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Effect of Letrozole administration as a selective aromatase inhibitor on Male Rat's Reproductive performance | ||
| Archives of Razi Institute | ||
| مقالات آماده انتشار، پذیرفته شده، انتشار آنلاین از تاریخ 19 آبان 1400 | ||
| نوع مقاله: Original Articles | ||
| شناسه دیجیتال (DOI): 10.22092/ari.2021.356539.1864 | ||
| نویسندگان | ||
Abbas Hmood Jassim  1؛ Ahmed S. Abed2؛ Ahmed Kareem thamer1؛ Hawraa K. Judi2؛ Assad H. Enad1
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| 1Department of medical laboratory techniques, Hilla University College, Babylon, Iraq | ||
| 2Department of Medical Physics, Hilla University College, Babylon, Iraq | ||
| چکیده | ||
| This study was designed to investigate the effect of the administration of a selective aromatase inhibitor, Letrozole, on Rat sperm parameters and testicles histomorphological parameters. Forty males Wistar rats about 5 months old with average weight of 190±10 gm were divided randomly into four equal groups and treated for 6 weeks as following: First group (C) was given normal saline only as a control group (n=10). Second group (T1) was given Letrozole (0.5 mg/animal) (n=10). Third group (T2) was given Letrozole at a dose of 1 mg/animal, (n=10). The 4th group received 1.5 mg/animal letrozole (n=10). At the end of the experiment (42 days) all animals were euthanized and samples were obtained for more evolutions. The results of this study showed a significant (p≤0.05) increase in sperms quality, and represented a significant decrease in sperms abnormality in T1 group compared with C group. Also there was a significant difference represented by increase in sperms quality, and a significant difference represented by decrease in sperms abnormality in T2 group compared with C group. On the other hand there was a significant difference represented by increase in sperms quality, a significant difference represented by decrease in sperms abnormality in T3group compared with T2 group. Normal somniferous tubules with high spermatoscopy counts have been shown in histologic sections in the control group, primary and secondary spermatocytes with spermatozoa. In T1 group there was adequate spermatogenesis with thick basement membrane. In T2 group there was normal testicular tissue with significant increase in spermatogenic activity and number. In T3 group there was no significant atrophy or other pathology. Results of the current study suggests that letrozole improves spermatogenesis while causing no visible pathological alterations in testis tissue | ||
| کلیدواژه‌ها | ||
| Aromatase inhibitors؛ Letrozole؛ Sperms Parameters؛ Histological section؛ Rat testicles | ||
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آمار تعداد مشاهده مقاله: 3 |
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