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| تعداد نشریات | 279 |
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| تعداد مقالات | 25,673 |
| تعداد مشاهده مقاله | 13,948,049 |
| تعداد دریافت فایل اصل مقاله | 11,184,361 |
Immunohistochemical and electron microscopy evolution in the diagnosis of lung cancer in Iraq | ||
| Archives of Razi Institute | ||
| مقالات آماده انتشار، پذیرفته شده، انتشار آنلاین از تاریخ 19 آبان 1400 | ||
| نوع مقاله: Original Articles | ||
| شناسه دیجیتال (DOI): 10.22092/ari.2021.356552.1870 | ||
| نویسنده | ||
Sabreen Saleem Abd Alkreem Alsaqi 
| ||
| Department of Anatomy, Collage of Medicine, University of Babylon /Iraq | ||
| چکیده | ||
| Lung cancer is considered as the most commonly diagnosed with regard to all cancers, and it kills over 1.76 million people yearly around the world. In this work, the main goal was to see how electron microscopy (EM) and immunohistochemistry worked together. In the current study a total of 50 tissue blocks were used which were embedded in paraffin wax from 20 healthy controls and 30 lung cancer patients (19 males and 11 females), to conduct a histopathological examination, which included hematoxylin and eosin stain, IHC detection regarding the protein expression in p53, and electron microscopy for lung cancer diagnosis. The research's findings indicated that the mean age of the patients was 51.84 ± 15.70 years, and that there was no correlation between the age of patients and the disease's stage. P53 expression was measured using an immunohistochemical technique, while the positive rate showed a highly significant difference between healthy controls and patients (P ≤0.05). The link between p53 expression, age, and gender wasn't significant, although there was a significant correlation with stage and grade. We detected a correlation between p53 immunohistochemistry and electron microscopy (P ≤0.05). In conclusion, detection of immunohistochemical method of lung cancer patients has been (gold standard) useful in detecting subsets of patients. In Addition to good method of electron microscopy in diagnosis of lung cancer patients. | ||
| کلیدواژه‌ها | ||
| Lung adenocarcinoma؛ Immunohistochemical؛ Electron microscopy؛ Prognostic factors | ||
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آمار تعداد مشاهده مقاله: 3 |
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