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Shalikar, M, Zendehdel, M, Vazir, B, Asghari, A. (1400). Impact of the Central Histaminergic and Melanocortin Systems on Leptin-Induced Hypophagia in Neonatal Layer Chicken. سامانه مدیریت نشریات علمی, 76(6), 1735-1744. doi: 10.22092/ari.2021.354188.1626
M Shalikar; M Zendehdel; B Vazir; A Asghari. "Impact of the Central Histaminergic and Melanocortin Systems on Leptin-Induced Hypophagia in Neonatal Layer Chicken". سامانه مدیریت نشریات علمی, 76, 6, 1400, 1735-1744. doi: 10.22092/ari.2021.354188.1626
Shalikar, M, Zendehdel, M, Vazir, B, Asghari, A. (1400). 'Impact of the Central Histaminergic and Melanocortin Systems on Leptin-Induced Hypophagia in Neonatal Layer Chicken', سامانه مدیریت نشریات علمی, 76(6), pp. 1735-1744. doi: 10.22092/ari.2021.354188.1626
Shalikar, M, Zendehdel, M, Vazir, B, Asghari, A. Impact of the Central Histaminergic and Melanocortin Systems on Leptin-Induced Hypophagia in Neonatal Layer Chicken. سامانه مدیریت نشریات علمی, 1400; 76(6): 1735-1744. doi: 10.22092/ari.2021.354188.1626

Impact of the Central Histaminergic and Melanocortin Systems on Leptin-Induced Hypophagia in Neonatal Layer Chicken

Archives of Razi Institute
مقاله 19، دوره 76، شماره 6، بهمن و اسفند 2021، صفحه 1735-1744    اصل مقاله (861.92 K)
نوع مقاله: Original Articles
شناسه دیجیتال (DOI): 10.22092/ari.2021.354188.1626
نویسندگان
M Shalikar1؛ M Zendehdel* 2؛ B Vazir1؛ A Asghari3
1Department of Basic Sciences, Faculty of Veterinary Medicine, Science and Research Branch, Islamic Azad University, Tehran, Iran
2Department of Basic Sciences, Faculty of Veterinary Medicine, University of Tehran, 14155-6453, Tehran, Iran
3Department of Clinical Science, Faculty of Veterinary Medicine, Science and Research Branch, Islamic Azad University, Tehran, Iran
چکیده
The present study aimed to assess the probable impact of the central histaminergic and melanocortin systems on leptin-induced hypophagia in neonatal layer chickens. In experiment 1, the chickens received intracerebroventricular (ICV) injections of the control solution, 250 nmol of α-FMH, 10 µg of leptin, and α-FMH+leptin. Experimental groups 2-8 were injected the same as experiment 1. Nonetheless, the chickens in experiments 2-8 received ICV injections of 300 nmol of chlorpheniramine (H1 receptor antagonist), 82 nmol of famotidine (H2 receptor antagonist), 300 nmol of thioperamide (H3 receptor antagonist), 0.5 nmol of SHU9119 (M3/M4 receptors antagonist), 0.5 nmol of MCL0020 (M4 receptor antagonist), 30 µg of astressin-B (CRF1/ CRF2 receptors antagonist), and 30 µg of astressin2-B (CRF2 receptor antagonist), instead of α-FMH, respectively. Food was provided for the birds immediately following the injection, and 30, 60, and 120 min after the injection, cumulative food intake (g) was measured. The findings pointed out that the ICV injection of leptin diminished food intake in neonatal chickens (P<0.05). The co-administration of M3/M4 receptor antagonist+leptin significantly decreased the hypophagic effect of leptin (P<0.05). A significant decrease was also detected in the hypophagic effect of leptin following the co-administration of the M4 receptor antagonist and leptin (P<0.05). Moreover, the co-injection of the antagonists of CRF1/CRF2 receptors and leptin significantly mitigated the hypophagic effect of leptin (P<0.05). The co-injection of CRF2 receptor antagonist and leptin led to a decrease in the hypophagic effect of leptin. As evidenced by the results of the current study the hypophagic effect of leptin is mediated by the receptors of H1, H3, M3/M4, and CRF1/CRF2 in neonatal layer chicken.
کلیدواژه‌ها
Histaminergic؛ Melanocortin؛ Leptin؛ Food intake؛ Neonatal layer chicken
عنوان مقاله [English]
بررسی تداخل سیستم های ملانوکورتینی و هیستامینرژیک مرکزی بر اخذ غذای ناشی از لپتین در جوجه های تخمگذار
چکیده [English]
مطالعه حاضر به منظور بررسی تداخل سیستم های ملانوکورتینی و هیستامینرژیک مرکزی بر اخذ غذای ناشی از لپتین در جوجه های تخمگذار انجام شد. در آزمایش 1، جوجه‌ها، تزریقات داخل بطن مغزی (ICV) را به فرم زیر دریافت کردند: سالین، α-FMH (250 نانومول)، leptin (10 میکروگرم) و leptin + α-FMH را دریافت کردند. آزمایش 2 الی 8 مشابه آزمایش 1 بود به استثنا اینکه جوجه‌ها با Chlorpheniramine (آنتاگونیست گیرنده H1 هیستامینی، 300 نانومول)، famotidine (آنتاگونیست گیرنده H2 هیستامینی، 82 نانومول)، Thioperamide (آنتاگونیست گیرنده H3 هیستامینی، 300 نانومول)، SHU9119 (آنتاگونیست گیرنده های M3/M4 ملانوکورتینی 5/0 نانومول)، MCL0020 (آنتاگونیست گیرنده های M4 ملانوکورتینی 5/0 نانومول)، astressin-B (آنتاگونیست گیرنده‌های CRF1/ CRF2 30 میکروگرم) و astressin2-B (آنتاگونیست گیرنده‌های CRF2 30 میکروگرم) را بجای α-FMH دریافت کردند. سپس مصرف تجمعی غذا تا 120 دقیقه بعد از تزریق اندازه‌گیری شد. با توجه به نتایج بدست آمده، تزریق داخل بطنی مغزی لپتین (10 میکروگرم) موجب کاهش مصرف غذا در جوجه‌های تخمگذار شد (P≤0.05). تزریق توام لپتین +α-FMH یا لپتین + chlorpheniramine موجب مهار اثرات هیپوفاژیک ناشی از لپتین شد (P≤0.05). تزریق لپتین + thioperamide موجب تقویت کاهش اشتهای ناشی از لپتین شد (P≤0.05). تزریق توام SHU9119 + لپتین،MCL0020 + لپتین، لپتین + astressin-B و astressin2-B + لپتین موجب مهار اثرات هیپوفاژیک ناشی از لپتین شد (P≤0.05). نتایج نشان دهنده این بود که هیپوفاژی ناشی از لپتین در تقابل با سیستم‌های ملانوکورتینی و هیستامینرژیک در جوجه‌های تخمگذار است.
کلیدواژه‌ها [English]
سیستم ملانوکورتینی, هیستامین, لپتین, اخذ غذا, جوجه تخمگذار
سایر فایل های مرتبط با مقاله
مراجع
  1. Zendehdel M, Hassanpour S, Movahedi N. Central and peripheral methylamine-induced hypophagia is mediated via nitric oxide and TAAR1 in neonatal layer-type chicken. Neurosci Lett. 2020;739:135408.
  2. Adeli A, Zendehdel M, Babapour V, Panahi N. Interaction between leptin and glutamatergic system on food intake regulation in neonatal chicken: role of NMDA and AMPA receptors. Int J Neurosci. 2020;130(7):713-21.
  3. Irving AJ, Harvey J. Leptin regulation of hippocampal synaptic function in health and disease. Philos Trans R Soc Lond B Biol Sci. 2014;369(1633):20130155.
  4. Doherty GH, Beccano-Kelly D, Yan SD, Gunn-Moore FJ, Harvey J. Leptin prevents hippocampal synaptic disruption and neuronal cell death induced by amyloid beta. Neurobiol Aging. 2013;34(1):226-37.
  5. Rafiei M, Taati M, Alavi S, Nayebzadeh H, Zendehdel M. Effects of intracerebroventricular injection of histamine and H1, H2 receptor antagonists on electrocardiographic parameters in broiler chickens. Iran J Vet Res. 2011;12(3):192-8.
  6. Rozov SV, Zant JC, Karlstedt K, Porkka-Heiskanen T, Panula P. Periodic properties of the histaminergic system of the mouse brain. Eur J Neurosci. 2014;39(2):218-28.
  7. Schneeberger M, Gomis R, Claret M. Hypothalamic and brainstem neuronal circuits controlling homeostatic energy balance. J Endocrinol. 2014;220(2):T25-46.
  8. Ahmadi F, Zendehdel M, Babapour V, Panahi N, Hassanpour S, Khodadadi M. Modulatory function of NMDA glutamate receptor on MC3/MC4 receptors agonist-induced hypophagia in neonatal meat-type chicken. Vet Res Commun. 2017;41(4):241-8.
  9. Zendehdel M, Khodadadi M, Vosoughi A, Mokhtarpouriani K, Baghbanzadeh A. beta2 adrenergic receptors and leptin interplay to decrease food intake in chicken. Br Poult Sci. 2020;61(2):156-63.
  10. Richards MP, Proszkowiec-Weglarz M. Mechanisms regulating feed intake, energy expenditure, and body weight in poultry. Poult Sci. 2007;86(7):1478-90.
  11. Michael NJ, Caron A, Lee CE, Castorena CM, Lee S, Zigman JM, et al. Melanocortin regulation of histaminergic neurons via perifornical lateral hypothalamic melanocortin 4 receptors. Mol Metab. 2020;35:100956.
  12. Gloy VL, Lutz TA, Langhans W, Geary N, Hillebrand JJ. Basal plasma levels of insulin, leptin, ghrelin, and amylin do not signal adiposity in rats recovering from forced overweight. Endocrinology. 2010;151(9):4280-8.
  13. Guo L, Munzberg H, Stuart RC, Nillni EA, Bjorbaek C. N-acetylation of hypothalamic alpha-melanocyte-stimulating hormone and regulation by leptin. Proc Natl Acad Sci U S A. 2004;101(32):11797-802.
  14. Olanrewaju H, Purswell J, Collier SD, Branton SL. Effects of Light Ingress through Ventilation Fan Apertures on Selected Blood Variables of Male Broilers. Int J Poult Sci. 2017;16:288-95.
  15. Blevins JE, Stanley BG, Reidelberger RD. DMSO as a vehicle for central injections: tests with feeding elicited by norepinephrine injected into the paraventricular nucleus. Pharmacol Biochem Behav. 2002;71(1):277-82.
  16. Qi W, Ding D, Salvi RJ. Cytotoxic effects of dimethyl sulphoxide (DMSO) on cochlear organotypic cultures. Hear Res. 2008;236(1-2):52-60.
  17. Davis JL, Masuoka DT, Gerbrandt LK, Cherkin A. Autoradiographic distribution of L-proline in chicks after intracerebral injection. Physiol Behav. 1979;22(4):693-5.
  18. Furuse M, Matsumoto M, Saito N, Sugahara K, Hasegawa S. The central corticotropin-releasing factor and glucagon-like peptide-1 in food intake of the neonatal chick. Eur J Pharmacol. 1997;339(2):211-3.
  19. Van Tienhoven A, Juhasz LP. The chicken telencephalon, diencephalon and mesencephalon in sterotaxic coordinates. J Comp Neurol. 1962;118:185-97.
  20. Jonaidi H, Noori Z. Neuropeptide Y-induced feeding is dependent on GABAA receptors in neonatal chicks. J Comp Physiol A Neuroethol Sens Neural Behav Physiol. 2012;198(11):827-32.
  21. Furuse M, Ando R, Bungo T, Ao R, Shimojo M, Masuda Y. Intracerebroventricular injection of orexins does not stimulate food intake in neonatal chicks. Br Poult Sci. 1999;40(5):698-700.
  22. Saito ES, Kaiya H, Tachibana T, Tomonaga S, Denbow DM, Kangawa K, et al. Inhibitory effect of ghrelin on food intake is mediated by the corticotropin-releasing factor system in neonatal chicks. Regul Pept. 2005;125(1-3):201-8.
  23. Ahmadi F, Zendehdel M, Babapour V, Panahi N. CRF1/CRF2 and MC3/MC4 Receptors Affect Glutamate- Induced Food Intake in Neonatal Meat-Type Chicken. Braz J Poult Sci. 2019;21.
  24. Zendehdel M, Lankarani Mohajer L, Hassanpour S. Central muscarinic receptor subtypes (M1 and M3) involved in carbacol-induced hypophagia in neonatal broiler chicken. Int J Neurosci. 2020;130(2):204-11.
  25. Morton GJ, Blevins JE, Kim F, Matsen M, Figlewicz DP. The action of leptin in the ventral tegmental area to decrease food intake is dependent on Jak-2 signaling. Am J Physiol Endocrinol Metab. 2009;297(1):202-10.
  26. Lamosová D, Mácajová M, Zeman M, Mózes S, Jezová D. Effect of in ovo leptin administration on the development of Japanese quail. Physiol Res. 2003;52(2):201-9.
  27. Hen G, Yosefi S, Ronin A, Einat P, Rosenblum CI, Denver RJ, et al. Monitoring leptin activity using the chicken leptin receptor. J Endocrinol. 2008;197(2):325-33.
  28. Wang D, Xu C, Wang T, Li H, Li Y, Ren J, et al. Discovery and functional characterization of leptin and its receptors in Japanese quail (Coturnix japonica). Gen Comp Endocrinol. 2016;225:1-12.
  29. Masaki T, Chiba S, Yasuda T, Tsubone T, Kakuma T, Shimomura I, et al. Peripheral, but not central, administration of adiponectin reduces visceral adiposity and upregulates the expression of uncoupling protein in agouti yellow (Ay/a) obese mice. Diabetes. 2003;52(9):2266-73.
  30. Toftegaard CL, Knigge U, Kjær A, Warberg J. The role of hypothalamic histamine in leptin-induced suppression of short-term food intake in fasted rats. Regul Pept. 2003;111(1):83-90.
  31. Satoh N, Ogawa Y, Katsuura G, Numata Y, Masuzaki H, Yoshimasa Y, et al. Satiety effect and sympathetic activation of leptin are mediated by hypothalamic melanocortin system. Neurosci Lett. 1998;249(2):107-10.
  32. Halaas JL, Boozer C, Blair-West J, Fidahusein N, Denton DA, Friedman JM. Physiological response to long-term peripheral and central leptin infusion in lean and obese mice. Proc Natl Acad Sci U S A. 1997;94(16):8878-83.
  1. Kenny PJ. Common cellular and molecular mechanisms in obesity and drug addiction. Nat Rev Neurosci. 2011;12(11):638-51.
  2. Dridi S, Swennen Q, Decuypere E, Buyse J. Mode of leptin action in chicken hypothalamus. Brain Res. 2005;1047(2):214-23.
  1. Morimoto I, Yamamoto S, Kai K, Fujihira T, Morita E, Eto S. Centrally administered murine-leptin stimulates the hypothalamus-pituitary- adrenal axis through arginine-vasopressin. Neuroendocrinology. 2000;71(6):366-74.
  2. Uehara Y, Shimizu H, Ohtani K, Sato N, Mori M. Hypothalamic corticotropin-releasing hormone is a mediator of the anorexigenic effect of leptin. Diabetes. 1998;47(6):890-3.
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