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Effect of Betaine on Blood Parameter Related to Iron Status in Acrylamide Treated Rats | ||
| Archives of Razi Institute | ||
| مقالات آماده انتشار، پذیرفته شده، انتشار آنلاین از تاریخ 01 اردیبهشت 1401 | ||
| نوع مقاله: Original Articles | ||
| شناسه دیجیتال (DOI): 10.22092/ari.2022.357804.2101 | ||
| نویسندگان | ||
Muna Hassan Yousef  1؛ Raed Abdulmunem Abdulhameed1؛ Ahmed Talib yaseen AL-dossary2
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| 1Departments of physiology, Biochemistry and Pharmacology, College of Veterinary Medicine, University of Baghdad, Iraq | ||
| 2Departments of physiology, College of Medicine, University of Anbar | ||
| چکیده | ||
| It has been well documented that acrylamide (ACR) is a human carcinogen. Central and peripheral nervous system damage is considered as one of the consequences of ACR exposure which may lead to hallucinations, drowsiness and numbness in the hands and legs. Betaine (BET) plays an active role in methylation reactions especially in DNA methylation, the integrity of cell membranes, and memory development. It has been approved that BET protects the liver from oxidative stress-inducing substances such as ethanol, nonalcoholic fatty liver, brain, kidney, stomach, and ovaries in rats. Therefore this study was designed to investigate that how BET influenced iron-related blood parameters and biomarkers in acrylamide-treated rats. Twenty adult rats, weighing 180-200 g and aged 6-7 weeks, were randomly divided into four equal groups and given the following treatments every day for thirty days; the control was G1. The animals in the G2 group were intubated with betaine (250 mg/kg B.W.). The animals in group G3 were intubated with acrylamide (1 mg/kg B.W.) while the animals in group G4 were intubated with betaine plus acrylamide at the same dose as the animals in groups G2, G3. At the end of experiment, theblood samples were obtained using the cardiac puncture technique from anesthetized rats for measuring white blood cells count (WBCs) and their differential count, red blood cells count (RBCs) hemoglobin (Hb) and their related parameter mean corpuscular volume (MCV), mean corpuscular hemoglobin concentration (MCHC), mean corpuscular hemoglobin (MCH), and hematocrit (HCT %), and red cell distribution width (RDW). Besides, serum was taken for measuring serum iron concentration (SI), ferritin and total iron -binding capacity (TIBC),transferrin saturation percentage (T sat%). The results showed significant changesin some hematological parameter and iron status correlated to anemia in group G3 which received acrylamide. Such changes were accompanied with histopathological changes in spleen Oral intubation of betaine alone or concurrently with acrylamide caused alleviation of anemia through correction of previous parameters. On conclusion, the results showed that betaine has a beneficial influence on anemia created in rats given acrylamide. | ||
| کلیدواژه‌ها | ||
| Betaine؛ Acrylamide؛ Iron؛ Hb؛ White blood cells | ||
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آمار تعداد مشاهده مقاله: 44 |
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