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Kazemi, M, Aliyari, H, Golabi, S, Tekieh, E, Tavakoli, H, Saberi, M, Meftahi, Gh. H, Sahraei, H. (1400). Improvement of Cognitive Indicators in Male Monkeys Exposed to Extremely Low-Frequency Electromagnetic Fields. سامانه مدیریت نشریات علمی, 77(1), 503-511. doi: 10.22092/ari.2020.352384.1560
M Kazemi; H Aliyari; S Golabi; E Tekieh; H Tavakoli; M Saberi; Gh. H Meftahi; H Sahraei. "Improvement of Cognitive Indicators in Male Monkeys Exposed to Extremely Low-Frequency Electromagnetic Fields". سامانه مدیریت نشریات علمی, 77, 1, 1400, 503-511. doi: 10.22092/ari.2020.352384.1560
Kazemi, M, Aliyari, H, Golabi, S, Tekieh, E, Tavakoli, H, Saberi, M, Meftahi, Gh. H, Sahraei, H. (1400). 'Improvement of Cognitive Indicators in Male Monkeys Exposed to Extremely Low-Frequency Electromagnetic Fields', سامانه مدیریت نشریات علمی, 77(1), pp. 503-511. doi: 10.22092/ari.2020.352384.1560
Kazemi, M, Aliyari, H, Golabi, S, Tekieh, E, Tavakoli, H, Saberi, M, Meftahi, Gh. H, Sahraei, H. Improvement of Cognitive Indicators in Male Monkeys Exposed to Extremely Low-Frequency Electromagnetic Fields. سامانه مدیریت نشریات علمی, 1400; 77(1): 503-511. doi: 10.22092/ari.2020.352384.1560

Improvement of Cognitive Indicators in Male Monkeys Exposed to Extremely Low-Frequency Electromagnetic Fields

Archives of Razi Institute
مقاله 62، دوره 77، شماره 1، فروردین و اردیبهشت 2022، صفحه 503-511    اصل مقاله (901.98 K)
نوع مقاله: Original Articles
شناسه دیجیتال (DOI): 10.22092/ari.2020.352384.1560
نویسندگان
M Kazemi1؛ H Aliyari2؛ S Golabi3؛ E Tekieh1؛ H Tavakoli1؛ M Saberi4؛ Gh. H Meftahi1؛ H Sahraei* 1
1Neuroscience Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran
2Center for Human-Engaged Computing, Kochi University of Technology, Kochi, Japan
3Department of Medical Physiology, School of Medicine, Abadan University of Medical Sciences, Abadan, Iran
4Department of Pharmacology and Toxicology, Faculty of Pharmacy, Baqiyatallah University of Medical Sciences, Tehran, Iran
چکیده
Today, the production of extremely low-frequency electromagnetic fields (ELF-EMFs) has significantly increased. This study aimed to investigate the effect of the ELF-EMFs on the structure and function of the brain in male rhesus monkeys in terms of visual learning (VL), visual memory (VM), and visual working memory (VWM). To conduct the study, four monkeys were selected, of whom two monkeys were irradiated by 12-Hz ELF-EMFs with a magnitude of 0.7 microtesla, and two monkeys were tested without irradiation (control group). A blood sample was taken in three stages, namely pre- and post-irradiated and the recovery phases. Changes in the plasma levels of sodium, potassium, and adrenocorticotropic hormone (ACTH) were evaluated. Moreover, gene expression of N-methyl-D-aspartate (NMDA) receptors was assessed. The anatomical change of the brain’s prefrontal area was measured by magnetic resonance imaging and Digital Imaging and Communications in Medicine LiteBox file. The abilities of VL, VM, and VWM significantly improved after the irradiation. Furthermore, the expression of the NMDA receptors gene and the plasma levels of sodium, potassium, and ACTH significantly enhanced after the irradiation. However, the prefrontal area was not significantly affected by the irradiation. No significant differences were observed in any of the studied factors in the control group. Our findings suggested that ELF-EMFs irradiation at 12 Hz positively affected VL and VWM. Consequently, 12-Hz ELF-EMFs irradiations can be widely applied to improve cognitive abilities in monkeys.
کلیدواژه‌ها
Adrenocorticotropic hormone؛ Extremely Low-frequency electromagnetic fields؛ Rhesus monkey؛ Visual learning؛ Visual memory؛ Visual working memory
عنوان مقاله [English]
بهبود شاخص های شناختی میمون های نر که در مواجهه با میادین الکترومغناطیسی با فرکانس بسیار پایین، گزارش علمی
چکیده [English]
امروزه، تولید میدان های الکترومغناطیسی با فرکانس بسیار کم (ELF-EMF) به طور قابل توجهی افزایش یافته است. این مطالعه با هدف بررسی تأثیر ELF-EMF در ساختار و عملکرد مغز در میمون های نر رزوس از نظر یادگیری بصری (VL)، حافظه بصری (VM) و حافظه کاری بصری (VWM) انجام شد. چهار میمون انتخاب شدند که از آن ها دو میمون توسط ELF-EMF با شدت 0.7 میکروتسلا، 12 هرتز، و دو میمون بدون تابش تحت آزمایش قرار گرفتند (گروه کنترل). یک نمونه خون در سه مرحله، قبل، بعد از تابش و مراحل بهبودی گرفته شد. تغییرات سطح پلاسمایی سدیم، پتاسیم و هورمون آدرنوکورتیکوتروپیک (ACTH) بررسی شد. همچنین، بیان ژن گیرنده های N-methyl-D-aspartate (NMDA) ارزیابی شد. تغییر آناتومیکی ناحیه پیشانی مغز توسط تصویربرداری تشدید مغناطیسی (MRI) و تصویربرداری دیجیتال و ارتباطات پزشکی (DICOM) فایل LiteBox ارزیابی شد. توانایی یادگیری بصری، حافظه بصری و حافظه فعال بصری پس از تابش به طور قابل توجهی بهبود یافت. همچنین، بیان ژن گیرنده های NMDA و سطح سدیم، پتاسیم و ACTH در پلاسما پس از تابش به طور قابل توجهی افزایش یافت. با این حال، منطقه Prefrontal به طور قابل توجهی تحت تابش قرار نگرفت. تفاوت معنی داری در هیچ یک از عوامل مورد مطالعه در گروه کنترل مشاهده نشد. یافته های ما نشان می دهد که تابش ELF-EMF در 12 هرتز، یادگیری بصری و حافظه کار بصری را تحت تأثیر قرار می دهد. بنابراین ، تابش های 12 هرتز ELF-EMF می توانند به طور گسترده ای برای بهبود توانایی های شناختی در میمون ها استفاده شوند
کلیدواژه‌ها [English]
هورمون Adrenocorticotropic, میدانهای الکترومغناطیسی با فرکانس بسیار کم, میمون Rhesus, یادگیری بصری, حافظه کار بصری
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