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Hassan Yousef, M, Abdulmunem Abdulhameed, R, Talib Yaseen Aldossary, A. (1401). Effect of Betaine on Blood Parameters Related to the Iron Status in Acrylamide-Treated Rats. سامانه مدیریت نشریات علمی, 77(3), 1241-1247. doi: 10.22092/ari.2022.357804.2101
M Hassan Yousef; R Abdulmunem Abdulhameed; A Talib Yaseen Aldossary. "Effect of Betaine on Blood Parameters Related to the Iron Status in Acrylamide-Treated Rats". سامانه مدیریت نشریات علمی, 77, 3, 1401, 1241-1247. doi: 10.22092/ari.2022.357804.2101
Hassan Yousef, M, Abdulmunem Abdulhameed, R, Talib Yaseen Aldossary, A. (1401). 'Effect of Betaine on Blood Parameters Related to the Iron Status in Acrylamide-Treated Rats', سامانه مدیریت نشریات علمی, 77(3), pp. 1241-1247. doi: 10.22092/ari.2022.357804.2101
Hassan Yousef, M, Abdulmunem Abdulhameed, R, Talib Yaseen Aldossary, A. Effect of Betaine on Blood Parameters Related to the Iron Status in Acrylamide-Treated Rats. سامانه مدیریت نشریات علمی, 1401; 77(3): 1241-1247. doi: 10.22092/ari.2022.357804.2101

Effect of Betaine on Blood Parameters Related to the Iron Status in Acrylamide-Treated Rats

Archives of Razi Institute
مقاله 41، دوره 77، شماره 3، مرداد و شهریور 2022، صفحه 1241-1247    اصل مقاله (751.3 K)
نوع مقاله: Original Articles
شناسه دیجیتال (DOI): 10.22092/ari.2022.357804.2101
نویسندگان
M Hassan Yousef* 1؛ R Abdulmunem Abdulhameed1؛ A Talib Yaseen Aldossary2
1Department of Physiology, Biochemistry, and Pharmacology, College of Veterinary Medicine, University of Baghdad, Baghdad, Iraq
2Department of Physiology, College of Medicine, University of Anbar, Ramadi, Iraq
چکیده
It has been well documented that acrylamide (ACR) is a human carcinogen. One of the consequences of ACR exposure is central and peripheral nervous system damage, which may lead to hallucinations, drowsiness, and numbness in the hands, as well as legs. Betaine (BET) plays an active role in methylation reactions, including DNA methylation, the integrity of cell membranes, and memory development. It has been approved that BET protects the liver from oxidative stress-inducing substances, such as ethanol, and nonalcoholic fatty liver, brain, kidney, stomach, as well as ovaries, in rats. Therefore, this study was designed to investigate how BET influences iron-related blood parameters and biomarkers in acrylamide-treated rats. Twenty adult rats, weighing 180-200 g and aging 6-7 weeks, were randomly divided into four equal groups and given the following treatments every day for 30 days. The control group was identified as G1. Animals in the G2 group were intubated with BET [250 mg/kg body weight (B.W.)]. Animals in the G3 group were intubated with ACR (1 mg/kg B.W.), while animals in the G4 group were intubated with both BET and ACR at the same doses as animals in G2 and G3 groups. At the end of the experiment, blood samples were collected from anesthetized rats using the cardiac puncture technique for measuring white blood cell count, as well as their differential count, red blood cells count, hemoglobin, and their related parameters, including mean corpuscular volume, mean corpuscular hemoglobin concentration, mean corpuscular hemoglobin, hematocrit, as well as red cell distribution width. Additionally, serum was taken to measure serum iron concentration, ferritin, total iron-binding capacity, and transferrin saturation percentage. The results showed significant changes in some hematological parameters and the iron status correlated with anemia in the G3 group, treated with ACR. Such changes, accompanied by histopathological changes in the spleen oral intubation of BET alone, as well as its combination with ACR, caused the alleviation of anemia through correcting previous parameters. In conclusion, the findings revealed that BET positively influences anemia in rats treated with ACR.
کلیدواژه‌ها
Acrylamide؛ Betaine؛ Hemoglobin؛ Iron؛ White blood cells
مراجع
  1. Hedemann MS, Theil PK, Lærke HN, Bach Knudsen KE. Distinct difference in absorption pattern in pigs of betaine provided as a supplement or present naturally in cereal dietary fiber. J Agric Food Chem. 2015;63(10):2725-33.
  2. Hu Y, Sun Q, Zong Y, Liu J, Idriss AA, Omer NA, et al. Prenatal betaine exposure alleviates corticosterone-induced inhibition of CYP27A1 expression in the liver of juvenile chickens associated with its promoter DNA methylation. Gen Comp Endocrinol. 2017;246:241-8.
  3. Hogeveen M, den Heijer M, Semmekrot BA, Sporken JM, Ueland PM, Blom HJ. Umbilical choline and related methylamines betaine and dimethylglycine in relation to birth weight. Pediatr Res. 2013;73(6):783-7.
  4. Lee SY, Ko KS. Effects of S-adenosylmethionine and its combinations with taurine and/or betaine on glutathione homeostasis in ethanol-induced acute hepatotoxicity. J Cancer Prev. 2016;21(3):164.
  5. Alirezaei M, Jelodar G, Ghayemi Z, Mehr MK. Antioxidant and methyl donor effects of betaine versus ethanol-induced oxidative stress in the rat liver. J Comp Pathol. 2014;23(1):161-8.
  6. Rommens CM, Yan H, Swords K, Richael C, Ye J. Low‐acrylamide French fries and potato chips. Plant Biotechnol J. 2008;6(8):843-53.
  7. Freisling H, Moskal A, Ferrari P, Nicolas G, Knaze V, Clavel-Chapelon F, et al. Dietary acrylamide intake of adults in the European Prospective Investigation into Cancer and Nutrition differs greatly according to geographical region. Eur J Nutr. 2013;52(4):1369-80.
  8. Watzek N, Böhm N, Feld J, Scherbl D, Berger F, Merz KH, et al. N7-glycidamide-guanine DNA adduct formation by orally ingested acrylamide in rats: a dose-response study encompassing human diet-related exposure levels. Chem Res Toxicol. 2012;25(2):381-90.
  9. Allam AA, Abdul-Hamid M, Bakry A, El-Ghareeb A, Ajarem JS, Sabri M. Effect of acrylamide on cerebral neurons development in albino rat. Life Science Journal. 2013;10(3):1814-25.
  10. Zhang L, Gavin T, Barber DS, LoPachin RM. Role of the Nrf2-ARE pathway in acrylamide neurotoxicity. Toxicol Lett. 2011;205(1):1-7.
  11. DeWoskin R, Sweeney L, Teeguarden J, Sams 2nd R, Vandenberg J. Comparison of PBTK model and biomarker based estimates of the internal dosimetry of acrylamide. Food Chem Toxicol. 2013;58:506-21.
  12. Al-Azkawi AS, Al-Bahry SN, Mahmoud IY, Barry MJ. Effect of acrylamide on liver proteins expression in mice. J Food Res. 2013;2(5):132.
  13. Besaratinia A, Pfeifer GP. A review of mechanisms of acrylamide carcinogenicity. Carcinogenesis. 2007;28(3):519-28.
  14. Al-Sowayan NS. Effects of acrylamide and children snack food on sex hormones nucleic acid and chromosomes of mature male Wister rats. World J Pharm Res. 2014:1425-34.
  15. Nixon BJ, Katen AL, Stanger SJ, Schjenken JE, Nixon B, Roman SD. Mouse spermatocytes express CYP2E1 and respond to acrylamide exposure. PloS one. 2014;9(5):e94904.
  16. Ramadhan SJ, Khudair K. Effect of Betaine and or Acrylamide on Serum Lipids Profile and Antioxidant Status of Female Rats. Indian J Nat Sci. 2018;9:51.
  17. Khudiar KK. Effect of acrylamide and fructose on some parameters related to metabolic syndrome in adult male rats: Faisal Ali Lateef Al-Agele and Khalisa Khadhim Khudiar. Iraqi J Vet Sci. 2016;40(1):125-35.
  18. Ganesan B, Anandan R, Lakshmanan PT. Studies on the protective effects of betaine against oxidative damage during experimentally induced restraint stress in Wistar albino rats. Cell Stress Chaperones. 2011;16(6):641-52.
  19. Moeckel GW, Shadman R, Fogel JM, Sadrzadeh SM. Organic osmolytes betaine, sorbitol and inositol are potent inhibitors of erythrocyte membrane ATPases. Life Sciences. 2002;71(20):2413-24.
  20. Ximenes VF, Lopes MG, Petrônio MS, Regasini LO, Siqueira Silva DH, da Fonseca LM. Inhibitory Effect of Gallic Acid and Its Esters on 2,2′-Azobis(2-amidinopropane)hydrochloride (AAPH)-Induced Hemolysis and Depletion of Intracellular Glutathione in Erythrocytes. J Agric Food Chem. 2010;58(9):5355-62.
  21. Al-Jowari SA-k. Effect of garlic powder (Allium sativum) on blood constituents in male rabbits. Al-Nahrain J Sci. 2014;17(3):132-7.
  22. Barber D, Hunt J, Ehrich M, Lehning E, LoPachin R. Metabolism, toxicokinetics and hemoglobin adduct formation in rats following subacute and subchronic acrylamide dosing. Neurotoxicology. 2001;22(3):341-53.
  23. Osman M, Romeilah R, Elgammal M, Ramis E, Hasan R. Subchronic toxicity of acrylamide in fried rice and preventive effect of grape leaves. Asian Journal of Biochemistry. 2016;11(2):68-81.
  24. Gargas ML, Kirman CR, Sweeney L, Tardiff RG. Acrylamide: Consideration of species differences and nonlinear processes in estimating risk and safety for human ingestion. Food Chem Toxicol. 2009;47(4):760-8.
  1. Ghorbel I, Chaabane M, Elwej A, Kallel C, Grati Kamoun N, Najiba Z. Extra Virgin olive oil mitigates hematotoxicity induced by acrylamide and oxidative damage in adult rats. Pharm Biomed Res. 2017;3(1):34-40.
  2. Al-Maskari MY, Waly MI, Ali A, Al-Shuaibi YS, Ouhtit A. Folate and vitamin B12 deficiency and hyperhomocysteinemia promote oxidative stress in adult type 2 diabetes. Nutrition. 2012;28(7-8):e23-e6.
  3. Meck WH, Williams CL. Metabolic imprinting of choline by its availability during gestation: implications for memory and attentional processing across the lifespan. Neurosci Biobehav Rev. 2003;27(4):385-99.
  4. Baggott JE, Tamura T. Homocysteine, iron and cardiovascular disease: a hypothesis. Nutrients. 2015;7(2):1108-18.
  5. Chen H-M, Wang Y-P, Chang JY-F, Wu Y-C, Cheng S-J, Sun A. Significant association of deficiencies of hemoglobin, iron, folic acid, and vitamin B12 and high homocysteine level with oral lichen planus. J Formos Med Assoc. 2015;114(2):124-9.
  6. Katre P, Bhat D, Lubree H, Otiv S, Joshi S, Joglekar C, et al. Vitamin B12 and folic acid supplementation and plasma total homocysteine concentrations in pregnant Indian women with low B12 and high folate status. Asia Pac J Clin Nutr. 2010;19(3):335-43.
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