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The significance of lipid profile parameters in predicting pre-diabetes | ||
| Archives of Razi Institute | ||
| مقالات آماده انتشار، پذیرفته شده، انتشار آنلاین از تاریخ 18 آبان 1400 | ||
| نوع مقاله: Original Articles | ||
| شناسه دیجیتال (DOI): 10.22092/ari.2021.356465.1846 | ||
| نویسندگان | ||
Ola H. Jasim  1؛ Majdi M. Mahmood2؛ A H Ad'hiah3
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| 11 Department of Biology, College of Science, Mustansiriyah University, Baghdad, Iraq | ||
| 2Department of Biology, College of Science, Mustansiriyah University, Baghdad, Iraq | ||
| 3Tropical-Biological Research Unit, College of Science, University of Baghdad, Iraq | ||
| چکیده | ||
| In prediabetes, blood glucose levels are higher than usual but remain below the diabetes threshold. Research into biomarkers for this disease pave a way for controlling diabetes mellitus (DM) or reducing the risk of developing complications. Lipid profile parameters have been proposed to serve as important predictors of DM. Therefore, this study was conducted on three groups of participants as follows normoglycemic (n=30), pre-diabetics (n=125), and diabetics (n=30), to understand the predictive role of lipid parameters in the transition from pre-diabetes to diabetes. In this experiment, in addition to total cholesterol and triglycerides, very lowdensity lipoprotein (VLDL), low density lipoprotein (LDL), high density lipoprotein (HDL), as well as triglycerides/HDL ratio and fasting triglycerides-fasting blood glucose (FBG) index were masured. The findings indicated that medians for total cholesterol, LDL, HDL, LDL/HDL ratio, cholesterol/HDL ratio, and LDL/HDL ratio did not differ significantly across the groups of those with normoglycemia, pre-diabetes, and diabetes. For triglycerides, their medians were significantly higher in pre-diabetes and diabetes than in normoglycemia; 127.9 and 129.1 vs. 94.5 mg/dL, respectively (p< 0.001). A similar observation was also made in the case of VLDL; 25.6 and 30.9 vs. 18.9 mg/dL, respectively (p< 0.001). It was also viewed that the triglyceride/HDL ratio was significantly increased pre-diabetics and diabetics compared to normoglycemic (2.72 and2.67 vs. 2.18, respectively;p = 0.003). Besides, a significantly increased median of the triglycerides-FBG index was found in pre-diabetics and diabetics compared to normoglycemic (8.89 and 9.38 vs. 8.22, respectively; p< 0.001).The importance of triglycerides, VLDL, the triglyceride/HDL ratio, and the triglycerides-FBG index in distinguishing between pre-diabetes and normoglycemia was verified by a receiver operating characteristic curve analysis of the results.Logistic regression analysis confirmed the risk effects of the four parameters in pre-diabetes and diabetes.In conclusion, triglycerides, VLDL, triglycerides-FBG index, and triglycerides/HDL ratio are proposed to be promising biomarkers that can be used to predict pre-diabetes and DM in the general population. | ||
| کلیدواژه‌ها | ||
| Diabetes؛ Normoglycemia؛ Lipid profile؛ Triglycerides-glucose index؛ Triglycerides/high density lipoprotein ratio | ||
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آمار تعداد مشاهده مقاله: 29 |
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