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| تعداد نشریات | 279 |
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Effect of Long- Term Treatment with Dexamethasone on liver and kidney histopathology and blood biochemistry in Male Rabbits Lepus cuniculus | ||
| Archives of Razi Institute | ||
| مقالات آماده انتشار، پذیرفته شده، انتشار آنلاین از تاریخ 18 آبان 1400 | ||
| نوع مقاله: Original Articles | ||
| شناسه دیجیتال (DOI): 10.22092/ari.2021.356468.1847 | ||
| نویسندگان | ||
Nawfal Hammadi Jasim  1؛ Dhuha Adel Kareem2؛ Majdy F. Majeed AL Ali2؛ Basil A. Abbas3
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| 1Department of physiology and pharmacology and chemistry, College of Veterinary Medicine, University of Basrah, Iraq | ||
| 2Department of Anatomy and Histology, College of Veterinary Medicine, University of Basrah, Iraq | ||
| 3Department of microbiology and parasitology, College of Veterinary Medicine, University of Basrah, Iraq | ||
| چکیده | ||
| Glucocorticoids have a wide range of pharmacological activity. Generally speaking, the steroid drugs like dexamethasone (DEX) can have severe side effects on the histology of the different organs. In fact, glucocorticoids have been known as powerful medicines which can cure inflammation and work with immune system to treat wide range of health problems. Therefore, the aim of this study was to investigate the effects of DEX on the histological changes of liver and kidney, and blood biochemical parameters. 13 specific pathogen – free male Lepus cuniculus rabbits aged 8-10 months old, with average weight of 1.12 ± 0.13 kg were randomly divided into three groups as follows: Group 1 (n=3) rabbits did not received DEX, they only received saline solution as a placebo (control); Group II (n=5) the animals received 0.25 mg DEX/Kg Body Weight/Day for a period of 56 days; and Group III (n=5) the animals in this group received 0.5 mg DEX/Kg Body Weight/Day for a period of 56 days. Blood was aspirated from the rabbit's marginal ear vein. All blood samples were centrifuged at 3000×g for 10 min to separate serum samples. Blood lipids and trace elements, Zn+2, Cu+2, Ca+2 and Fe+2, were measured. The microscopically analyses of liver and kidneys tissue were performed through the observation of the histological changes in the tissues. The results showed significant (P≤0.05) decrease in the body and organs weight, serum concentrations for the trace elements, on the other hand lipids profile showed significant increase (P≤0.05) for cholesterol, triglycerides, LDL, while a significant decrease was recorded for HDL in both treated groups with DEX compare with control group. The results of histological evaluation showed some degrees of degeneration, necrosis, cells vacuolation and lymphocytes infiltration in kidney and liver tissues in the treatment groups. | ||
| کلیدواژه‌ها | ||
| Dexamethasone؛ Histology؛ Essential Mineral And Lipid Profile | ||
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آمار تعداد مشاهده مقاله: 25 |
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