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Ali Abdulla, A, Abdulaali Abed, T, Razzaq Abdul-Ameer, W. (1400). Impact of IL-21 Gene Polymorphisms (rs2055979) and the Levels of Serum IL-21 on the Risk of Multiple Sclerosis. سامانه مدیریت نشریات علمی, 77(1), 81-86. doi: 10.22092/ari.2021.356470.1848
A Ali Abdulla; T Abdulaali Abed; W Razzaq Abdul-Ameer. "Impact of IL-21 Gene Polymorphisms (rs2055979) and the Levels of Serum IL-21 on the Risk of Multiple Sclerosis". سامانه مدیریت نشریات علمی, 77, 1, 1400, 81-86. doi: 10.22092/ari.2021.356470.1848
Ali Abdulla, A, Abdulaali Abed, T, Razzaq Abdul-Ameer, W. (1400). 'Impact of IL-21 Gene Polymorphisms (rs2055979) and the Levels of Serum IL-21 on the Risk of Multiple Sclerosis', سامانه مدیریت نشریات علمی, 77(1), pp. 81-86. doi: 10.22092/ari.2021.356470.1848
Ali Abdulla, A, Abdulaali Abed, T, Razzaq Abdul-Ameer, W. Impact of IL-21 Gene Polymorphisms (rs2055979) and the Levels of Serum IL-21 on the Risk of Multiple Sclerosis. سامانه مدیریت نشریات علمی, 1400; 77(1): 81-86. doi: 10.22092/ari.2021.356470.1848

Impact of IL-21 Gene Polymorphisms (rs2055979) and the Levels of Serum IL-21 on the Risk of Multiple Sclerosis

Archives of Razi Institute
مقاله 12، دوره 77، شماره 1، فروردین و اردیبهشت 2022، صفحه 81-86    اصل مقاله (364.5 K)
نوع مقاله: Original Articles
شناسه دیجیتال (DOI): 10.22092/ari.2021.356470.1848
نویسندگان
A Ali Abdulla* 1؛ T Abdulaali Abed1؛ W Razzaq Abdul-Ameer2
1Department of Biology, College of Sciences, University of Babylon, Babylon, Iraq
2Department of Medicine, Neurology, College of Medicine, University of Babylon, Babylon, Iraq
چکیده
Multiple sclerosis (MS) is a chronic autoimmune disorder of the central nervous system. Genetic and environmental factors have important roles in the induction, onset, and progression of MS. In this study, the IL-21 genotype (rs2055979) (G/T) in Iraqi MS patients was compared with a healthy control group to investigate the possible association of any particular genotype or allele with multiple sclerosis. This study included 70 patients with relapsing-remitting MS and 50 healthy individuals as control. Following the extraction of genomic DNA, polymerase chain reaction-restriction fragment length polymorphism, the frequencies of genotypes, and alleles were calculated and statistically analyzed. The results of the study revealed a significant reduction in the distribution of the wild homozygous genotype (GG) in MS patients, in comparison to a healthy control group (14.3% vs. 34 %; 0.0129 at P≤0.05; odds ratio [OR] 3.0909, 95% confidence interval [CI]: 1.2704-7.5203). However, MS cases and controls did not differ significantly in neither GT nor TT genotypes, 62.9% (OR 0.6402, 95% CI: 0.3064-1.3374) and 52% (OR 0.5494, 95% CI: 0.2074-1.4557), respectively. The data of allele frequencies in patients and controls showed that the G allele frequencies were 0.46 vs. 0.60 in patients and controls, respectively, while T allele frequencies were 0.54 vs. 0.40 in patients and controls, respectively. The current conclusions indicated that in the study group, the GG genotype of IL-21(rs2055979) could be related to MS.
کلیدواژه‌ها
IL-21؛ rs2055979؛ Multiple sclerosis؛ PCR-RFLP
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