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Cytotoxic effect of the crude alcoholic extract of Citrullus Colocynthis fruits plant in the human hepatocyte carcinoma (Hep-G2) | ||
| Archives of Razi Institute | ||
| مقالات آماده انتشار، پذیرفته شده، انتشار آنلاین از تاریخ 01 اردیبهشت 1401 | ||
| نوع مقاله: Original Articles | ||
| شناسه دیجیتال (DOI): 10.22092/ari.2022.357807.2104 | ||
| نویسندگان | ||
Liqaa H. Saqban  1؛ Zainab Abdul Alamir Mezher2؛ Intisar Hussain Ali3
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| 1Biology Department, College of Education for Pure Sciences/ University of Kerbala, Kerbala, Iraq. | ||
| 2Biology Department, College of Education for Pure Sciences/ University of Kerbala, Kerbala, Iraq | ||
| 31 Biology Department, College of Education for Pure Sciences/ University of Kerbala, Kerbala, Iraq. | ||
| چکیده | ||
| The Citrullus Colocynthis L is a perennial herbaceous plant belonging to the family Cucurbitaceae. Several pharmacological investigations have done based on the medicinal application of Citrullus colocynthis. The anticancer and antidiabetic activities of Citrullus colocynthis fruit and seeds extracts have been studied. It seems that newly developed anticancer/antitumor drugs have been developed based on the extracted chemicals from Citrullus colocynthis due to the high contents of cucurbitacins. The aim of this research was to identify the toxic effect of the citrullus colocynthis fruits alcohol extract on the growth of human hepatocyte carcinoma (Hep-G2). The results of the chemical (preliminary) examination of the extract showed that the fruits plant contained most of the secondary metabolites, which included Flavonoids, Tannins, Sapiens, Resins, Amino acids, Glycosides, Terpenes, Alkaloids, Flavonoids. The toxicological effect of the crude extract was investigated by using six half dilutions concentrations (20,10,5,2.5,1.25,0.625) (µg/ml) and for three exposure periods (24,48,72) hours using MTT testing. Thetoxic effect of the plant extract appeared for all the six concentrations in the Hep-G2 cell line. The highest concentration of 20 (µg/ml) gave the highest percentage inhibition ratewith a significant difference (P≤0.01 and it reached (93.36 ±1.61) after a period of (72) hours of exposure.While the lowest concentration (0.625) μg/ml was recorded rate of inhibition (23.36 ± 2.34) after 24 hours exposed. From these findings it can be concluded that the citrullus colocynthis plant is one of the most promising medicinal plants with an effective role in the treatment of cancer through its inhibitory effect and fatal toxicity in cancer cells. | ||
| کلیدواژه‌ها | ||
| Citrullus colocynthis؛ Inhibition Rate؛ human hepatocyte carcinoma؛ Cucurbitacin | ||
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آمار تعداد مشاهده مقاله: 35 |
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