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Hassani, K. M. (1400). Investigation of the Effect of Atorvastatin on Skeletal Muscles in Male Rats and the Involved Mechanisms. سامانه مدیریت نشریات علمی, 77(1), 285-291. doi: 10.22092/ari.2021.356683.1895
K. M Hassani. "Investigation of the Effect of Atorvastatin on Skeletal Muscles in Male Rats and the Involved Mechanisms". سامانه مدیریت نشریات علمی, 77, 1, 1400, 285-291. doi: 10.22092/ari.2021.356683.1895
Hassani, K. M. (1400). 'Investigation of the Effect of Atorvastatin on Skeletal Muscles in Male Rats and the Involved Mechanisms', سامانه مدیریت نشریات علمی, 77(1), pp. 285-291. doi: 10.22092/ari.2021.356683.1895
Hassani, K. M. Investigation of the Effect of Atorvastatin on Skeletal Muscles in Male Rats and the Involved Mechanisms. سامانه مدیریت نشریات علمی, 1400; 77(1): 285-291. doi: 10.22092/ari.2021.356683.1895

Investigation of the Effect of Atorvastatin on Skeletal Muscles in Male Rats and the Involved Mechanisms

Archives of Razi Institute
مقاله 38، دوره 77، شماره 1، فروردین و اردیبهشت 2022، صفحه 285-291    اصل مقاله (895.63 K)
نوع مقاله: Original Articles
شناسه دیجیتال (DOI): 10.22092/ari.2021.356683.1895
نویسنده
K. M Hassani*
College of Science, University of Misan, Maysan, Iraq
چکیده
It has been approved that atrovastatin is a preferred treatment for hyperlipidemia. One of the atrovastatin drawbacks would be the detrimental effects on skeletal muscles. Therefore, the current study was designed to evaluate all the skeletal muscles alteration in rats' after administration of atrovastatin and identification the mechanisms involved in these structural alterations in the skeletal muscles. A total of 12 healthy adult male rats (Rattus norvegicus) were randomly divided into two groups (n=6). The control group (G1) included rats that received distilled water as the placebo, and the treatment group (G2) included animals that were treated with atorvastatin (80 mg/kg/day) dissolved in distilled water and administrated by a gastric tube for eight weeks. At the end of the experiment, trapezius and vastus medialis muscle tissues were sampled and fixed with 10% formalin for histopathological studies. Atorvastatin administration gave rise to morphological changes in the skeletal muscle fibers and the nerve fibers, including atrophied myofibers, infarction, irregular arrangement of myonuclei, disappearance of nuclei from their normal peripheral position with acute skeletal muscular infarction, and infiltration of accumulated inflammatory cells. Atorvastatin has been revealed to have several adverse effects on the skeletal muscle and the nerve supply. Based on the data in the current study, it is evident that atorvastatin administration for less than two months resulted in some sorts of myotoxic structural changes and apoptosis as evident by deformity and lack of striation degeneration of nuclei, as well as splitting of the muscle fibers in the adult male rats' skeletal muscle.
کلیدواژه‌ها
Hyperlipidemia؛ Low-density lipoprotein cholesterol؛ Myofibers
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مراجع
  1. Boulanger-Piette A, Bergeron J, Desgreniers J, Cote-Levesque M, Brassard D, Joanisse DR, et al. [Statin intolerance and associated muscular dysfunctions]. Med Sci (Paris). 2015;31(12):1109-14.
  2. Ueda P, Lung TW, Lu Y, Salomon JA, Rahimi K, Clarke P, et al. Treatment gaps and potential cardiovascular risk reduction from expanded statin use in the US and England. PLoS One. 2018;13(3):0190688.
  3. Moghadam-Kia S, Oddis CV, Aggarwal R. Approach to asymptomatic creatine kinase elevation. Cleve Clin J Med. 2016;83(1):37-42.
  4. Tomaszewski M, Stępień KM, Tomaszewska J, Czuczwar SJ. Statin-induced myopathies. Pharmacol Rep. 2011;63(4):859-66.
  5. Graham DJ, Staffa JA, Shatin D, Andrade SE, Schech SD, La Grenade L, et al. Incidence of hospitalized rhabdomyolysis in patients treated with lipid-lowering drugs. JAMA. 2004;292(21):2585-90.
  6. Arora R, Liebo M, Maldonado F. Statin-induced myopathy: the two faces of Janus. J Cardiovasc Pharmacol Ther. 2006;11(2):105-12.
  7. El-Gamal DA, Ahmed SF. Effect of green tea on aged rat skeletal muscle: a light and electron microscopic study. Egypt J Histol. 2012;35(2).
  8. Gissler MC, Anto-Michel N, Pennig J, Scherrer P, Li X, Marchini T, et al. Genetic Deficiency of TRAF5 Promotes Adipose Tissue Inflammation and Aggravates Diet-Induced Obesity in Mice. Arterioscler Thromb Vasc Biol. 2021;41(10):2563-74.
  9. Ruano G, Seip R, Windemuth A, Wu AH, Thompson PD. Laboratory Medicine in the Clinical Decision Support for Treatment of Hypercholesterolemia: Pharmacogenetics of Statins. Clin Lab Med. 2016;36(3):473-91.
  10. Anto Michel N, Colberg C, Buscher K, Sommer B, Pramod AB, Ehinger E, et al. Inflammatory Pathways Regulated by Tumor Necrosis Receptor-Associated Factor 1 Protect From Metabolic Consequences in Diet-Induced Obesity. Circ Res. 2018;122(5):693-700.
  11. Basu D, Hu Y, Huggins LA, Mullick AE, Graham MJ, Wietecha T, et al. Novel Reversible Model of Atherosclerosis and Regression Using Oligonucleotide Regulation of the LDL Receptor. Circ Res. 2018;122(4):560-7.
  12. Schaefer WH, Lawrence JW, Loughlin AF, Stoffregen DA, Mixson LA, Dean DC, et al. Evaluation of ubiquinone concentration and mitochondrial function relative to cerivastatin-induced skeletal myopathy in rats. Toxicol Appl Pharmacol. 2004;194)1(:10-23.
  13. Silva M, Matthews ML, Jarvis C, Nolan NM, Belliveau P, Malloy M, et al. Meta-analysis of drug-induced adverse events associated with intensive-dose statin therapy. Clin Ther. 2007;29(2):253-60.
  1. Eng CM, Smallwood LH, Rainiero MP, Lahey M, Ward SR, Lieber RL. Scaling of muscle architecture and fiber types in the rat hindlimb. J Exp Biol. 2008;211(14):2336-45.
  2. Pulipati VP, Davidson MH. How I treat statin-associated side effects in an outpatient setting. Future Cardiol. 2021;17(7):1249-60.
  3. Vaughan CJ, Gotto AM, Jr. Update on statins: 2003. Circulation. 2004;110(7):886-92.
  4. Mokhmer S, Saber E, Hamouda A, Rifaai R. Structural Changes in the Skeletal Muscle Fiber of Adult Male Albino Rat Following Atorvastatin Treatment; the Possible Mechanisms of Atorvastatin Induced Myotoxicity. J Cytol Histol. 2017;08.
 

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