Sabeeh, Esraa, . K. Thamer, Nadia, A.M. Alsaady, Hussain. (1401). Histopathological study to evaluate the effectof aqueous extract of Portunuspelagicusand mebendazole on hydatid cysts in mice. سامانه مدیریت نشریات علمی, (), -. doi: 10.22092/ari.2022.358490.2231
Esraa Sabeeh; Nadia . K. Thamer; Hussain A.M. Alsaady. "Histopathological study to evaluate the effectof aqueous extract of Portunuspelagicusand mebendazole on hydatid cysts in mice". سامانه مدیریت نشریات علمی, , , 1401, -. doi: 10.22092/ari.2022.358490.2231
Sabeeh, Esraa, . K. Thamer, Nadia, A.M. Alsaady, Hussain. (1401). 'Histopathological study to evaluate the effectof aqueous extract of Portunuspelagicusand mebendazole on hydatid cysts in mice', سامانه مدیریت نشریات علمی, (), pp. -. doi: 10.22092/ari.2022.358490.2231
Sabeeh, Esraa, . K. Thamer, Nadia, A.M. Alsaady, Hussain. Histopathological study to evaluate the effectof aqueous extract of Portunuspelagicusand mebendazole on hydatid cysts in mice. سامانه مدیریت نشریات علمی, 1401; (): -. doi: 10.22092/ari.2022.358490.2231
Histopathological study to evaluate the effectof aqueous extract of Portunuspelagicusand mebendazole on hydatid cysts in mice
1College of Veterinary Medicine, University of Basrah, Iraq.
23 Biology Department, Science College, University of Misan, Iraq. 4 College of Dentistry, University of Misan, Iraq.
چکیده
Hydatid disease is a parasitic infestation by a tapeworm of the genus Echinococcus sp.which has a global distribution. The current study was conducted to evaluate the effectiveness of the crustacean aqueousextract of Portunuspelagicusfor 2 weeks of treatment compared to mebendazole onhydatidcystinlaboratory mice male Balb / C strain.Micewere infected intraperitoneally with 2000 protoscolices. After 12 weeks of infection, each mice was treated with mebendazole (50mg/kg)and the hot aqueous extract of p.pelagicus (8, 16 g/kg).Samples of infected organs (liver, spleen, and lungs) were examined under a microscope to evaluate the morphological and histopathological changes of hydatid cysts and tissues.The study confirmed macroscopically that there were a number of hydatid cysts of different sizes in the liver, spleen, and lungs, splenomegaly, and congestion of the lungs of the positive control group. The histological changes in the organs of the group treated with the crustacean extract, they were represented by the presence ofvacuolation of hepatocytes in the centrilobular area, of the liver,while in the lungs show intensive peri-bronchiolar inflammation, pulmonary vascular congestion, and in the spleen,the deposition of amyloid-like material in the white pulp, extramedullary hematopoiesis,While the histopathological changes in the organs of mice treated with mebendazole,were represented by the presence in the liver mild vacuolation of the centrilobular area while in lungs show mild pulmonary vascular congestion, emphysema, and also in spleen shows normal white pulp, the normal red pulp of mice.It seems that the aqueous extract Portunuspelagicusandmebendazoleare effective in controlling the contamination in the intermediate hosts