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Ali Imarah, Ameer, Subhi Mohammed, Mohammed, Ahmed Najm, Rana, Al Zeyadi, Mohammad, Q Khayoon, Sinan, Alhamadani, Isra. (1400). Effectof the concentration levels of growth hormone and insulin like growth factor I on polymorphisms of Il12p40 gene in lung cancer patients. سامانه مدیریت نشریات علمی, (), -. doi: 10.22092/ari.2021.356610.1880
Ameer Ali Imarah; Mohammed Subhi Mohammed; Rana Ahmed Najm; Mohammad Al Zeyadi; Sinan Q Khayoon; Isra Alhamadani. "Effectof the concentration levels of growth hormone and insulin like growth factor I on polymorphisms of Il12p40 gene in lung cancer patients". سامانه مدیریت نشریات علمی, , , 1400, -. doi: 10.22092/ari.2021.356610.1880
Ali Imarah, Ameer, Subhi Mohammed, Mohammed, Ahmed Najm, Rana, Al Zeyadi, Mohammad, Q Khayoon, Sinan, Alhamadani, Isra. (1400). 'Effectof the concentration levels of growth hormone and insulin like growth factor I on polymorphisms of Il12p40 gene in lung cancer patients', سامانه مدیریت نشریات علمی, (), pp. -. doi: 10.22092/ari.2021.356610.1880
Ali Imarah, Ameer, Subhi Mohammed, Mohammed, Ahmed Najm, Rana, Al Zeyadi, Mohammad, Q Khayoon, Sinan, Alhamadani, Isra. Effectof the concentration levels of growth hormone and insulin like growth factor I on polymorphisms of Il12p40 gene in lung cancer patients. سامانه مدیریت نشریات علمی, 1400; (): -. doi: 10.22092/ari.2021.356610.1880

Effectof the concentration levels of growth hormone and insulin like growth factor I on polymorphisms of Il12p40 gene in lung cancer patients

Archives of Razi Institute
مقالات آماده انتشار، پذیرفته شده، انتشار آنلاین از تاریخ 13 آذر 1400  XML
نوع مقاله: Original Articles
شناسه دیجیتال (DOI): 10.22092/ari.2021.356610.1880
نویسندگان
Ameer Ali Imarah email 1؛ Mohammed Subhi Mohammed2؛ Rana Ahmed Najm2؛ Mohammad Al Zeyadi1؛ Sinan Q Khayoon1؛ Isra Alhamadani1
1University of Kufa, Faculty of Science
2Al-Furat Al-Awsat Technical UniversityKufa, Technical Institute
چکیده
The prevalence of lung cancer as one of the most common cancers with the highest mortality rate is one of the most important health problems in humans in the world.Molecular research can provide valuable information about genetic changes associated with the pathogenesis of the disease that may be used to improve prognosis and treatment. Current study was aims to examine genotyping utility of Il12p40(IL-12B) gene (rs3212227, A>C) gene polymorphisms, and to detected the relationwith the concentration of Levels of HGH and IGF-1 for the non- small cell lung carcinoma (NSCLC ).The study consisted of 67 case with NSCLC 60 Male and 7 females and 28 healthy control individuals. Serum level of HGH and IGF-1 was determined by using enzyme-linked immunosorbent assay (ELISA). Genotyping of (IL-12B) gene polymorphisms (rs3212227, A>Cwere carried out by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). The Results were estimate serum level of HGH and IGF-1 and the genotyping of IL-12B results were found increased the risk of NSCLC.The homozygous (AA) genotype of the IL-12 gene showed that the risk of NSCLC was higher than that of the heterozygous (AC) andhomozygous genotype (CC).Also significantly elevated serum levels of HGH in NSCLC patients compared with the control group.The result showed that the IL-12 gene polymorphism were implicated in the pathogenesis of NSCLC, as well as in directing several metabolic changes.
کلیدواژه‌ها
Non- small cell lung carcinoma؛ IL-12؛ Growth hormone؛ Insulin growth factor I؛ Polymorphism
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تعداد مشاهده مقاله: 66


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