامانه مدیریت نشریات علمی, 1400; 77(1): 221-228. doi: 10.22092/ari.2021.356418.1839

Evaluation of the Toxic Effects of Aluminum Hydroxide Nanoparticles as Adjuvants in Vaccinated Neonatal Mice

Archives of Razi Institute
مقاله 30، دوره 77، شماره 1، فروردین و اردیبهشت 2022، صفحه 221-228    اصل مقاله (764.31 K)
نوع مقاله: Original Articles
شناسه دیجیتال (DOI): 10.22092/ari.2021.356418.1839
نویسندگان
B Hamza Fares* 1؛ H Abdul Hussain Al-tememy2؛ A Mohammed Baqir Al-Dhalimy3
1Department of Pathology, Faculty of Veterinary Medicine, University of Kufa, Kufa, Iraq
2Department of Poultry Diseases, Veterinary Hospital, Najaf, Iraq
3Altoosi University College, Najaf, Iraq
چکیده
Aluminum hydroxide nanoparticles have been employed in many industries, which are widely abundant in many aspects of human life. The role of the aluminum hydroxide nanoparticles adjuvant is to enhance the immune response. However, the impact of nanoparticles exposure has not been perfectly investigated yet. Accordingly, some questions have been raised about their potentially harmful effects, based on which the current research aims to answer them. This study aimed to investigate the histological effects of aluminum hydroxide nanoparticles and bulk-aluminum hydroxide (bulk Al[OH]3) on the liver, lung, heart, and kidney tissues. For this reason, an experiment was implemented on the aluminum hydroxide nanoparticles adjuvant in five neonatal mice. Intramuscularly, the mice were injected with 0.125 mL of adjuvanted vaccine, while five neonatal mice were injected with bulk and nanoparticles of Al (OH)3 and then sacrificed after one and two months, respectively. Vaccines were controlled by evaluating the histopathological response in neonatal mice. Subsequently, the pathological effect of both adjuvants was surveyed using the histological study of the lung, liver, heart, and kidney of the animals. The obtained recorded data indicated that both types of vaccine adjuvants caused pathological lesions on the histology sections of the liver, lung, heart, and kidney tissues. Moreover, bulk Al (OH)3 adjuvant vaccine was more effective and had a higher pathological response than aluminum hydroxide nanoparticles adjuvant vaccine. In addition, the total DNA content in both groups was estimated using Fluorometer from Promega. Compared to aluminum hydroxide nanoparticles groups, the tissues indicated a decrease in total DNA content obtained in bulk Al (OH)3 groups. Therefore, it can be concluded that the exposure to aluminum hydroxide nanoparticles would result in less pronounced toxicity, as well as systemic inflammation, compared to the bulk Al (OH)3 aluminum hydroxide.
کلیدواژه‌ها
Al (OH)3NPs؛ Histopathology؛ Mice
سایر فایل های مرتبط با مقاله
مراجع
  1. Oberdörster G, Oberdörster E, Oberdörster J. Nanotoxicology: an emerging discipline evolving from studies of ultrafine particles. Environ Health Perspect. 2005;113(7):823-39.
  2. Dağlıoğlu Y, Yılmaz Öztürk B. Effect of concentration and exposure time of ZnO-TiO2 nanocomposite on photosynthetic pigment contents, ROS production ability, and bioaccumulation of freshwater algae (Desmodesmus multivariabilis). Caryologia. 2018;71(1):13-23.
  3. Zhang Y, Bai Y, Jia J, Gao N, Li Y, Zhang R, et al. Perturbation of physiological systems by nanoparticles. Chem Soc Rev. 2014;43(10):3762-809.
  4. Schinwald A, Murphy FA, Jones A, MacNee W, Donaldson K. Graphene-based nanoplatelets: a new risk to the respiratory system as a consequence of their unusual aerodynamic properties. ACS nano. 2012;6(1):736-46.
  5. Bai Y, Zhang Y, Zhang J, Mu Q, Zhang W, Butch ER, et al. Repeated administrations of carbon nanotubes in male mice cause reversible testis damage without affecting fertility. Nat Nanotechnol. 2010;5(9):683-9.
  6. Zhang L, Gu F, Chan J, Wang A, Langer R, Farokhzad O. Nanoparticles in medicine: therapeutic applications and developments. Clin Pharmacol Ther. 2008;83(5):761-9.
  7. Park E-J, Kim H, Kim Y, Choi K. Repeated-dose toxicity attributed to aluminum nanoparticles following 28-day oral administration, particularly on gene expression in mouse brain. Toxicol Environ Chem. 2011;93(1):120-33.
  8. Bancroft JD, Gamble M. Theory and practice of histological techniques: Elsevier health sciences; 2008.
  9. Confavreux C, Suissa S, Saddier P, Bourdès V, Vukusic S. Vaccinations and the risk of relapse in multiple sclerosis. N Engl J Med. 2001;344(5):319-26.
  10. Gupta RK, Rost BE, Relyveld E, Siber GR. Adjuvant properties of aluminum and calcium compounds. Vaccine design. 1995:229-48.
  11. Abdelhalim MAK, Jarrar BM. Histological alterations in the liver of rats induced by different gold nanoparticle sizes, doses and exposure duration. J Nanobiotechnology. 2012;10(1):1-9.
  12. Abdelhalim MAK, Jarrar BM. Gold nanoparticles induced cloudy swelling to hydropic degeneration, cytoplasmic hyaline vacuolation, polymorphism, binucleation, karyopyknosis, karyolysis, karyorrhexis and necrosis in the liver. Lipids Health Dis. 2011;10(1):1-6.
  13. Segerer S, Nelson PJ, SCHLÖNDORFF D. Chemokines, chemokine receptors, and renal disease: from basic science to pathophysiologic and therapeutic studies. J Am Soc Nephrol. 2000;11(1):152-76.
  14. Muddana HS, Morgan TT, Adair JH, Butler PJ. Photophysics of Cy3-encapsulated calcium phosphate nanoparticles. Nano Lett. 2009;9(4):1559-66.
  15. Oberdörster E. Manufactured nanomaterials (fullerenes, C60) induce oxidative stress in the brain of juvenile largemouth bass. Environ Health Perspect. 2004;112(10):1058-62.
  16. Hillyer JF, Albrecht RM. Gastrointestinal persorption and tissue distribution of differently sized colloidal gold nanoparticles. J Pharm Sci. 2001;90(12):1927-36.
  17. Cui Y, Liu H, Zhou M, Duan Y, Li N, Gong X, et al. Signaling pathway of inflammatory responses in the mouse liver caused by TiO2 nanoparticles. J Biomed Mater Res A. 2011;96(1):221-9.
  18. Babele PK. Zinc oxide nanoparticles impose metabolic toxicity by de-regulating proteome and metabolome in Saccharomyces cerevisiae. Toxicol Rep. 2019;6:64-73.
  1. Li S-Q, Zhu R-R, Zhu H, Xue M, Sun X-Y, Yao S-D, et al. Nanotoxicity of TiO2 nanoparticles to erythrocyte in vitro. Food Chem Toxicol. 2008;46(12):3626-31.
  2. Klotz LO, Sies H. Cellular Generation of Oxidants: Relation to Oxidative Stress. 2009. p. 45-61.
  3. Hou L, Xie K, Qin M, Peng D, Ma S, Shang L, et al. Effects of reactive oxygen species scavenger on the protective action of 100% oxygen treatment against sterile inflammation in mice. Shock. 2010;33(6):646-54.
  4. Patil US, Adireddy S, Jaiswal A, Mandava S, Lee BR, Chrisey DB. In vitro/in vivo toxicity evaluation and quantification of iron oxide nanoparticles. Int J Mol Sci. 2015;16(10):24417-50.
  1. Bustani GS, Baiee FH. Semen extenders: An evaluative overview of preservative mechanisms of semen and semen extenders. Vet World. 2021;14(5):1220.
  2. Baiee F, Al-Wahab BA, Almusawi AA, Yu LL, Fitri W-N, Haron AW, et al. Effect of vitrification on spermatozoa quality in bull semen. EurAsian J Biosci. 2020;14(2).
  3. Love SA, Maurer-Jones MA, Thompson JW, Lin Y-S, Haynes CL. Assessing nanoparticle toxicity. Annu Rev Anal Chem. 2012;5:181-205.
  4. Almansour MI, Alferah MA, Shraideh ZA, Jarrar BM. Zinc oxide nanoparticles hepatotoxicity: histological and histochemical study. Environ Toxicol Pharmacol. 2017;51:124-30.
  5. Mansouri E, Khorsandi L, Orazizadeh M, Jozi Z. Dose-dependent hepatotoxicity effects of Zinc oxide nanoparticles. Nanomed J. 2015;2(4):273-82.
آمار
تعداد مشاهده مقاله: 913
تعداد دریافت فایل اصل مقاله: 415


counter
سامانه مدیریت نشریات علمی. قدرت گرفته از سیناوب