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Tracing of Some Salivary immune Elements in Iraqi SARS-2 patients | ||
| Archives of Razi Institute | ||
| مقالات آماده انتشار، پذیرفته شده، انتشار آنلاین از تاریخ 27 فروردین 1401 | ||
| نوع مقاله: Original Articles | ||
| شناسه دیجیتال (DOI): 10.22092/ari.2022.358330.2195 | ||
| نویسندگان | ||
Sabah Qaysar Musa  1؛ Marwa Mohammed AliJassim1؛ Majid Mohammed Mahmood2
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| 1College of Dentistry, Al-Muthanna University, Al-Muthanna, Iraq | ||
| 2Department of Biology, College of Science, Mustansiriyah University, Baghdad, Iraq | ||
| چکیده | ||
| Saliva is one of the most significant components in maintaining oral homeostasis and symbiosis; it contains antimicrobial proteins and peptides such as mucins, lactoferrin, lysozyme, lactoperoxidase, Catherine, statins, and antibodies (secretory immunoglobin A, sIgA). Early defenses against respiratory infections rely heavily on mucosal immunity, especially secretory sIgA. It has several features and functions which make it suitable for mucosal defense. Salivary testing has been utilized to define mucosal immune responses to SARS-2 infection. lysozyme has muramidase, with antimicrobial activity, and of high concentrations in body fluids such as saliva, and tear. This research intends to offer an update on how saliva components suppress viral infection and sustain health. A total of 50 (30 SARS-2 patients and 20 non-infected) individuals whose ages ranged between 32 and 54 years were enrolled in this study. Saliva specimens were obtained from PCR-confirmed COVID-19 patients and non-infected participants. To collect saliva, they were advised to swirl water over their lips three times. 5.0 ml were collected. Samples were centrifuged for 10 minutes at 800 x g.Saliva was diluted at 1:2,000 with 1× Diluent N. The IgA titer in saliva was detected. A spectrophotometer was used to measure the solution's change in absorbance at 550 nm. Measurements (salivary IgA and lysozyme) were made after 7, 30, and 60 days of confirmatory PCR COVID-19 test. The mean salivary IgA levels in patients were 17.85, 15.26, and 10.73 mg/dl after the 7, 30, and 60 days period compared to its values in healthy individuals (9.53, 10.33, and 9.21mg/dl, respectively). Whereas, the salivary lysozyme activity level in SARS-2 patients compared to controls were (9.7, 7.3, and 4.2mg/dl) (2.9, 3.4, and 3.77mg/dl)respectively. The salivary IgA level was significantly higher in patients of a confirmatory test for COVID-19 compared to healthy individuals | ||
| کلیدواژه‌ها | ||
| SARS- 2؛ COVID-19؛ IgA؛ Lysozyme | ||
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آمار تعداد مشاهده مقاله: 14 |
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