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Abed Al-Kareem, Z, Aziz, N. D, Ali Zghair, M. (1401). Hepatoprotective Effect of Coenzyme Q10 in Rats with Diclofenac Toxicity. سامانه مدیریت نشریات علمی, 77(2), 599-605. doi: 10.22092/ari.2022.357210.1998
Z Abed Al-Kareem; N. D Aziz; M Ali Zghair. "Hepatoprotective Effect of Coenzyme Q10 in Rats with Diclofenac Toxicity". سامانه مدیریت نشریات علمی, 77, 2, 1401, 599-605. doi: 10.22092/ari.2022.357210.1998
Abed Al-Kareem, Z, Aziz, N. D, Ali Zghair, M. (1401). 'Hepatoprotective Effect of Coenzyme Q10 in Rats with Diclofenac Toxicity', سامانه مدیریت نشریات علمی, 77(2), pp. 599-605. doi: 10.22092/ari.2022.357210.1998
Abed Al-Kareem, Z, Aziz, N. D, Ali Zghair, M. Hepatoprotective Effect of Coenzyme Q10 in Rats with Diclofenac Toxicity. سامانه مدیریت نشریات علمی, 1401; 77(2): 599-605. doi: 10.22092/ari.2022.357210.1998

Hepatoprotective Effect of Coenzyme Q10 in Rats with Diclofenac Toxicity

Archives of Razi Institute
مقاله 12، دوره 77، شماره 2، خرداد و تیر 2022، صفحه 599-605    اصل مقاله (427.31 K)
نوع مقاله: Original Articles
شناسه دیجیتال (DOI): 10.22092/ari.2022.357210.1998
نویسندگان
Z Abed Al-Kareem1؛ N. D Aziz2؛ M Ali Zghair* 3
1Department of Pharmacology and Toxicology, College of Pharmacy, University of Kerbala, Kerbala, Iraq
2Department of Clinical Pharmacy, College of Pharmacy, University of Kerbala, Kerbala, Iraq
3Department of Pharmaceutics, College of Pharmacy, University of Kerbala, Kerbala, Iraq
چکیده
The liver and kidney are the most important organs in the body, and they both act as target structures for drug-induced injury as a consequence of their functions in metabolisms, detoxifications, storage, elimination of medications, and their metabolites. The present study aimed to examine the role of the natural and free radical scavenger "CoQ10" against diclofenac-induced hepatic and renal tissue injury. In total, 36 adult Wistar rats were randomly divided into three equal groups (n=12). The animals in the control group did not receive any medication or treatments, and the second group included animals that received intramuscular (IM) injection of Diclofenac (DF) (at a dose of 10 mg/kg once daily for 14 days). Moreover, the third group was given the IM injection of DF (at a dose of 10 mg/kg once daily for 14 days) +CoQ10. After 14 days, DF prompted signified hepatic and renal injury indicated by elevated biochemical parameters, such as total serum bilirubin, alkaline phosphatase, aspartate aminotransferase, alanine aminotransferase, blood urea nitrogen, creatinine, and uric acid, compared to the control and the third group. However, the group that received Diclofenac+CoQ10 had significantly lower hepatic and renal dysfunctions, compared to the second treated group. DF toxic effects could be the consequences of mitochondrial dysfunction and free radical effects. Remarkably, therapeutic supplementation of CoQ10 diminished the DF-induced toxic oxidative injury and apoptotic cell death. The protective effects of CoQ10 were attributed to its antioxidants and free radical scavenger activity.
کلیدواژه‌ها
Antioxidant؛ CoQ10؛ Diclofenac؛ Hepatotoxicity؛ Nephrotoxicity
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مراجع
  1. Chen L, Deng H, Cui H, Fang J, Zuo Z, Deng J, et al. Inflammatory responses and inflammation-associated diseases in organs. Oncotarget. 2018;9(6):7204.
  2. Alabi QK, Akomolafe RO. Kolaviron diminishes diclofenac-induced liver and kidney toxicity in wistar rats via suppressing inflammatory events, upregulating antioxidant defenses, and improving hematological indices. Dose-Response. 2020;18(1):1559325819899256.
  3. Heidarian E, Nouri A. Hepatoprotective effects of silymarin against diclofenac-induced liver toxicity in male rats based on biochemical parameters and histological study. Arch Physiol Biochem. 2021;127(2):112-8.
  4. Nouri A, Heidarian E, Nikoukar M. Effects of N-acetyl cysteine on oxidative stress and TNF-α gene expression in diclofenac-induced hepatotoxicity in rats. Toxicol Mech Methods. 2017;27(8):561-7.
  5. Orinya OA, Adenkola AY, Ogbe RJ. Haematological and biochemical studies on the effect of diclofenac sodium on Wistar Rattus norvegicus. Int J Biol Chem. 2016;10(5):2231-42.
  6. Ali SA, Faddah L, Abdel-Baky A, Bayoumi A. Protective effect of L-carnitine and coenzyme Q10 on CCl4-induced liver injury in rats. Sci Pharm. 2010;78(4):881-96.
  7. Çolak DA, Uysal H. Protective effects of coenzyme Q10 and resveratrol on oxidative stress induced by various dioxins on transheterozigot larvae of Drosophila melanogaster. Toxicol Res. 2017;6(4):521-5.
  8. Yoon E, Babar A, Choudhary M, Kutner M, Pyrsopoulos N. Acetaminophen-induced hepatotoxicity: a comprehensive update. J Clin Transl Hepatol. 2016;4(2):131.
  9. David S, Hamilton JP. Drug-induced liver injury. US Gastroenterol Hepatol Rev. 2010;6:73.
  10. Adeyemi WJ, Olayaki LA. Diclofenac–induced hepatotoxicity: Low dose of omega-3 fatty acids have more protective effects. Toxicol Rep. 2018;5:90-5.
  11. El-Sheikh AA, Morsy MA, Mahmoud MM, Rifaai RA, Abdelrahman AM. Effect of coenzyme-Q10 on doxorubicin-induced nephrotoxicity in rats. Advances in pharmacological sciences. 2012;2012.
  12. Lopez-Giacoman S, Madero M. Biomarkers in chronic kidney disease, from kidney function to kidney damage. World J Nephrol. 2015;4(1):57.
  13. Choo S, Nuelle JA. NSAID Use and Effects on Pediatric Bone Healing: A Review of Current Literature. Children. 2021;8(9):821.
  14. Bally M, Dendukuri N, Rich B, Nadeau L, Helin-Salmivaara A, Garbe E, et al. Risk of acute myocardial infarction with NSAIDs in real world use: bayesian meta-analysis of individual patient data. Br Med J. 2017;357.
  15. Almaali HMA, Zghair MA, Farhan NH. The protective Effects of Platelet Rich Plasma in Diclofenac Sodium Induced Toxic Destructive Effects in Rats’ Models. Lat Am J  Pharm. 2021;40(SI):94-9.
  16. Esmaeilzadeh M, Heidarian E, Shaghaghi M, Roshanmehr H, Najafi M, Moradi A, et al. Gallic acid mitigates diclofenac-induced liver toxicity by modulating oxidative stress and suppressing IL-1β gene expression in male rats. Pharm Biol. 2020;58(1):590-6.
  17. Lin Y-S, Liu C-Y, Chen P-W, Wang C-Y, Chen H-C, Tsao C-W. Coenzyme Q10 amends testicular function and spermatogenesis in male mice exposed to cigarette smoke by modulating oxidative stress and inflammation. Am J Transl Res. 2021;13(9):10142.
  18. Quiles JL, Ochoa JJ, Battino M, Gutierrez-Rios P, Nepomuceno EA, Frías ML, et al. Life-long supplementation with a low dosage of coenzyme Q_ {10} in the rat: Effects on antioxidant status and DNA damage. Biofactors. 2005;25(1-4):73-86.
  19. Chen S, Tang Y, Fang W, He T, Chen X, Zhang P. CoQ10 promotes resolution of necrosis and liver regeneration after acetaminophen-induced liver injury. Toxicological Sciences. 2021.
  20. Li Q-w, Yang Q, Liu H-Y, Wu Y-l, Hao Y-H, Zhang X-Q. Protective Role of Coenzyme Q10 in Acute Sepsis-Induced Liver Injury in BALB/c Mice. Biomed Res Int. 2020;2020.
  1. Al-Megrin WA, Soliman D, Kassab RB, Metwally DM, Moneim AEA, El-Khadragy MF. Coenzyme Q10 activates the antioxidant machinery and inhibits the inflammatory and apoptotic cascades against lead acetate-induced renal injury in rats. Front Physiol. 2020;11:64.
  2. Ashkani-Esfahani S, Bagheri F, Emami Y, Esmaeilzadeh E, Azarpira N, Hassanabadi N, et al. Protective effects of co-enzyme Q10 on thioacetamide-induced acute liver damage and its correlation with behavioral, biochemical, and pathological factors. Iran Red Crescent Med J. 2016;18(8).
  3. Zhai J, Bo Y, Lu Y, Liu C, Zhang L. Effects of coenzyme Q10 on markers of inflammation: a systematic review and meta-analysis. PloS One. 2017;12(1):0170172.
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