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Islam, Fahadul, Akter, Aklima, Mimi, Anjuman Ara, Urme, Humaira, Islam, Md. Rezaul, Rahaman, Md. Saidur, Mamun, Abdullah Al, Rahman, Md. Mominur, Dhama, Kuldeep, Emran, Talha Bin. (1400). Neuropharmacological Effect of Chassalia curviflora (Rubiaceae) Leaves in Swiss Albino Mice Model. سامانه مدیریت نشریات علمی, (), -. doi: 10.22092/ari.2021.356880.1937
Fahadul Islam; Aklima Akter; Anjuman Ara Mimi; Humaira Urme; Md. Rezaul Islam; Md. Saidur Rahaman; Abdullah Al Mamun; Md. Mominur Rahman; Kuldeep Dhama; Talha Bin Emran. "Neuropharmacological Effect of Chassalia curviflora (Rubiaceae) Leaves in Swiss Albino Mice Model". سامانه مدیریت نشریات علمی, , , 1400, -. doi: 10.22092/ari.2021.356880.1937
Islam, Fahadul, Akter, Aklima, Mimi, Anjuman Ara, Urme, Humaira, Islam, Md. Rezaul, Rahaman, Md. Saidur, Mamun, Abdullah Al, Rahman, Md. Mominur, Dhama, Kuldeep, Emran, Talha Bin. (1400). 'Neuropharmacological Effect of Chassalia curviflora (Rubiaceae) Leaves in Swiss Albino Mice Model', سامانه مدیریت نشریات علمی, (), pp. -. doi: 10.22092/ari.2021.356880.1937
Islam, Fahadul, Akter, Aklima, Mimi, Anjuman Ara, Urme, Humaira, Islam, Md. Rezaul, Rahaman, Md. Saidur, Mamun, Abdullah Al, Rahman, Md. Mominur, Dhama, Kuldeep, Emran, Talha Bin. Neuropharmacological Effect of Chassalia curviflora (Rubiaceae) Leaves in Swiss Albino Mice Model. سامانه مدیریت نشریات علمی, 1400; (): -. doi: 10.22092/ari.2021.356880.1937

Neuropharmacological Effect of Chassalia curviflora (Rubiaceae) Leaves in Swiss Albino Mice Model

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مقالات آماده انتشار، پذیرفته شده، انتشار آنلاین از تاریخ 28 آذر 1400  XML
نوع مقاله: Original Articles
شناسه دیجیتال (DOI): 10.22092/ari.2021.356880.1937
نویسندگان
Fahadul Islam1؛ Aklima Akter1؛ Anjuman Ara Mimi1؛ Humaira Urme2؛ Md. Rezaul Islam1؛ Md. Saidur Rahaman1؛ Abdullah Al Mamun3؛ Md. Mominur Rahman1؛ Kuldeep Dhamaorcid 4؛ Talha Bin Emran email orcid 5
1Department of Pharmacy, Faculty of Allied Health Sciences, Daffodil International University, Dhaka 1207, Bangladesh
2Department of Pharmaceutical Science, North South University, Dhaka, Bangladesh
3Molecular Pharmacology Research Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou 325035, Zhejiang Province, China
4Division of Pathology, ICAR-Indian Veterinary Research Institute, Izatnagar, Bareilly 243122, Uttar Pradesh, India
5Assistant Professor, Department of Pharmacy, BGC Trust University Bangladesh
چکیده
The current study aims at the neuropharmacological properties of ethanol, acetone, and ethyl acetate leaf extracts of Chassalia curviflora in mouse models. The neuropharmacological properties were studied in Swiss albino mice, which were provided doses of 50, 100, and 200 mg/kg body weight in thiopental sodium-induced sleeping time, and 100 and 200 mg/kg body weight in other tests. The extracts demonstrated a marked reduction in the initiation and sleep length (*p < 0.05) in studies on thiopental sodium-induced sleeping time at doses of 100 and 200 mg/kg and found a significant decrease (*p < 0.05) in unconstrained locomotors and explorative properties in both hole cross and open field tests at doses of 100 and 200 mg/kg. Furthermore, with a dose-dependent onset of action, the extracts increased sleeping time. The hole-board test extracts also demonstrated a reduced greater number of head dips (*p < 0.05) at doses of 100, and 200 mg/kg. This study found 200 ml/kg is the best dose of C. curviflora for neuropharmacological properties. Our findings also showed that all of the extracts from C. curviflora are experimentally active in an in vivo model. The study suggests that the leaves has strong anti-depressant and hypnotic CNS properties that might be exploited for neuropharmacological adjuvant therapy in conventional medicine. However, pharmacological studies are warranted to explore the active substances and the mode of action.
کلیدواژه‌ها
Chassalia curviflora؛ Locomotive behavior؛ Sleeping time test؛ Hole cross test؛ Hole board test
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تعداد مشاهده مقاله: 95


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