Study the effects of Cordiamyxa fruit extract on induced animal model of depression in male rats

Jasib Habeeb, Yasser; Mohammed Selman, Selman; Jeafer Mehrath, Alaa

doi:10.22092/ari.2022.357642.2082

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	Study the effects of Cordiamyxa fruit extract on induced animal model of depression in male rats
Archives of Razi Institute
مقالات آماده انتشار، پذیرفته شده، انتشار آنلاین از تاریخ 26 اردیبهشت 1401
نوع مقاله: Original Articles
شناسه دیجیتال (DOI): 10.22092/ari.2022.357642.2082
نویسندگان
Yasser Jasib Habeeb ¹؛ Selman Mohammed Selman¹؛ Alaa Jeafer Mehrath²
¹Department of Pharmacology, College of Medicine, University of Babylon, Babel, Iraq
²Department of Biochemistry, college of medicine, University of Babylon ,Babel Iraq
چکیده
Depression is one of the most common mental illnesses. Herbal medications such as ginseng, peony have recently gained a lot of interest in the treatment of depression due to their safety, efficacy, and cost-effectiveness. Therefore, this study was aimed to evaluate actions of C. Myxafruit extract on the model of chronic mild stress (CUMS) and antioxidant enzymes system in male rats' brains. Sixty male rats were divided into six groups (n=10). Group1 (control) was neither exposed to CUMS nor received any treatment while group 2 was exposed to CUMS for 24 days with normal saline treatment for 14 days, group 3 was exposed to CUMS for 24 days and received 10 mg/kg fluoxetine daily on day 10 for 14 days, and group 4, 5 and 6 were exposed to CUMS for 24 days and received C.Myxaextract (125, 250 and 500 mg/kg respectively) on day 10 for 14 days. The antidepressant effect of fluoxetine and C. Myxa extract were evaluated by using forced swim test. At the end of the experiments, animals were sacrificed by decapitation, and antioxidant enzyme levels; catalase (CAT) and superoxide dismutase (SOD were determined by enzyme linked immunosorbent assays kits (Elisa) in rats brain tissues. All groups that subject to CUMS show significant rise in duration of immobility on tenth day by comparsion with day zero. Groups treated with cordiamyxa fruit extract gives results on forced swim test comparable with that of fluoxetine group and reversed the increases on duration of immobility. CUMS produces decline in antioxidants enzymes levels and groups treated with extract show significant rise on enzymes levels (SOD and CAT) by comparsion to group 2. According to this recent study c.myxa may have the antidepressant-like action.
کلیدواژه‌ها
Depression؛ cordia myxa؛ superoxide dismutase؛ Catalase؛ antioxidant enzyme system

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Study the effects of Cordiamyxa fruit extract on induced animal model of depression in male rats