- همه نشریات
- نشریات علمی سازمان تحقیقات، آموزش و ترویچ کشاورزی
- مجلات ترویجی سازمان تحقیقات، آموزش و ترویج کشاورزی
- سایر نشریات سازمان تحقیقات، آموزش و ترویج کشاورزی
- نشریات علمی انجمن ها
- علوم آب و خاک
- علوم اقتصاد و ترویج کشاورزی
- علوم جنگل, مرتع و آبخیزداری
- علوم دامی و شیلات
- علوم زراعی و باغی
- علوم گیاهپزشکی
- علوم مهندسی و مکانیزاسیون کشاورزی
- نشریات با زبان انگلیسی
- نشریات با زبان فارسی
- نشریات دانشگاه آزاد اسلامی
- نشریات علمی
آمار
| تعداد نشریات | 280 |
| تعداد نشریات سازمان | 79 |
| تعداد شماره‌ها | 2,343 |
| تعداد مقالات | 27,131 |
| تعداد مشاهده مقاله | 14,936,451 |
| تعداد دریافت فایل اصل مقاله | 11,934,348 |
Plants Today Drugs Tomorrow: Cordia Grandicalyx A Possible Future Anti-Hypoglycaemic? | ||
| Journal of Medicinal plants and By-product | ||
| مقالات آماده انتشار، پذیرفته شده، انتشار آنلاین از تاریخ 26 اردیبهشت 1401 اصل مقاله (1.42 MB) | ||
| نوع مقاله: Research Paper | ||
| شناسه دیجیتال (DOI): 10.22092/jmpb.2022.356394.1415 | ||
| نویسندگان | ||
Alinah Mildred Chauke   1؛ Leshweni Jeremiah Shai 1؛ Motatelo Alfred Mogale2
| ||
| 1Department of Biomedical Sciences, Tshwane University of Technology, Private Bag X680, Pretoria, South Africa | ||
| 2Department of Biochemistry, Sefako Makgatho Health Science University, Medunsa, South Africa | ||
| چکیده | ||
| Lowering blood glucose levels by enhancing glucose uptake and GLUT4 translocation is an important strategy in glucose homeostasis in insulin-sensitive tissues. Similarly, traditional medicinal plants are used by several traditional healers, and plants are a possible avenue for the discovery and development of antidiabetic drugs. The study aimed to investigate the effects of Cordia grandicalyx bark, fruit, and leaf extracts through glucose uptake activity by preadipocytes, liver and skeletal muscle cells, relative to their capability on increasing GLUT4 translocation. In addition, the protein expression and phosphorylation of diabetes-related proteins were performed. The C. grandicalyx extracts increased glucose uptake activity by enhancing GLUT4 translocation. Moreover, it was established that the co-usage of insulin with plant extracts increased the glucose uptake activity in comparison to insulin. The extracts upregulated total insulin receptor substrate expression and increased the phosphorylation of Akt levels. This data, therefore, suggests that C. grandicalyx enhances glucose uptake by modulating insulin signalling, potentially through GLUT4 translocation and upregulation of diabetes-related proteins, possibly mimicking the PI3-K/Akt pathway. This, therefore, suggests that C. grandicalyx is a possible candidate for the management of diabetes. | ||
| کلیدواژه‌ها | ||
| Medicinal plants؛ Diabetes mellitus؛ Insulin signals؛ C. grandicalyx | ||
|
آمار تعداد مشاهده مقاله: 15 تعداد دریافت فایل اصل مقاله: 10 |
||
