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| تعداد نشریات | 280 |
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Effect of sevoflurane and isoflurane on post- anesthesia cognitive dysfunction in normal and type II diabetic rats | ||
| Archives of Razi Institute | ||
| مقالات آماده انتشار، پذیرفته شده، انتشار آنلاین از تاریخ 02 اردیبهشت 1401 | ||
| نوع مقاله: Original Articles | ||
| شناسه دیجیتال (DOI): 10.22092/ari.2022.358340.2202 | ||
| نویسندگان | ||
ABDELKAREEM E  1؛ TAYEE EM2؛ TAHA AM2؛ ABDELELLATIF M S3
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| 1Department of Clinical Pharmacology, Faculty of Medicine, Al-Azhar University, Damietta, Egypt. Email : e_mansour505@yahoo.com | ||
| 22,3 Department of Clinical Pharmacology, Faculty of Medicine, Helwan University, Cairo, Egypt. Email: dr_sayed_1978@yahoo.com , Email: ahmed999taha@yahoo.com | ||
| 34 Department of Educational Sciences, Faculty of Education, Prince Sattam Bin Abdulaziz University - Kingdom of Saudi Arabia, Wadi Dawaser, Email : m.heby@psau.edu.as | ||
| چکیده | ||
| Both animals and human studies have documented cognitive and behavioral impairment after exposure to inhalational anesthetics. Therefore, the current study was designed to demonstrate if the anesthetics isoflurane and sevoflurane can result postoperative cognition dysfunction in normal and diabetic rats. 60 male Wister rats aged 12 weeks were divided into 6 groups (n=10); group C (normal control), group CD (diabetic control) group S (sevoflurane anesthesia) group I (isoflurane anesthesia) group SD (diabetic sevoflurane anesthesia) group ID (diabetic isoflurane anesthesia). Animals were anesthetized by either 2.5% sevoflurane or 1.5 % isoflurane respectively for 2h. 1 week later animals were undergone cognitive tests on (Morris water maze, T maze and open field arena), thereafter animal were sacrificed and hippocampus homogenates were studied for caspase 3 activity by western blot assay. Induction of type II diabetes in CD, SD and ID groups was carried out by feeding on high fat diet for 8 weeks before the start of experimental . During the fourth week Type II diabetes was induced in the experimental group by single IP injection of 30 mg/kg STZ. Control (normal and diabetic) rats showed no change in long-term/reference memory, non- spatial working memory, exploratory activity or caspase 3 expression in hippocampus homogenate. Anesthesia with isoflurane in normoglycemic rats resulted in significant decline in long-term/reference memory, and non-spatial working memory while exploratory activity and caspase 3 expression in hippocampus homogenate showed no change as compared to normal control rats. Both isoflurane and sevoflurane in diabetic rats demonstrated decline in long-term/reference memory, non-spatial working memory, exploratory activity and caspase 3 expression in hippocampus homogenate as compared with normal control rats. Diabetes revealed significant post-anesthesia cognitive dysfunction after anesthesia with sevoflurane or isoflurane in all the studied domains as compared to either normal control or diabetic control. | ||
| کلیدواژه‌ها | ||
| Sevoflurane؛ Isoflurane؛ Cognitive dysfunction؛ Diabetes mellitus | ||
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آمار تعداد مشاهده مقاله: 37 |
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