اخبار و اعلانات

 آمار

تعداد نشریات284
تعداد نشریات سازمان82
تعداد شماره‌ها3,037
تعداد مقالات33,984
تعداد مشاهده مقاله45,778,566
تعداد دریافت فایل اصل مقاله77,192,275
Ibrahim Salih, A, Mohammed Saleh, H, Sulaiman Khalaf, A, Sabbar Ayed, H. (1401). Effect of Moringa oleifera Leaves against Hepatotoxicity Induced by Bisphenol A. سامانه مدیریت نشریات علمی, 77(3), 1083-1089. doi: 10.22092/ari.2022.357266.2005
A Ibrahim Salih; H Mohammed Saleh; A Sulaiman Khalaf; H Sabbar Ayed. "Effect of Moringa oleifera Leaves against Hepatotoxicity Induced by Bisphenol A". سامانه مدیریت نشریات علمی, 77, 3, 1401, 1083-1089. doi: 10.22092/ari.2022.357266.2005
Ibrahim Salih, A, Mohammed Saleh, H, Sulaiman Khalaf, A, Sabbar Ayed, H. (1401). 'Effect of Moringa oleifera Leaves against Hepatotoxicity Induced by Bisphenol A', سامانه مدیریت نشریات علمی, 77(3), pp. 1083-1089. doi: 10.22092/ari.2022.357266.2005
Ibrahim Salih, A, Mohammed Saleh, H, Sulaiman Khalaf, A, Sabbar Ayed, H. Effect of Moringa oleifera Leaves against Hepatotoxicity Induced by Bisphenol A. سامانه مدیریت نشریات علمی, 1401; 77(3): 1083-1089. doi: 10.22092/ari.2022.357266.2005

Effect of Moringa oleifera Leaves against Hepatotoxicity Induced by Bisphenol A

Archives of Razi Institute
مقاله 20، دوره 77، شماره 3، مرداد و شهریور 2022، صفحه 1083-1089    اصل مقاله (1.35 M)
نوع مقاله: Original Articles
شناسه دیجیتال (DOI): 10.22092/ari.2022.357266.2005
نویسندگان
A Ibrahim Salih* 1؛ H Mohammed Saleh2؛ A Sulaiman Khalaf2؛ H Sabbar Ayed2
1Department of Mechanization and Agricultural Equipment, College of Agriculture, Al-Hawija, University of Kirkuk, Kirkuk, Iraq
2Department of Food Sciences and Biotechnology, College of Agriculture, Tikrit University, Tikrit, Iraq
چکیده
Bisphenol A (BPA) is a synthetic compound with alterations in the liver, antioxidant enzymes, and reproductive hormones. The therapeutic potential of Moringa oleifera extract has recently been considered. The present study aimed to estimate the leaf extract of M. oleifera against hepatotoxicity induced by BPA. In total, 44 adult male rats were used in this study, and the experiment was conducted on 11 groups (4 animals per group). The rats were administrated (orally) with 5 and 10 mg/kg BPA and treated (orally) with 100, 200, 300, and 400 mg/kg of the aqueous extract of M. oleifera. After 28 days of challenge, liver enzymes, including aspartate transaminase (AST), alanine aminotransferase (ALT), and alkaline phosphatase (ALP), as well as a pathological study using the liver tissue sections were determined. The findings showed a significant (P≤0.05) increase in the AST, ALT, and ALP in the BPA groups with different histological changes that included the sclerosis of the bile duct surrounded by fibrocytes and lymphocytes infiltration. After treatment with M. oleifera, the liver enzymes and tissue returned to a normal state and showed non-significant (P≤0.05) differences, compared to the control group. According to the results, it can be concluded that the aqueous extract of M. oleifera has a great potential to prevent and improve liver damage of BPA.
کلیدواژه‌ها
Bisphenol A؛ Liver enzymes؛ Moringa oleifera
مراجع
  1. Calafat AM, Weuve J, Ye X, Jia LT, Hu H, Ringer S, et al. Exposure to bisphenol A and other phenols in neonatal intensive care unit premature infants. Environ Health Perspect. 2009;117(4):639-44.
  2. Cao XL, Corriveau J, Popovic S. Levels of bisphenol A in canned soft drink products in Canadian markets. J Agric Food Chem. 2009;57(4):1307-11.
  3. Ehrlich S, Calafat AM, Humblet O, Smith T, Hauser R. Handling of thermal receipts as a source of exposure to bisphenol A.J Am Med Assoc. 2014;311(8):859-60.
  4. Fleisch AF, Sheffield PE, Chinn C, Edelstein BL, Landrigan PJ. Bisphenol A and related compounds in dental materials. Pediatrics. 2010;126(4):760-8.
  5. Iribarne-Duran LM, Artacho-Cordon F, Pena-Caballero M, Molina-Molina JM, Jimenez-Diaz I, Vela-Soria F, et al. Presence of Bisphenol A and Parabens in a Neonatal Intensive Care Unit: An Exploratory Study of Potential Sources of Exposure. Environ Health Perspect. 2019;127(11):117004.
  6. Molina-Molina JM, Jimenez-Diaz I, Fernandez MF, Rodriguez-Carrillo A, Peinado FM, Mustieles V, et al. Determination of bisphenol A and bisphenol S concentrations and assessment of estrogen- and anti-androgen-like activities in thermal paper receipts from Brazil, France, and Spain. Environ Res. 2019;170:406-15.
  7. Vandenberg LN, Hauser R, Marcus M, Olea N, Welshons WV. Human exposure to bisphenol A (BPA). Reprod Toxicol. 2007;24(2):139-77.
  8. Hassan ZK, Elobeid MA, Virk P, Omer SA, ElAmin M, Daghestani MH, et al. Bisphenol A induces hepatotoxicity through oxidative stress in rat model. Oxid Med Cell Longev. 2012;2012:194829.
  9. Doherty LF, Bromer JG, Zhou Y, Aldad TS, Taylor HS. In utero exposure to diethylstilbestrol (DES) or bisphenol-A (BPA) increases EZH2 expression in the mammary gland: an epigenetic mechanism linking endocrine disruptors to breast cancer. Horm Cancer. 2010;1(3):146-55.
  10. Meeker JD, Ehrlich S, Toth TL, Wright DL, Calafat AM, Trisini AT, et al. Semen quality and sperm DNA damage in relation to urinary bisphenol A among men from an infertility clinic. Reprod Toxicol. 2010;30(4):532-9.
  11. Lee M, Kwon J, Chung M-K. Enhanced prediction of potential rodent carcinogenicity by utilizing comet assay and apoptotic assay in combination. Mutat Res Genet Toxicol Environ Mutagen. 2003;541(1):9-19.
  12. Kabuto H, Amakawa M, Shishibori T. Exposure to bisphenol A during embryonic/fetal life and infancy increases oxidative injury and causes underdevelopment of the brain and testis in mice. Life Sci. 2004;74(24):2931-40.
  13. Cinar G, Dogan M. Physiological response of Moringa oleifera exposed to bisphenol A. Bot Serb. 2020;44:183-9.
  14. Parrotta J. Healing plants of Peninsular India. Wallingford, New York: CABI Publishing; 2001.
  15. Makkar HPS, Becker K. Plant Toxins and Detoxification Methods to Improve Feed Quality of Tropical Seeds - Review. Asian-Australas J Anim Sci. 1999;12(3):467-80.
  16. Ashifaq M, Basra S, Ashifaq U. Moringa: A miracle plant for agro‐forestry. J agric soc sci. 2012:115-22.
  17. Moyo B, Masika PJ, Hugo A, Muchenje V. Nutritional characterization of Moringa (Moringa oleifera Lam.) leaves. Afr J Biotechnol. 2011;10:12925-33.
  18. Mishra G, Singh P, Verma R, Kumar S, Srivastav S, Jha K, et al. Traditional uses, phytochemistry and pharmacological properties of Moringa oleifera plant: An overview. Der Pharmacia Lettre. 2011;3:141-64.
  19. Mbikay M. Therapeutic Potential of Moringa oleifera Leaves in Chronic Hyperglycemia and Dyslipidemia: A Review. Front Pharmacol. 2012;3:24.
  20. Tn S, P A, V D, Murthy P. Moringa oleifera Lam. leaves prevent cyclophosphamide-induced micronucleus and DNA damage in mice. Int J Phytomedicine. 2010;2:147-54.
  1. Fakurazi S, Hairuszah I, Nanthini U. Moringa oleifera Lam prevents acetaminophen induced liver injury through restoration of glutathione level. Food Chem Toxicol. 2008;46(8):2611-5.
  2. Adedapo A, Mogbojuri O, Emikpe B. Safety evaluations of the aqueous extract of the leaves of Moringa oleifera. J Med Plant Res. 2009;3:586-91.
  3. Saleh A. Potential Role of Titanium Dioxide (TiO2) Nanoparticles against the Toxicity of Leishmania Tropica in Adult Albino Male Rats. J Glob Pharma Technol. 2019.
  4. Saleh AH. The Potential Effect of Grape Seeds Extract against Lead toxicity That Induces Infertility to Male Rats. Tikrit J Pure Sci. 2018;23:70-4.
  5. Mohammed MJ, Thalij KM. The Effectiveness of Two Species of Lactic Acid Bacteria Lactobacillus casei and Lb. acidophilus in Some Biological Parameters of Rats Exposed to the Bisphenol-A. Tikrit J Agric Sci. 2019;15(2):34-44.
  6. Korkmaz A, Ahbab MA, Kolankaya D, Barlas N. Influence of vitamin C on bisphenol A, nonylphenol and octylphenol induced oxidative damages in liver of male rats. Food Chem Toxicol. 2010;48(10):2865-71.
  7. Elhamalawy O, Eissa F, El makawy A, El-Bamby M. Bisphenol-A Hepatotoxicity and the Protective Role of Sesame Oil in Male Mice. Jordan Journal of Biological Sciences. 2018;11.
  8. Ganatra T, Umang J, Payal B, Tusharbindu D, Tirgar DP. A Panoramic View On Pharmacognostic, Pharmacological, Nutritional, Therapeutic And Prophylactic Values Of Moringa Oleifera Lam.Int Res J Pharm. 2012;3:1-7.
  9. Halaby M, Omar A. Effect of Moringa Oleifera on serum lipids and kidney function of hyperlipidemic rats. J Appl Sci Res. 2013;9:5189-98.
  10. Asiedu-Gyekye IJ, Frimpong-Manso S, Awortwe C, Antwi DA, Nyarko AK. Micro- and Macroelemental Composition and Safety Evaluation of the Nutraceutical Moringa oleifera Leaves. J Toxicol. 2014;2014:786979.
  11. Oyagbemi AA, Omobowale TO, Azeez IO, Abiola JO, Adedokun RA, Nottidge HO. Toxicological evaluations of methanolic extract of Moringa oleifera leaves in liver and kidney of male Wistar rats. J Basic Clin Physiol Pharmacol. 2013;24(4):307-12.
آمار
تعداد مشاهده مقاله: 1,625
تعداد دریافت فایل اصل مقاله: 2,668


counter
سامانه مدیریت نشریات علمی. طراحی و پیاده سازی از سیناوب